Reviewed, UniProtKB/Swiss-Prot Q2IEX2 (NTPA_ANADE)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

Adeh_3360

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 235	235	Nucleoside-triphosphatase HAMAP MF_01405		PRO_1000068407

Sequences

	Sequence		Length	Mass (Da)
	Q2IEX2-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: BDF0A6FB224A2B89	FASTA	235	24,465
	10 20 30 40 50 60 MDLLFGSTNP GKLRELRRLV AGLPLRVVSP DDLGRPLPVV VEDGATFQAN AEKKAVAWAR 70 80 90 100 110 120 WSGLHAVADD SGLCVDALGG APGVHSARWS DLEPEGPASP VCELAGVAEL ELGPVAGRAA 130 140 150 160 170 180 RDERNNDKLL AALSGLPDPR RGARYEAVLA LARPDGTLVG TVTGTCPGRI GHARRGDGGF 190 200 210 220 230 GYDPLFVPAA ELAAGEGARV RTMAELSSDE KDALSHRGEA FRKLLPMLAA LARGA

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000251 Genomic DNA. Translation: ABC83127.1.
RefSeq	YP_466564.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3889350.
GenomeReviews	Gene locus Adeh_3360 in contig CP000251_GR.
KEGG	ade:Adeh_3360.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2IEX2.
OMA	Q2IEX2. NACLKAS.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_3360-MON.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p-like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTPA_ANADE

Accession

Primary (citable) accession number: Q2IEX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)