Reviewed, UniProtKB/Swiss-Prot Q2IE39 (G6PI_ANADE)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase
      Short name=GPI
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase
      Short name=PGI
    Phosphohexose isomerase
      Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	Adeh_3080

Organism

Anaeromyxobacter dehalogenans (strain 2CP-C) [Complete proteome] [HAMAP]

Taxonomic identifier

290397 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	550 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 550	550	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000252607
Sites
	Active site	357	1	Proton donor By similarity
	Active site	389	1	By similarity
	Active site	509	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2IE39-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 03D0A07868C37B35	FASTA	550	59,816
	10 20 30 40 50 60 MADRNDPLLR TPAWRALETH LAEVRPLHLR ELFARDPGRG DRLAAEGAGL YLDYSKQRVT 70 80 90 100 110 120 EETVRLLVAL AEARGLPGRR AAMFRGEKVN ATEGRAALHV ALRAPRGERI EVDGKDVVPE 130 140 150 160 170 180 VHAVLDRMAA FAEQVRSGAW TGFTGRRIRT VVNVGIGGSD LGPAMAYRAL RAYTTREIAF 190 200 210 220 230 240 RFVSNVDGTD LAEAVRDLDP AETLFLVASK TFTTLETMTN AASARAWLLA ALGDERAVAR 250 260 270 280 290 300 HFVAISTNEA EVRRFGIDPA NMFGFWDWVG GRYSMDSAIG LSTMIAVGPG GFRELLAGFR 310 320 330 340 350 360 AMDEHFRDAP LERNLPALVG LIGVWNASLL GAETVAVLPY DQYLDRFPAY LQQLTMESNG 370 380 390 400 410 420 KRVTASGAPV EGHGTGAIYW GEPGTNGQHS FYQLLHQGTH LVACDFIGFC RTLNPLGRHH 430 440 450 460 470 480 DLLMANLFAQ GEALAFGKTA EEARAEGTPE ALVPHRTFPG NRPSSTILAD RLGPGTLGAL 490 500 510 520 530 540 VALYEHAVFT QGVIWDVDSF DQWGVELGKV LANRIVKELE APADPALAHD GSTNALIRRY 550 RARRGGSASS

References

[1]

"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000251 Genomic DNA. Translation: ABC82849.1.
RefSeq	YP_466286.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3889158.
GenomeReviews	Gene locus Adeh_3080 in contig CP000251_GR.
KEGG	ade:Adeh_3080.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2IE39.
OMA	Q2IE39. PYSNDLA.
Enzyme and pathway databases
BioCyc	ADEH290397:ADEH_3080-MON.
Family and domain databases
HAMAP	MF_00473. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_ANADE

Accession

Primary (citable) accession number: Q2IE39

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)