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Q2IBD4

- CTTB2_RAT

UniProt

Q2IBD4 - CTTB2_RAT

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Protein

Cortactin-binding protein 2

Gene
Cttnbp2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance.1 Publication

GO - Molecular functioni

  1. SH3 domain binding Source: RGD

GO - Biological processi

  1. brain development Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cortactin-binding protein 2
Short name:
CortBP2
Gene namesi
Name:Cttnbp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi628691. Cttnbp2.

Subcellular locationi

Cytoplasmcell cortex By similarity. Cell projectiondendritic spine
Note: Remains associated with dendritic spines even after glutamate stimulation.1 Publication

GO - Cellular componenti

  1. cell cortex Source: UniProtKB-SubCell
  2. dendritic spine Source: UniProtKB-SubCell
  3. synaptic vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16491649Cortactin-binding protein 2PRO_0000422173Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1510 – 15101Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ2IBD4.

Expressioni

Gene expression databases

GenevestigatoriQ2IBD4.

Interactioni

Subunit structurei

Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.2 Publications

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011135.

Structurei

3D structure databases

ProteinModelPortaliQ2IBD4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati699 – 72931ANK 1Add
BLAST
Repeati733 – 76230ANK 2Add
BLAST
Repeati766 – 79530ANK 3Add
BLAST
Repeati799 – 82830ANK 4Add
BLAST
Repeati832 – 86130ANK 5Add
BLAST
Repeati901 – 93131ANK 6Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili118 – 275158 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 6 ANK repeats.

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

GeneTreeiENSGT00680000099614.
HOGENOMiHOG000112055.
HOVERGENiHBG073485.
InParanoidiQ2IBD4.
OMAiSQALTNH.
OrthoDBiEOG77M8NN.
PhylomeDBiQ2IBD4.
TreeFamiTF325130.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR019131. Cortactin-binding_p2_N.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 1 hit.
PF09727. CortBP2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q2IBD4-1) [UniParc]FASTAAdd to Basket

Also known as: CTTNBP2-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATDSASCEP DLSRAPGDAE GATAEAAKKE FDVDTLSKSE LRMLLSVMEG     50
ELEARDLVIE ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGAGDKEK 100
PVCTNPLSIL EAVMAHCRKM QERMSAQLAA AESRQKKLEM EKLQLQALEQ 150
EHKKLAAHLE EERGKNKHVV LMLVKECKQL SGKVVEEAQK LEEVMVKLEE 200
EKKKTSELED QLSAEKQRSA GMEAQLEKQL FEFDTEREQL RAKLTREEAH 250
TTDLKEEIDK MKKMMEQMKK GNDGKPGLSL PRKTKDKRLA SISVATEGPV 300
TRSVACQTDV VTESTDPVKK LPLSVPIKPS TGSPLVSTNT KGNVGPSALL 350
IRPGIDRQAS HSDLGPSPPT ALPSSASRIE ENGPSAGNAP DLSNSTPSTP 400
SGTAPAAAQT LGAAPQNHSQ APPVHSLHSP CANTHPGLNP RIQAARFRFQ 450
GNANDPDQNG NNTQSPPSRD VSPTSRDNLV AKQLARNTVT QALSRFTSPQ 500
AGASSRLGAS PGGDAGTCPP VGRTGLKTPG AARVDRGNPP PIPPKKPGLS 550
QTPSPPHPQL RASNAGAKVD NKIVASPPST LPQGTKVVNE ENVPKSSSPQ 600
LPPKPSIDLT VASAGCPVSA LATSQVGAWP AETPGLNQPA CTDSSLVIPT 650
TVAFRSSINP VSASSRSPGA SDSLLVTASG WSPSLTPLLM SGGPAPLAGR 700
PTLLQQAAAQ GNVTLLSMLL NEEGLDINYC CEDSHSALYS AAKNGHTDCV 750
RLLLNAEARV DAADKNGFTP LCVAAAQGHF ECIELLTAYN ANINHSAAGG 800
QTPLYLACKT GNKECIKLLL EAGTDRSIKT RDGWTPIHAA VDTGNVDSLK 850
LLMYHRVPAP GNSLSAEEPK SGLFSLNGGE SPPGSSKPVV PADLINHADK 900
EGWTAAHIAA SKGFKNCLEI LCRHGGLEPE RRDKCNRTVH DVATDDCKHL 950
LENLNALKIP LRISVGEIQP SNDGSDDFEC EHTICTLNIR KQTSWEDFSK 1000
AVSQALTNHF QAISSDGCWG LEDGTLNNTT DSCIGLGTSS IQSIMLGSIP 1050
WSTGQSFSQS PWDFMKKKKV EQVTVLLSGP QEGCLSSVTY TSMIPLQMLQ 1100
NYLRLVEQYH NVIFHGPEGS LQDYIANQLA LCMKHRQMAA GFPCEIVRAE 1150
VDSGFSKEQL VDVFISNACL IPVKQFPVKK KIIVILENLE KSSLSELLGD 1200
FLAPLENRST ESPCTFQKGN GTSECYYFHE NCFLLGTLAK ACLQGSDLLV 1250
QQHFRWVQLR WDCEPSQGLL QRFLRRKAVS KFRGQLPAPC DPVCKIVDWV 1300
ISVWRQLNSC LARLGTPEAL LGPKYFLSCP VVPGHAQATV KWMSKLWNAI 1350
IAPRVQEAIL SRAAMNKQPG ARQTASKKHP SQGQQAVVRA ALSILLNKAI 1400
LHGCPLPRTE LDQQIADFKG GSFPLSIVSS YSKKKGESAA WRKVNTSPRK 1450
KPGHFSSPMW NKPDLKHEGM RNKSVPHLNI NRSSSLSKQQ SLENDLSMTL 1500
TLDHRLSLGS DDEADLVKEL QSMCSSKSES DISKIADSRE DLRTFDSSRT 1550
NPVTSAPVNL RMPVPQKEAS PLSSHQTTEC SNSKSKTELG VSRVKSFLPV 1600
PRSKVAQCSQ NTKRSSSSSS NTRQLEINNN SKEENWNVDK HEHVEKRNK 1649
Length:1,649
Mass (Da):178,768
Last modified:March 7, 2006 - v1
Checksum:i12C85BF86EB2634B
GO
Isoform 2 (identifier: Q2IBD4-2) [UniParc]FASTAAdd to Basket

Also known as: CTTNBP2-S

The sequence of this isoform differs from the canonical sequence as follows:
     626-630: VGAWP → AGHPP
     631-1649: Missing.

Show »
Length:630
Mass (Da):67,351
Checksum:iCE583C3D3DCBEE8E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei626 – 6305VGAWP → AGHPP in isoform 2. VSP_046479
Alternative sequencei631 – 16491019Missing in isoform 2. VSP_046480Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti163 – 1631R → K in AAC35911. 1 Publication
Sequence conflicti260 – 2601K → Q in AAC35911. 1 Publication
Sequence conflicti280 – 2801L → F in AAC35911. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053768 mRNA. Translation: AAC35911.1.
DP000027 Genomic DNA. Translation: AAR16316.1.
AC087251 Genomic DNA. No translation available.
AC111378 Genomic DNA. No translation available.
AC119088 Genomic DNA. No translation available.
CH473959 Genomic DNA. Translation: EDM15128.1.
RefSeqiNP_001107873.1. NM_001114401.1. [Q2IBD4-1]
UniGeneiRn.16244.

Genome annotation databases

EnsembliENSRNOT00000011135; ENSRNOP00000011135; ENSRNOG00000008440. [Q2IBD4-1]
GeneIDi282587.
KEGGirno:282587.
UCSCiRGD:628691. rat. [Q2IBD4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053768 mRNA. Translation: AAC35911.1 .
DP000027 Genomic DNA. Translation: AAR16316.1 .
AC087251 Genomic DNA. No translation available.
AC111378 Genomic DNA. No translation available.
AC119088 Genomic DNA. No translation available.
CH473959 Genomic DNA. Translation: EDM15128.1 .
RefSeqi NP_001107873.1. NM_001114401.1. [Q2IBD4-1 ]
UniGenei Rn.16244.

3D structure databases

ProteinModelPortali Q2IBD4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000011135.

Proteomic databases

PRIDEi Q2IBD4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011135 ; ENSRNOP00000011135 ; ENSRNOG00000008440 . [Q2IBD4-1 ]
GeneIDi 282587.
KEGGi rno:282587.
UCSCi RGD:628691. rat. [Q2IBD4-1 ]

Organism-specific databases

CTDi 83992.
RGDi 628691. Cttnbp2.

Phylogenomic databases

GeneTreei ENSGT00680000099614.
HOGENOMi HOG000112055.
HOVERGENi HBG073485.
InParanoidi Q2IBD4.
OMAi SQALTNH.
OrthoDBi EOG77M8NN.
PhylomeDBi Q2IBD4.
TreeFami TF325130.

Miscellaneous databases

NextBioi 624821.
PROi Q2IBD4.

Gene expression databases

Genevestigatori Q2IBD4.

Family and domain databases

Gene3Di 1.25.40.20. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR019131. Cortactin-binding_p2_N.
[Graphical view ]
Pfami PF00023. Ank. 2 hits.
PF12796. Ank_2. 1 hit.
PF09727. CortBP2. 2 hits.
[Graphical view ]
SMARTi SM00248. ANK. 6 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 2 hits.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90."
    Ohoka Y., Takai Y.
    Genes Cells 3:603-612(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Comparative analyses of multi-species sequences from targeted genomic regions."
    Thomas J.W., Touchman J.W., Blakesley R.W., Bouffard G.G., Beckstrom-Sternberg S.M., Margulies E.H., Blanchette M., Siepel A.C., Thomas P.J., McDowell J.C., Maskeri B., Hansen N.F., Schwartz M.S., Weber R.J., Kent W.J., Karolchik D., Bruen T.C., Bevan R.
    , Cutler D.J., Schwartz S., Elnitski L., Idol J.R., Prasad A.B., Lee-Lin S.-Q., Maduro V.V.B., Summers T.J., Portnoy M.E., Dietrich N.L., Akhter N., Ayele K., Benjamin B., Cariaga K., Brinkley C.P., Brooks S.Y., Granite S., Guan X., Gupta J., Haghighi P., Ho S.-L., Huang M.C., Karlins E., Laric P.L., Legaspi R., Lim M.J., Maduro Q.L., Masiello C.A., Mastrian S.D., McCloskey J.C., Pearson R., Stantripop S., Tiongson E.E., Tran J.T., Tsurgeon C., Vogt J.L., Walker M.A., Wetherby K.D., Wiggins L.S., Young A.C., Zhang L.-H., Osoegawa K., Zhu B., Zhao B., Shu C.L., De Jong P.J., Lawrence C.E., Smit A.F., Chakravarti A., Haussler D., Green P., Miller W., Green E.D.
    Nature 424:788-793(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance."
    Chen Y.K., Hsueh Y.P.
    J. Neurosci. 32:1043-1055(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CTTN, SUBCELLULAR LOCATION.
  6. "CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex."
    Chen Y.K., Chen C.Y., Hu H.T., Hsueh Y.P.
    Mol. Biol. Cell 23:4383-4392(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STRN; STRN4 AND MOB4.

Entry informationi

Entry nameiCTTB2_RAT
AccessioniPrimary (citable) accession number: Q2IBD4
Secondary accession number(s): O88864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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