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Q2IBD4

- CTTB2_RAT

UniProt

Q2IBD4 - CTTB2_RAT

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Protein

Cortactin-binding protein 2

Gene

Cttnbp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance.1 Publication

GO - Molecular functioni

  1. SH3 domain binding Source: RGD

GO - Biological processi

  1. brain development Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cortactin-binding protein 2
Short name:
CortBP2
Gene namesi
Name:Cttnbp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi628691. Cttnbp2.

Subcellular locationi

Cytoplasmcell cortex By similarity. Cell projectiondendritic spine 1 Publication
Note: Remains associated with dendritic spines even after glutamate stimulation.

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. synaptic vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16491649Cortactin-binding protein 2PRO_0000422173Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1510 – 15101PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ2IBD4.

Expressioni

Gene expression databases

GenevestigatoriQ2IBD4.

Interactioni

Subunit structurei

Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.2 Publications

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011135.

Structurei

3D structure databases

ProteinModelPortaliQ2IBD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati699 – 72931ANK 1Add
BLAST
Repeati733 – 76230ANK 2Add
BLAST
Repeati766 – 79530ANK 3Add
BLAST
Repeati799 – 82830ANK 4Add
BLAST
Repeati832 – 86130ANK 5Add
BLAST
Repeati901 – 93131ANK 6Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili118 – 275158Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

GeneTreeiENSGT00680000099614.
HOGENOMiHOG000112055.
HOVERGENiHBG073485.
InParanoidiQ2IBD4.
OMAiSQALTNH.
OrthoDBiEOG77M8NN.
PhylomeDBiQ2IBD4.
TreeFamiTF325130.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR019131. Cortactin-binding_p2_N.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 1 hit.
PF09727. CortBP2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q2IBD4-1) [UniParc]FASTAAdd to Basket

Also known as: CTTNBP2-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATDSASCEP DLSRAPGDAE GATAEAAKKE FDVDTLSKSE LRMLLSVMEG
60 70 80 90 100
ELEARDLVIE ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGAGDKEK
110 120 130 140 150
PVCTNPLSIL EAVMAHCRKM QERMSAQLAA AESRQKKLEM EKLQLQALEQ
160 170 180 190 200
EHKKLAAHLE EERGKNKHVV LMLVKECKQL SGKVVEEAQK LEEVMVKLEE
210 220 230 240 250
EKKKTSELED QLSAEKQRSA GMEAQLEKQL FEFDTEREQL RAKLTREEAH
260 270 280 290 300
TTDLKEEIDK MKKMMEQMKK GNDGKPGLSL PRKTKDKRLA SISVATEGPV
310 320 330 340 350
TRSVACQTDV VTESTDPVKK LPLSVPIKPS TGSPLVSTNT KGNVGPSALL
360 370 380 390 400
IRPGIDRQAS HSDLGPSPPT ALPSSASRIE ENGPSAGNAP DLSNSTPSTP
410 420 430 440 450
SGTAPAAAQT LGAAPQNHSQ APPVHSLHSP CANTHPGLNP RIQAARFRFQ
460 470 480 490 500
GNANDPDQNG NNTQSPPSRD VSPTSRDNLV AKQLARNTVT QALSRFTSPQ
510 520 530 540 550
AGASSRLGAS PGGDAGTCPP VGRTGLKTPG AARVDRGNPP PIPPKKPGLS
560 570 580 590 600
QTPSPPHPQL RASNAGAKVD NKIVASPPST LPQGTKVVNE ENVPKSSSPQ
610 620 630 640 650
LPPKPSIDLT VASAGCPVSA LATSQVGAWP AETPGLNQPA CTDSSLVIPT
660 670 680 690 700
TVAFRSSINP VSASSRSPGA SDSLLVTASG WSPSLTPLLM SGGPAPLAGR
710 720 730 740 750
PTLLQQAAAQ GNVTLLSMLL NEEGLDINYC CEDSHSALYS AAKNGHTDCV
760 770 780 790 800
RLLLNAEARV DAADKNGFTP LCVAAAQGHF ECIELLTAYN ANINHSAAGG
810 820 830 840 850
QTPLYLACKT GNKECIKLLL EAGTDRSIKT RDGWTPIHAA VDTGNVDSLK
860 870 880 890 900
LLMYHRVPAP GNSLSAEEPK SGLFSLNGGE SPPGSSKPVV PADLINHADK
910 920 930 940 950
EGWTAAHIAA SKGFKNCLEI LCRHGGLEPE RRDKCNRTVH DVATDDCKHL
960 970 980 990 1000
LENLNALKIP LRISVGEIQP SNDGSDDFEC EHTICTLNIR KQTSWEDFSK
1010 1020 1030 1040 1050
AVSQALTNHF QAISSDGCWG LEDGTLNNTT DSCIGLGTSS IQSIMLGSIP
1060 1070 1080 1090 1100
WSTGQSFSQS PWDFMKKKKV EQVTVLLSGP QEGCLSSVTY TSMIPLQMLQ
1110 1120 1130 1140 1150
NYLRLVEQYH NVIFHGPEGS LQDYIANQLA LCMKHRQMAA GFPCEIVRAE
1160 1170 1180 1190 1200
VDSGFSKEQL VDVFISNACL IPVKQFPVKK KIIVILENLE KSSLSELLGD
1210 1220 1230 1240 1250
FLAPLENRST ESPCTFQKGN GTSECYYFHE NCFLLGTLAK ACLQGSDLLV
1260 1270 1280 1290 1300
QQHFRWVQLR WDCEPSQGLL QRFLRRKAVS KFRGQLPAPC DPVCKIVDWV
1310 1320 1330 1340 1350
ISVWRQLNSC LARLGTPEAL LGPKYFLSCP VVPGHAQATV KWMSKLWNAI
1360 1370 1380 1390 1400
IAPRVQEAIL SRAAMNKQPG ARQTASKKHP SQGQQAVVRA ALSILLNKAI
1410 1420 1430 1440 1450
LHGCPLPRTE LDQQIADFKG GSFPLSIVSS YSKKKGESAA WRKVNTSPRK
1460 1470 1480 1490 1500
KPGHFSSPMW NKPDLKHEGM RNKSVPHLNI NRSSSLSKQQ SLENDLSMTL
1510 1520 1530 1540 1550
TLDHRLSLGS DDEADLVKEL QSMCSSKSES DISKIADSRE DLRTFDSSRT
1560 1570 1580 1590 1600
NPVTSAPVNL RMPVPQKEAS PLSSHQTTEC SNSKSKTELG VSRVKSFLPV
1610 1620 1630 1640
PRSKVAQCSQ NTKRSSSSSS NTRQLEINNN SKEENWNVDK HEHVEKRNK
Length:1,649
Mass (Da):178,768
Last modified:March 7, 2006 - v1
Checksum:i12C85BF86EB2634B
GO
Isoform 2 (identifier: Q2IBD4-2) [UniParc]FASTAAdd to Basket

Also known as: CTTNBP2-S

The sequence of this isoform differs from the canonical sequence as follows:
     626-630: VGAWP → AGHPP
     631-1649: Missing.

Show »
Length:630
Mass (Da):67,351
Checksum:iCE583C3D3DCBEE8E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti163 – 1631R → K in AAC35911. (PubMed:9813110)Curated
Sequence conflicti260 – 2601K → Q in AAC35911. (PubMed:9813110)Curated
Sequence conflicti280 – 2801L → F in AAC35911. (PubMed:9813110)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei626 – 6305VGAWP → AGHPP in isoform 2. 1 PublicationVSP_046479
Alternative sequencei631 – 16491019Missing in isoform 2. 1 PublicationVSP_046480Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053768 mRNA. Translation: AAC35911.1.
DP000027 Genomic DNA. Translation: AAR16316.1.
AC087251 Genomic DNA. No translation available.
AC111378 Genomic DNA. No translation available.
AC119088 Genomic DNA. No translation available.
CH473959 Genomic DNA. Translation: EDM15128.1.
RefSeqiNP_001107873.1. NM_001114401.1. [Q2IBD4-1]
UniGeneiRn.16244.

Genome annotation databases

EnsembliENSRNOT00000011135; ENSRNOP00000011135; ENSRNOG00000008440. [Q2IBD4-1]
GeneIDi282587.
KEGGirno:282587.
UCSCiRGD:628691. rat. [Q2IBD4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053768 mRNA. Translation: AAC35911.1 .
DP000027 Genomic DNA. Translation: AAR16316.1 .
AC087251 Genomic DNA. No translation available.
AC111378 Genomic DNA. No translation available.
AC119088 Genomic DNA. No translation available.
CH473959 Genomic DNA. Translation: EDM15128.1 .
RefSeqi NP_001107873.1. NM_001114401.1. [Q2IBD4-1 ]
UniGenei Rn.16244.

3D structure databases

ProteinModelPortali Q2IBD4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000011135.

Proteomic databases

PRIDEi Q2IBD4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011135 ; ENSRNOP00000011135 ; ENSRNOG00000008440 . [Q2IBD4-1 ]
GeneIDi 282587.
KEGGi rno:282587.
UCSCi RGD:628691. rat. [Q2IBD4-1 ]

Organism-specific databases

CTDi 83992.
RGDi 628691. Cttnbp2.

Phylogenomic databases

GeneTreei ENSGT00680000099614.
HOGENOMi HOG000112055.
HOVERGENi HBG073485.
InParanoidi Q2IBD4.
OMAi SQALTNH.
OrthoDBi EOG77M8NN.
PhylomeDBi Q2IBD4.
TreeFami TF325130.

Miscellaneous databases

NextBioi 624821.
PROi Q2IBD4.

Gene expression databases

Genevestigatori Q2IBD4.

Family and domain databases

Gene3Di 1.25.40.20. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR019131. Cortactin-binding_p2_N.
[Graphical view ]
Pfami PF00023. Ank. 2 hits.
PF12796. Ank_2. 1 hit.
PF09727. CortBP2. 2 hits.
[Graphical view ]
SMARTi SM00248. ANK. 6 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 2 hits.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90."
    Ohoka Y., Takai Y.
    Genes Cells 3:603-612(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Comparative analyses of multi-species sequences from targeted genomic regions."
    Thomas J.W., Touchman J.W., Blakesley R.W., Bouffard G.G., Beckstrom-Sternberg S.M., Margulies E.H., Blanchette M., Siepel A.C., Thomas P.J., McDowell J.C., Maskeri B., Hansen N.F., Schwartz M.S., Weber R.J., Kent W.J., Karolchik D., Bruen T.C., Bevan R.
    , Cutler D.J., Schwartz S., Elnitski L., Idol J.R., Prasad A.B., Lee-Lin S.-Q., Maduro V.V.B., Summers T.J., Portnoy M.E., Dietrich N.L., Akhter N., Ayele K., Benjamin B., Cariaga K., Brinkley C.P., Brooks S.Y., Granite S., Guan X., Gupta J., Haghighi P., Ho S.-L., Huang M.C., Karlins E., Laric P.L., Legaspi R., Lim M.J., Maduro Q.L., Masiello C.A., Mastrian S.D., McCloskey J.C., Pearson R., Stantripop S., Tiongson E.E., Tran J.T., Tsurgeon C., Vogt J.L., Walker M.A., Wetherby K.D., Wiggins L.S., Young A.C., Zhang L.-H., Osoegawa K., Zhu B., Zhao B., Shu C.L., De Jong P.J., Lawrence C.E., Smit A.F., Chakravarti A., Haussler D., Green P., Miller W., Green E.D.
    Nature 424:788-793(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance."
    Chen Y.K., Hsueh Y.P.
    J. Neurosci. 32:1043-1055(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CTTN, SUBCELLULAR LOCATION.
  6. "CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex."
    Chen Y.K., Chen C.Y., Hu H.T., Hsueh Y.P.
    Mol. Biol. Cell 23:4383-4392(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STRN; STRN4 AND MOB4.

Entry informationi

Entry nameiCTTB2_RAT
AccessioniPrimary (citable) accession number: Q2IBD4
Secondary accession number(s): O88864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3