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Q2IBD4

- CTTB2_RAT

UniProt

Q2IBD4 - CTTB2_RAT

Protein

Cortactin-binding protein 2

Gene

Cttnbp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance.1 Publication

    GO - Molecular functioni

    1. SH3 domain binding Source: RGD

    GO - Biological processi

    1. brain development Source: RGD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cortactin-binding protein 2
    Short name:
    CortBP2
    Gene namesi
    Name:Cttnbp2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi628691. Cttnbp2.

    Subcellular locationi

    Cytoplasmcell cortex By similarity. Cell projectiondendritic spine 1 Publication
    Note: Remains associated with dendritic spines even after glutamate stimulation.

    GO - Cellular componenti

    1. cell cortex Source: UniProtKB-SubCell
    2. dendritic spine Source: UniProtKB-SubCell
    3. synaptic vesicle Source: RGD

    Keywords - Cellular componenti

    Cell projection, Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16491649Cortactin-binding protein 2PRO_0000422173Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1510 – 15101PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ2IBD4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ2IBD4.

    Interactioni

    Subunit structurei

    Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.2 Publications

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000011135.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2IBD4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati699 – 72931ANK 1Add
    BLAST
    Repeati733 – 76230ANK 2Add
    BLAST
    Repeati766 – 79530ANK 3Add
    BLAST
    Repeati799 – 82830ANK 4Add
    BLAST
    Repeati832 – 86130ANK 5Add
    BLAST
    Repeati901 – 93131ANK 6Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili118 – 275158Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 6 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat

    Phylogenomic databases

    GeneTreeiENSGT00680000099614.
    HOGENOMiHOG000112055.
    HOVERGENiHBG073485.
    InParanoidiQ2IBD4.
    OMAiSQALTNH.
    OrthoDBiEOG77M8NN.
    PhylomeDBiQ2IBD4.
    TreeFamiTF325130.

    Family and domain databases

    Gene3Di1.25.40.20. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR019131. Cortactin-binding_p2_N.
    [Graphical view]
    PfamiPF00023. Ank. 2 hits.
    PF12796. Ank_2. 1 hit.
    PF09727. CortBP2. 2 hits.
    [Graphical view]
    SMARTiSM00248. ANK. 6 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 2 hits.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q2IBD4-1) [UniParc]FASTAAdd to Basket

    Also known as: CTTNBP2-L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATDSASCEP DLSRAPGDAE GATAEAAKKE FDVDTLSKSE LRMLLSVMEG     50
    ELEARDLVIE ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGAGDKEK 100
    PVCTNPLSIL EAVMAHCRKM QERMSAQLAA AESRQKKLEM EKLQLQALEQ 150
    EHKKLAAHLE EERGKNKHVV LMLVKECKQL SGKVVEEAQK LEEVMVKLEE 200
    EKKKTSELED QLSAEKQRSA GMEAQLEKQL FEFDTEREQL RAKLTREEAH 250
    TTDLKEEIDK MKKMMEQMKK GNDGKPGLSL PRKTKDKRLA SISVATEGPV 300
    TRSVACQTDV VTESTDPVKK LPLSVPIKPS TGSPLVSTNT KGNVGPSALL 350
    IRPGIDRQAS HSDLGPSPPT ALPSSASRIE ENGPSAGNAP DLSNSTPSTP 400
    SGTAPAAAQT LGAAPQNHSQ APPVHSLHSP CANTHPGLNP RIQAARFRFQ 450
    GNANDPDQNG NNTQSPPSRD VSPTSRDNLV AKQLARNTVT QALSRFTSPQ 500
    AGASSRLGAS PGGDAGTCPP VGRTGLKTPG AARVDRGNPP PIPPKKPGLS 550
    QTPSPPHPQL RASNAGAKVD NKIVASPPST LPQGTKVVNE ENVPKSSSPQ 600
    LPPKPSIDLT VASAGCPVSA LATSQVGAWP AETPGLNQPA CTDSSLVIPT 650
    TVAFRSSINP VSASSRSPGA SDSLLVTASG WSPSLTPLLM SGGPAPLAGR 700
    PTLLQQAAAQ GNVTLLSMLL NEEGLDINYC CEDSHSALYS AAKNGHTDCV 750
    RLLLNAEARV DAADKNGFTP LCVAAAQGHF ECIELLTAYN ANINHSAAGG 800
    QTPLYLACKT GNKECIKLLL EAGTDRSIKT RDGWTPIHAA VDTGNVDSLK 850
    LLMYHRVPAP GNSLSAEEPK SGLFSLNGGE SPPGSSKPVV PADLINHADK 900
    EGWTAAHIAA SKGFKNCLEI LCRHGGLEPE RRDKCNRTVH DVATDDCKHL 950
    LENLNALKIP LRISVGEIQP SNDGSDDFEC EHTICTLNIR KQTSWEDFSK 1000
    AVSQALTNHF QAISSDGCWG LEDGTLNNTT DSCIGLGTSS IQSIMLGSIP 1050
    WSTGQSFSQS PWDFMKKKKV EQVTVLLSGP QEGCLSSVTY TSMIPLQMLQ 1100
    NYLRLVEQYH NVIFHGPEGS LQDYIANQLA LCMKHRQMAA GFPCEIVRAE 1150
    VDSGFSKEQL VDVFISNACL IPVKQFPVKK KIIVILENLE KSSLSELLGD 1200
    FLAPLENRST ESPCTFQKGN GTSECYYFHE NCFLLGTLAK ACLQGSDLLV 1250
    QQHFRWVQLR WDCEPSQGLL QRFLRRKAVS KFRGQLPAPC DPVCKIVDWV 1300
    ISVWRQLNSC LARLGTPEAL LGPKYFLSCP VVPGHAQATV KWMSKLWNAI 1350
    IAPRVQEAIL SRAAMNKQPG ARQTASKKHP SQGQQAVVRA ALSILLNKAI 1400
    LHGCPLPRTE LDQQIADFKG GSFPLSIVSS YSKKKGESAA WRKVNTSPRK 1450
    KPGHFSSPMW NKPDLKHEGM RNKSVPHLNI NRSSSLSKQQ SLENDLSMTL 1500
    TLDHRLSLGS DDEADLVKEL QSMCSSKSES DISKIADSRE DLRTFDSSRT 1550
    NPVTSAPVNL RMPVPQKEAS PLSSHQTTEC SNSKSKTELG VSRVKSFLPV 1600
    PRSKVAQCSQ NTKRSSSSSS NTRQLEINNN SKEENWNVDK HEHVEKRNK 1649
    Length:1,649
    Mass (Da):178,768
    Last modified:March 7, 2006 - v1
    Checksum:i12C85BF86EB2634B
    GO
    Isoform 2 (identifier: Q2IBD4-2) [UniParc]FASTAAdd to Basket

    Also known as: CTTNBP2-S

    The sequence of this isoform differs from the canonical sequence as follows:
         626-630: VGAWP → AGHPP
         631-1649: Missing.

    Show »
    Length:630
    Mass (Da):67,351
    Checksum:iCE583C3D3DCBEE8E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti163 – 1631R → K in AAC35911. (PubMed:9813110)Curated
    Sequence conflicti260 – 2601K → Q in AAC35911. (PubMed:9813110)Curated
    Sequence conflicti280 – 2801L → F in AAC35911. (PubMed:9813110)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei626 – 6305VGAWP → AGHPP in isoform 2. 1 PublicationVSP_046479
    Alternative sequencei631 – 16491019Missing in isoform 2. 1 PublicationVSP_046480Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053768 mRNA. Translation: AAC35911.1.
    DP000027 Genomic DNA. Translation: AAR16316.1.
    AC087251 Genomic DNA. No translation available.
    AC111378 Genomic DNA. No translation available.
    AC119088 Genomic DNA. No translation available.
    CH473959 Genomic DNA. Translation: EDM15128.1.
    RefSeqiNP_001107873.1. NM_001114401.1. [Q2IBD4-1]
    UniGeneiRn.16244.

    Genome annotation databases

    EnsembliENSRNOT00000011135; ENSRNOP00000011135; ENSRNOG00000008440. [Q2IBD4-1]
    GeneIDi282587.
    KEGGirno:282587.
    UCSCiRGD:628691. rat. [Q2IBD4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053768 mRNA. Translation: AAC35911.1 .
    DP000027 Genomic DNA. Translation: AAR16316.1 .
    AC087251 Genomic DNA. No translation available.
    AC111378 Genomic DNA. No translation available.
    AC119088 Genomic DNA. No translation available.
    CH473959 Genomic DNA. Translation: EDM15128.1 .
    RefSeqi NP_001107873.1. NM_001114401.1. [Q2IBD4-1 ]
    UniGenei Rn.16244.

    3D structure databases

    ProteinModelPortali Q2IBD4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000011135.

    Proteomic databases

    PRIDEi Q2IBD4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011135 ; ENSRNOP00000011135 ; ENSRNOG00000008440 . [Q2IBD4-1 ]
    GeneIDi 282587.
    KEGGi rno:282587.
    UCSCi RGD:628691. rat. [Q2IBD4-1 ]

    Organism-specific databases

    CTDi 83992.
    RGDi 628691. Cttnbp2.

    Phylogenomic databases

    GeneTreei ENSGT00680000099614.
    HOGENOMi HOG000112055.
    HOVERGENi HBG073485.
    InParanoidi Q2IBD4.
    OMAi SQALTNH.
    OrthoDBi EOG77M8NN.
    PhylomeDBi Q2IBD4.
    TreeFami TF325130.

    Miscellaneous databases

    NextBioi 624821.
    PROi Q2IBD4.

    Gene expression databases

    Genevestigatori Q2IBD4.

    Family and domain databases

    Gene3Di 1.25.40.20. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR019131. Cortactin-binding_p2_N.
    [Graphical view ]
    Pfami PF00023. Ank. 2 hits.
    PF12796. Ank_2. 1 hit.
    PF09727. CortBP2. 2 hits.
    [Graphical view ]
    SMARTi SM00248. ANK. 6 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 2 hits.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90."
      Ohoka Y., Takai Y.
      Genes Cells 3:603-612(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Comparative analyses of multi-species sequences from targeted genomic regions."
      Thomas J.W., Touchman J.W., Blakesley R.W., Bouffard G.G., Beckstrom-Sternberg S.M., Margulies E.H., Blanchette M., Siepel A.C., Thomas P.J., McDowell J.C., Maskeri B., Hansen N.F., Schwartz M.S., Weber R.J., Kent W.J., Karolchik D., Bruen T.C., Bevan R.
      , Cutler D.J., Schwartz S., Elnitski L., Idol J.R., Prasad A.B., Lee-Lin S.-Q., Maduro V.V.B., Summers T.J., Portnoy M.E., Dietrich N.L., Akhter N., Ayele K., Benjamin B., Cariaga K., Brinkley C.P., Brooks S.Y., Granite S., Guan X., Gupta J., Haghighi P., Ho S.-L., Huang M.C., Karlins E., Laric P.L., Legaspi R., Lim M.J., Maduro Q.L., Masiello C.A., Mastrian S.D., McCloskey J.C., Pearson R., Stantripop S., Tiongson E.E., Tran J.T., Tsurgeon C., Vogt J.L., Walker M.A., Wetherby K.D., Wiggins L.S., Young A.C., Zhang L.-H., Osoegawa K., Zhu B., Zhao B., Shu C.L., De Jong P.J., Lawrence C.E., Smit A.F., Chakravarti A., Haussler D., Green P., Miller W., Green E.D.
      Nature 424:788-793(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance."
      Chen Y.K., Hsueh Y.P.
      J. Neurosci. 32:1043-1055(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CTTN, SUBCELLULAR LOCATION.
    6. "CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex."
      Chen Y.K., Chen C.Y., Hu H.T., Hsueh Y.P.
      Mol. Biol. Cell 23:4383-4392(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH STRN; STRN4 AND MOB4.

    Entry informationi

    Entry nameiCTTB2_RAT
    AccessioniPrimary (citable) accession number: Q2IBD4
    Secondary accession number(s): O88864
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2013
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3