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Q2IBD4 (CTTB2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cortactin-binding protein 2

Short name=CortBP2
Gene names
Name:Cttnbp2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1649 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance. Ref.5

Subunit structure

Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4. Ref.5 Ref.6

Subcellular location

Cytoplasmcell cortex By similarity. Cell projectiondendritic spine. Note: Remains associated with dendritic spines even after glutamate stimulation. Ref.5

Sequence similarities

Contains 6 ANK repeats.

Ontologies

Keywords
   Cellular componentCell projection
Cytoplasm
   Coding sequence diversityAlternative splicing
   DomainANK repeat
Coiled coil
Repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbrain development

Inferred from expression pattern Ref.1. Source: RGD

   Cellular_componentcell cortex

Inferred from electronic annotation. Source: UniProtKB-SubCell

dendritic spine

Inferred from electronic annotation. Source: UniProtKB-SubCell

synaptic vesicle

Inferred from direct assay Ref.1. Source: RGD

   Molecular_functionSH3 domain binding

Inferred from physical interaction Ref.1. Source: RGD

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q2IBD4-1)

Also known as: CTTNBP2-L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q2IBD4-2)

Also known as: CTTNBP2-S;

The sequence of this isoform differs from the canonical sequence as follows:
     626-630: VGAWP → AGHPP
     631-1649: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16491649Cortactin-binding protein 2
PRO_0000422173

Regions

Repeat699 – 72931ANK 1
Repeat733 – 76230ANK 2
Repeat766 – 79530ANK 3
Repeat799 – 82830ANK 4
Repeat832 – 86130ANK 5
Repeat901 – 93131ANK 6
Coiled coil118 – 275158 Potential

Amino acid modifications

Modified residue15101Phosphoserine By similarity

Natural variations

Alternative sequence626 – 6305VGAWP → AGHPP in isoform 2.
VSP_046479
Alternative sequence631 – 16491019Missing in isoform 2.
VSP_046480

Experimental info

Sequence conflict1631R → K in AAC35911. Ref.1
Sequence conflict2601K → Q in AAC35911. Ref.1
Sequence conflict2801L → F in AAC35911. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (CTTNBP2-L) [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 12C85BF86EB2634B

FASTA1,649178,768
        10         20         30         40         50         60 
MATDSASCEP DLSRAPGDAE GATAEAAKKE FDVDTLSKSE LRMLLSVMEG ELEARDLVIE 

        70         80         90        100        110        120 
ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGAGDKEK PVCTNPLSIL EAVMAHCRKM 

       130        140        150        160        170        180 
QERMSAQLAA AESRQKKLEM EKLQLQALEQ EHKKLAAHLE EERGKNKHVV LMLVKECKQL 

       190        200        210        220        230        240 
SGKVVEEAQK LEEVMVKLEE EKKKTSELED QLSAEKQRSA GMEAQLEKQL FEFDTEREQL 

       250        260        270        280        290        300 
RAKLTREEAH TTDLKEEIDK MKKMMEQMKK GNDGKPGLSL PRKTKDKRLA SISVATEGPV 

       310        320        330        340        350        360 
TRSVACQTDV VTESTDPVKK LPLSVPIKPS TGSPLVSTNT KGNVGPSALL IRPGIDRQAS 

       370        380        390        400        410        420 
HSDLGPSPPT ALPSSASRIE ENGPSAGNAP DLSNSTPSTP SGTAPAAAQT LGAAPQNHSQ 

       430        440        450        460        470        480 
APPVHSLHSP CANTHPGLNP RIQAARFRFQ GNANDPDQNG NNTQSPPSRD VSPTSRDNLV 

       490        500        510        520        530        540 
AKQLARNTVT QALSRFTSPQ AGASSRLGAS PGGDAGTCPP VGRTGLKTPG AARVDRGNPP 

       550        560        570        580        590        600 
PIPPKKPGLS QTPSPPHPQL RASNAGAKVD NKIVASPPST LPQGTKVVNE ENVPKSSSPQ 

       610        620        630        640        650        660 
LPPKPSIDLT VASAGCPVSA LATSQVGAWP AETPGLNQPA CTDSSLVIPT TVAFRSSINP 

       670        680        690        700        710        720 
VSASSRSPGA SDSLLVTASG WSPSLTPLLM SGGPAPLAGR PTLLQQAAAQ GNVTLLSMLL 

       730        740        750        760        770        780 
NEEGLDINYC CEDSHSALYS AAKNGHTDCV RLLLNAEARV DAADKNGFTP LCVAAAQGHF 

       790        800        810        820        830        840 
ECIELLTAYN ANINHSAAGG QTPLYLACKT GNKECIKLLL EAGTDRSIKT RDGWTPIHAA 

       850        860        870        880        890        900 
VDTGNVDSLK LLMYHRVPAP GNSLSAEEPK SGLFSLNGGE SPPGSSKPVV PADLINHADK 

       910        920        930        940        950        960 
EGWTAAHIAA SKGFKNCLEI LCRHGGLEPE RRDKCNRTVH DVATDDCKHL LENLNALKIP 

       970        980        990       1000       1010       1020 
LRISVGEIQP SNDGSDDFEC EHTICTLNIR KQTSWEDFSK AVSQALTNHF QAISSDGCWG 

      1030       1040       1050       1060       1070       1080 
LEDGTLNNTT DSCIGLGTSS IQSIMLGSIP WSTGQSFSQS PWDFMKKKKV EQVTVLLSGP 

      1090       1100       1110       1120       1130       1140 
QEGCLSSVTY TSMIPLQMLQ NYLRLVEQYH NVIFHGPEGS LQDYIANQLA LCMKHRQMAA 

      1150       1160       1170       1180       1190       1200 
GFPCEIVRAE VDSGFSKEQL VDVFISNACL IPVKQFPVKK KIIVILENLE KSSLSELLGD 

      1210       1220       1230       1240       1250       1260 
FLAPLENRST ESPCTFQKGN GTSECYYFHE NCFLLGTLAK ACLQGSDLLV QQHFRWVQLR 

      1270       1280       1290       1300       1310       1320 
WDCEPSQGLL QRFLRRKAVS KFRGQLPAPC DPVCKIVDWV ISVWRQLNSC LARLGTPEAL 

      1330       1340       1350       1360       1370       1380 
LGPKYFLSCP VVPGHAQATV KWMSKLWNAI IAPRVQEAIL SRAAMNKQPG ARQTASKKHP 

      1390       1400       1410       1420       1430       1440 
SQGQQAVVRA ALSILLNKAI LHGCPLPRTE LDQQIADFKG GSFPLSIVSS YSKKKGESAA 

      1450       1460       1470       1480       1490       1500 
WRKVNTSPRK KPGHFSSPMW NKPDLKHEGM RNKSVPHLNI NRSSSLSKQQ SLENDLSMTL 

      1510       1520       1530       1540       1550       1560 
TLDHRLSLGS DDEADLVKEL QSMCSSKSES DISKIADSRE DLRTFDSSRT NPVTSAPVNL 

      1570       1580       1590       1600       1610       1620 
RMPVPQKEAS PLSSHQTTEC SNSKSKTELG VSRVKSFLPV PRSKVAQCSQ NTKRSSSSSS 

      1630       1640 
NTRQLEINNN SKEENWNVDK HEHVEKRNK 

« Hide

Isoform 2 (CTTNBP2-S) [UniParc].

Checksum: CE583C3D3DCBEE8E
Show »

FASTA63067,351

References

« Hide 'large scale' references
[1]"Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90."
Ohoka Y., Takai Y.
Genes Cells 3:603-612(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Comparative analyses of multi-species sequences from targeted genomic regions."
Thomas J.W., Touchman J.W., Blakesley R.W., Bouffard G.G., Beckstrom-Sternberg S.M., Margulies E.H., Blanchette M., Siepel A.C., Thomas P.J., McDowell J.C., Maskeri B., Hansen N.F., Schwartz M.S., Weber R.J., Kent W.J., Karolchik D., Bruen T.C., Bevan R. expand/collapse author list , Cutler D.J., Schwartz S., Elnitski L., Idol J.R., Prasad A.B., Lee-Lin S.-Q., Maduro V.V.B., Summers T.J., Portnoy M.E., Dietrich N.L., Akhter N., Ayele K., Benjamin B., Cariaga K., Brinkley C.P., Brooks S.Y., Granite S., Guan X., Gupta J., Haghighi P., Ho S.-L., Huang M.C., Karlins E., Laric P.L., Legaspi R., Lim M.J., Maduro Q.L., Masiello C.A., Mastrian S.D., McCloskey J.C., Pearson R., Stantripop S., Tiongson E.E., Tran J.T., Tsurgeon C., Vogt J.L., Walker M.A., Wetherby K.D., Wiggins L.S., Young A.C., Zhang L.-H., Osoegawa K., Zhu B., Zhao B., Shu C.L., De Jong P.J., Lawrence C.E., Smit A.F., Chakravarti A., Haussler D., Green P., Miller W., Green E.D.
Nature 424:788-793(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[3]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance."
Chen Y.K., Hsueh Y.P.
J. Neurosci. 32:1043-1055(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CTTN, SUBCELLULAR LOCATION.
[6]"CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex."
Chen Y.K., Chen C.Y., Hu H.T., Hsueh Y.P.
Mol. Biol. Cell 23:4383-4392(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH STRN; STRN4 AND MOB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF053768 mRNA. Translation: AAC35911.1.
DP000027 Genomic DNA. Translation: AAR16316.1.
AC087251 Genomic DNA. No translation available.
AC111378 Genomic DNA. No translation available.
AC119088 Genomic DNA. No translation available.
CH473959 Genomic DNA. Translation: EDM15128.1.
RefSeqNP_001107873.1. NM_001114401.1.
UniGeneRn.16244.

3D structure databases

ProteinModelPortalQ2IBD4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000011135.

Proteomic databases

PRIDEQ2IBD4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000011135; ENSRNOP00000011135; ENSRNOG00000008440. [Q2IBD4-1]
GeneID282587.
KEGGrno:282587.
UCSCRGD:628691. rat. [Q2IBD4-1]

Organism-specific databases

CTD83992.
RGD628691. Cttnbp2.

Phylogenomic databases

GeneTreeENSGT00680000099614.
HOGENOMHOG000112055.
HOVERGENHBG073485.
InParanoidQ2IBD4.
OMASQALTNH.
OrthoDBEOG77M8NN.
PhylomeDBQ2IBD4.
TreeFamTF325130.

Gene expression databases

GenevestigatorQ2IBD4.

Family and domain databases

Gene3D1.25.40.20. 2 hits.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR019131. Cortactin-binding_p2_N.
[Graphical view]
PfamPF00023. Ank. 2 hits.
PF12796. Ank_2. 1 hit.
PF09727. CortBP2. 2 hits.
[Graphical view]
SMARTSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 2 hits.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio624821.
PROQ2IBD4.

Entry information

Entry nameCTTB2_RAT
AccessionPrimary (citable) accession number: Q2IBD4
Secondary accession number(s): O88864
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: March 7, 2006
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families