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Protein

Suppressor of tumorigenicity 7 protein

Gene

St7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of tumorigenicity 7 protein
Gene namesi
Name:St7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1303148. ST7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521HelicalSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Transmembranei512 – 53221HelicalSequence analysisAdd
BLAST
Transmembranei539 – 55921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 577577Suppressor of tumorigenicity 7 proteinPRO_0000339215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence analysis
Modified residuei386 – 3861PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ2IBD0.

PTM databases

PhosphoSiteiQ2IBD0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007474.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010219.

Family & Domainsi

Sequence similaritiesi

Belongs to the ST7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3807. Eukaryota.
ENOG410XQ2Z. LUCA.
GeneTreeiENSGT00390000000873.
HOGENOMiHOG000036528.
HOVERGENiHBG054916.
InParanoidiQ2IBD0.
PhylomeDBiQ2IBD0.
TreeFamiTF314162.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR007311. ST7.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR12745. PTHR12745. 2 hits.
PfamiPF04184. ST7. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2IBD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAGSGFLE QLKSCIVWSW TYLWTVWFFL VLFLVYILRV PLRINDNLST
60 70 80 90 100
VSMFLNTLTP KFYVALTGTS SLISGLILIF EWWYFRKYGT SFIEQVSVSH
110 120 130 140 150
LRPLLGGVDN NSSNNSNSSN GDSDSNRQSV SECKVWRNPL NLFRGAEYNR
160 170 180 190 200
YTWVTGREPL TYYDMNLSAQ DHQTFFTCDS DHLRPADAIM QKAWRERNPQ
210 220 230 240 250
ARISAAHEAL EINEIRSRVE VPLIASSTIW EIKLLPKCAT AYILLAEEEA
260 270 280 290 300
TTIAEAEKLF KQALKAGDGC YRRSQQLQHH GSQYEAQHRR DTNVLVYIKR
310 320 330 340 350
RLAMCARRLG RTREAVKMMR DLMKEFPLLS MFNIHENLLE ALLELQAYAD
360 370 380 390 400
VQAVLAKYDD ISLPKSATIC YTAALLKARA VSDKFSPEAA SRRGLSTAEM
410 420 430 440 450
NAVEAIHRAV EFNPHVPKYL LEMKSLILPP EHILKRGDSE AIAYAFFHLA
460 470 480 490 500
HWKRVEGALN LLHCTWEGTF RMIPYPLEKG HLFYPYPICT ETADRELLPS
510 520 530 540 550
FHEVSVYPKK ELPFFILFTA GLCSFTAMLA LLTHQFPELM GVFAKAFLST
560 570
LFAPLNFVME KVESILPSSL WHQLTRI
Length:577
Mass (Da):66,111
Last modified:March 7, 2006 - v1
Checksum:iE3256054BD796258
GO
Isoform 2 (identifier: Q2IBD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-237: Missing.
     470-500: Missing.

Show »
Length:523
Mass (Da):59,800
Checksum:i68AB5E218E00E759
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61S → A in AAH99820 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei215 – 23723Missing in isoform 2. 1 PublicationVSP_034125Add
BLAST
Alternative sequencei470 – 50031Missing in isoform 2. 1 PublicationVSP_034126Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000027 Genomic DNA. Translation: AAR16311.1.
BC099820 mRNA. Translation: AAH99820.1.
RefSeqiXP_006236194.1. XM_006236132.2. [Q2IBD0-1]
UniGeneiRn.24435.

Genome annotation databases

EnsembliENSRNOT00000084736; ENSRNOP00000071529; ENSRNOG00000056243. [Q2IBD0-2]
GeneIDi296911.
UCSCiRGD:1303148. rat. [Q2IBD0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000027 Genomic DNA. Translation: AAR16311.1.
BC099820 mRNA. Translation: AAH99820.1.
RefSeqiXP_006236194.1. XM_006236132.2. [Q2IBD0-1]
UniGeneiRn.24435.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010219.

PTM databases

PhosphoSiteiQ2IBD0.

Proteomic databases

PaxDbiQ2IBD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000084736; ENSRNOP00000071529; ENSRNOG00000056243. [Q2IBD0-2]
GeneIDi296911.
UCSCiRGD:1303148. rat. [Q2IBD0-1]

Organism-specific databases

CTDi7982.
RGDi1303148. ST7.

Phylogenomic databases

eggNOGiKOG3807. Eukaryota.
ENOG410XQ2Z. LUCA.
GeneTreeiENSGT00390000000873.
HOGENOMiHOG000036528.
HOVERGENiHBG054916.
InParanoidiQ2IBD0.
PhylomeDBiQ2IBD0.
TreeFamiTF314162.

Miscellaneous databases

PROiQ2IBD0.

Gene expression databases

BgeeiENSRNOG00000007474.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR007311. ST7.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR12745. PTHR12745. 2 hits.
PfamiPF04184. ST7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiST7_RAT
AccessioniPrimary (citable) accession number: Q2IBD0
Secondary accession number(s): Q499P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.