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Protein
Submitted name:

Extracellular hemoglobin linker L3 subunit

Gene
N/A
Organism
Lumbricus terrestris (Common earthworm)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Extracellular hemoglobin linker L3 subunitImported
OrganismiLumbricus terrestris (Common earthworm)Imported
Taxonomic identifieri6398 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataOligochaetaHaplotaxidaLumbricinaLumbricidaeLumbricinaeLumbricus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 240220Sequence analysisPRO_5004209990Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi80 ↔ 94Combined sources
Disulfide bondi87 ↔ 107Combined sources
Disulfide bondi101 ↔ 116Combined sources
Disulfide bondi135 ↔ 231Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

DIPiDIP-29128N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GTLX-ray3.50O26-240[»]
4V93electron microscopy8.10C2/C7/CE/CJ/CO/CT/CY/Cd/Ci/Cn/Cs/Cx1-240[»]
ProteinModelPortaliQ2I742.
SMRiQ2I742. Positions 26-240.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ2I742.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini119 – 239121Eryth_link_CInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di4.10.400.10. 1 hit.
InterProiIPR031639. Eryth_link_C.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF16915. Eryth_link_C. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
[Graphical view]
SMARTiSM00192. LDLa. 1 hit.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
PROSITEiPS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2I742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLGLLLAA LAVVVTLASA DSPPAQSHDE IIDKLIERTN KITTSISHVE
60 70 80 90 100
SLLDDRLDPK RIRKAGSLRH RVEELEDPSC DEHEHQCGGD DPQCISKLFV
110 120 130 140 150
CDGHNDCRNG EDEKDCTLPT KAGDKFIGDV VFDHCTKRRP EHMTLAFESS
160 170 180 190 200
SIAAFFTPIA DLHVHIEIES ETDEDESEVS MPADGEYSFA DHRLTIHPPE
210 220 230 240
EDGLGLVGEF DGYNFDRFVG HIVHELSEEV CAEFIFHRKK
Length:240
Mass (Da):26,835
Last modified:March 7, 2006 - v1
Checksum:iA40EE0F41C57EC98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ234598 mRNA. Translation: ABB71123.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ234598 mRNA. Translation: ABB71123.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GTLX-ray3.50O26-240[»]
4V93electron microscopy8.10C2/C7/CE/CJ/CO/CT/CY/Cd/Ci/Cn/Cs/Cx1-240[»]
ProteinModelPortaliQ2I742.
SMRiQ2I742. Positions 26-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29128N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ2I742.

Family and domain databases

Gene3Di4.10.400.10. 1 hit.
InterProiIPR031639. Eryth_link_C.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF16915. Eryth_link_C. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
[Graphical view]
SMARTiSM00192. LDLa. 1 hit.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
PROSITEiPS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Linker Chains of the Gigantic Hemoglobin of the Earthworm Lumbricus terrestris: Primary Structures of Linkers L2, L3 and L4 and Analysis of the Connectivity of the Disulfide Bonds in Linker L1."
    Kao W.-Y., Qin J., Fushitani K., Smith S.S., Gorr T.A., Riggs C.K., Knapp J.E., Chait B.T., Riggs A.F.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Lumbricus erythrocruorin at 3.5 A resolution: architecture of a megadalton respiratory complex."
    Royer W.E., Sharma H., Strand K., Knapp J.E., Bhyravbhatla B.
    Structure 14:1167-1177(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS) OF 26-240, DISULFIDE BONDS.
  3. "Structural Basis for Cooperative Oxygen Binding and Bracelet-Assisted Assembly of Lumbricus Terrestris Hemoglobin."
    Chen W.T., Chen Y.C., Liou H.H., Chao C.Y.
    Submitted (APR-2014) to the PDB data bank
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (8.10 ANGSTROMS).

Entry informationi

Entry nameiQ2I742_LUMTE
AccessioniPrimary (citable) accession number: Q2I742
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: March 16, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.