Reviewed, UniProtKB/Swiss-Prot Q2I6W4 (CATA_CALJA)

Names and origin

Protein names

Recommended name:
    Catalase
    EC=1.11.1.6

Gene names

Name:

CAT

Organism

Callithrix jacchus (Common marmoset)

Taxonomic identifier

9483 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Callitrichinae › Callithrix

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells By similarity.
Catalytic activity	2 H(2)O(2) = O(2) + 2 H(2)O.
Cofactor	Heme group By similarity. NADP By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	PeroxisomeBy similarity.
Sequence similarities	Belongs to the catalase family.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Peroxisome
Ligand	Heme Iron Metal-binding NADP
Molecular function	Mitogen Oxidoreductase Peroxidase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 527	526	Catalase		PRO_0000266027
Sites
	Active site	75	1	By similarity
	Active site	148	1	By similarity
	Metal binding	358	1	Iron (heme axial ligand) By similarity
Amino acid modifications
	Modified residue	231	1	Phosphotyrosine By similarity
	Modified residue	308	1	Phosphotyrosine By similarity
	Modified residue	422	1	Phosphoserine By similarity
	Modified residue	517	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2I6W4-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 437902E9E785C1EA	FASTA	527	59,800
	10 20 30 40 50 60 MADSRDPASD QMKHWKEQRA AQKADVLTTG AGNPVGDKLN VITAGPRGPL LVQDVVFTDE 70 80 90 100 110 120 MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITKYSKAKVF EHIGKRTPIA VRFSTVAGES 130 140 150 160 170 180 GSADTVRDPR GFAVKFYTED GNWDLVGNNT PIFFIRDPLL FPSFIHSQKR NPQTHLKHPD 190 200 210 220 230 240 MVWDFWSLRP ESLHQVSFLF SDRGIPDGHR HMNGYGSHTF KLVNANGEAV YCKFHYKTDQ 250 260 270 280 290 300 GIKNLSVEDA ARLSQEDPDY GLRDLFNAIA TGNYPSWTFY IQVMTFSQAE TFPFNPFDVT 310 320 330 340 350 360 KIWPHKDYPL IPVGKLVLNR NPVNYFAEVE QIAFDPSNMP PGIEASPDKM LQGRLFSYPD 370 380 390 400 410 420 THRHRLGPNY LQIPVNCPYR ARVANYQRDG PMCMQDNQGG APNYYPNSFG APEHQPSALE 430 440 450 460 470 480 HSTRCSAEVQ RFNTANDDNV TQVRAFYVNV LNEEQRKRLC ENIAGHLKDA QLFIQKKAVK 490 500 510 520 NFREVHNDYG TRIQALLDKY NAEKPKNAIH TFVQSGSHLA AREKANL

References

[1]	"Free radical scavenging enzymes in Callithrix jacchus." Atanasova S., von Ahsen N., Schlumbohm C., Wieland E., Oellerich M., Armstrong V. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ241811 mRNA. Translation: ABB71446.1.
3D structure databases
SMR	Q2I6W4. Positions 5-501.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q2I6W4.
Family and domain databases
InterPro	IPR002226. Catalase. IPR011614. Catalase_N. [Graphical view]
Gene3D	G3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHER	PTHR11465. Catalase. 1 hit.
Pfam	PF00199. Catalase. 1 hit. [Graphical view]
PRINTS	PR00067. CATALASE.
ProDom	PD000510. Catalase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATA_CALJA

Accession

Primary (citable) accession number: Q2I6W4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 18 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)