Q2I2Q9 (CO271_CONLT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Conotoxin Lt7.1 Alternative name(s): Lt7a
Organism	Conus litteratus (Lettered cone)
Taxonomic identifier	89445 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Hypsogastropoda › Neogastropoda › Conoidea › Conidae › Conus

Protein attributes

Sequence length	77 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom duct.
Domain	The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity. The cysteine framework is VI/VII (C-C-CC-C-C).
Sequence similarities	Belongs to the conotoxin O2 superfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Knottin Signal
Molecular function	Toxin
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ion channel inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 49	30	Probable		PRO_0000315502
	Peptide	50 – 77	28	Conotoxin Lt7.1		PRO_0000315503
Amino acid modifications
	Disulfide bond	51 ↔ 65		By similarity
	Disulfide bond	58 ↔ 69		By similarity
	Disulfide bond	64 ↔ 74		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2I2Q9 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 0298B88C393E8710	FASTA	77	8,689
	10 20 30 40 50 60 MEKLTILLLV AALLMSTQGL IQSGGENRPK EKIKFLSKRK TVAESWWEGE CLGWSNYCTS 70 HSICCSGECI LSYCDIW

References

[1]

"Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus." Pi C., Liu J., Peng C., Liu Y., Jiang X., Zhao Y., Tang S., Wang L., Dong M., Chen S., Xu A. Genomics 88:809-819(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom duct.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ345373 mRNA. Translation: ABC74981.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ConoServer	1159. LtVIIA precursor.
Family and domain databases
InterPro	IPR004214. Conotoxin. [Graphical view]
Pfam	PF02950. Conotoxin. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CO271_CONLT

Accession

Primary (citable) accession number: Q2I2Q9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	October 3, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program