Unreviewed, UniProtKB/TrEMBL Q2I0Y7 (Q2I0Y7_HUMAN)

Names and origin

Protein names	Submitted name:     Casein kinase 2 alpha isoform EMBL ABC86794.1
Organism	Homo sapiens (Human) EMBL ABC86794.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily.

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304V2 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase RuleBase RU000305V3 Transferase
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q2I0Y7-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 5CD28A4C0211C46B	FASTA	385	45,281
	10 20 30 40 50 60 MSGPVPSRAR VYTDVNTHRP REYWDYESHV VEWGNQDDYQ LVRKLGRGKY SEVFEAINIT 70 80 90 100 110 120 NNEKVVVKIL KPVKKKKIKR EIKILENLRG GPNIITLADI VKDPVSRTPA LVFEHVNNTD 130 140 150 160 170 180 FKQLYQALTD YDIRFYMYEI LKALDYCHSM GIMHRDVKPH NVMIDHEHRK LRLIDWGLAE 190 200 210 220 230 240 FYHPGQEYNV RVASRYFKGP ELLVDYQMYD YSLDMWSLGC MLASMIFRKE PFFHGHDNYD 250 260 270 280 290 300 QLVRIAKVLG TEDLYDYIDK YNIELDPRFN DILGRHSRKR WERFVHSENQ HLVSPEALDF 310 320 330 340 350 360 LDKLLRYDHQ SRLTAREAME HPYFYTVVKD QARMGSSSMP GGSTPVSSAN MMSEMKFCRV 370 380 AQAGLELLSS TVYPPWPPKV LRLEA

References

[1]	"A novel casein kinase 2 alpha-subunit regulates membrane protein traffic in the human hepatoma cell line HuH-7." Shi X., Potvin B., Huang T., Hilgard P., Spray D.C., Suadicani S.O., Wolkoff A.W., Stanley P., Stockert R.J. J. Biol. Chem. 276:2075-2082(2001) [PubMed: 11038365] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Shi X., Potvin B., Huang T., Spray D.C., Suadicani S.O., Wolkoff A.W., Stanley P., Stockert R.J. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ354583 mRNA. Translation: ABC86794.1.
IPI	IPI00741317.
UniGene	Hs.644056
3D structure databases
SMR	Q2I0Y7. Positions 2-337.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2I0Y7.
Proteomic databases
PeptideAtlas	Q2I0Y7.
PRIDE	Q2I0Y7.
Genome annotation databases
Ensembl	ENST00000400227; ENSP00000383086; ENSG00000101266; Homo sapiens. [Genome view]
Organism-specific databases
HGNC	HGNC:2457. CSNK2A1. HGNC:2458. CSNK2A1P.
Phylogenomic databases
HOVERGEN	Q2I0Y7.
PhylomeDB	Q2I0Y7.
Gene expression databases
ArrayExpress	Q2I0Y7.
Bgee	Q2I0Y7.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q2I0Y7_HUMAN

Accession

Primary (citable) accession number: Q2I0Y7

Entry history

Integrated into UniProtKB/TrEMBL:	March 7, 2006
Last sequence update:	March 7, 2006
Last modified:	January 19, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.