LRRC26

Functionⁱ

Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.2 Publications

GO - Molecular functionⁱ

potassium channel regulator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20613726

Complete GO annotation...

GO - Biological processⁱ

ion transport Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	Ion channel
Biological process	Ion transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leucine-rich repeat-containing protein 26 Alternative name(s): BK channel auxiliary gamma subunit LRRC26 Cytokeratin-associated protein in cancer
Gene namesⁱ	Name:LRRC26 Synonyms:CAPC
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31409. LRRC26.

HGNCⁱ

HGNC:31409. LRRC26.

Subcellular locationⁱ

Note:

Localizes to the cytoplasm when expressed at high levels.1 Publication

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	27 – 261	ExtracellularSequence analysisAdd BLAST	235
Transmembraneⁱ	262 – 282	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	283 – 334	CytoplasmicSequence analysisAdd BLAST	52

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-KW
cytoskeleton Source: UniProtKB-SubCell
extracellular exosome
Source: UniProtKB
Inferred from direct assayⁱ
- 19199708
fibrillar center Source: HPA
nucleolus Source: HPA
plasma membrane Source: HPA
voltage-gated potassium channel complex
Source: UniProtKB
Inferred from direct assayⁱ
- 20613726

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	389816.
Open Targets More...OpenTargetsⁱ	ENSG00000184709.
PharmGKBⁱ	PA134952867.

Polymorphism and mutation databases

BioMutaⁱ	LRRC26.
DMDMⁱ	160410009.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Add BLAST		26
ChainⁱPRO_0000309360	27 – 334	Leucine-rich repeat-containing protein 26Add BLAST		308

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	43 ↔ 49	Sequence analysis
Disulfide bondⁱ	47 ↔ 57	Sequence analysis
Glycosylationⁱ	147	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	205 ↔ 231	Sequence analysis
Disulfide bondⁱ	207 ↔ 253	Sequence analysis

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q2I0M4.
PaxDbⁱ	Q2I0M4.
PeptideAtlas More...PeptideAtlasⁱ	Q2I0M4.
PRIDEⁱ	Q2I0M4.

PTM databases

iPTMnetⁱ	Q2I0M4.
PhosphoSitePlusⁱ	Q2I0M4.

Expressionⁱ

Tissue specificityⁱ

Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000184709.
CleanExⁱ	HS_LRRC26.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA056312.

HPAⁱ

HPA056312.

Interactionⁱ

Subunit structureⁱ

Interacts with KCNMA1.2 Publications

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-60459N.
STRINGⁱ	9606.ENSP00000360597.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q2I0M4.
SMRⁱ	Q2I0M4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	34 – 71	LRRNTAdd BLAST	38
Repeatⁱ	72 – 93	LRR 1Add BLAST	22
Repeatⁱ	96 – 117	LRR 2Add BLAST	22
Repeatⁱ	120 – 141	LRR 3Add BLAST	22
Repeatⁱ	144 – 167	LRR 4Add BLAST	24
Repeatⁱ	168 – 190	LRR 5Add BLAST	23
Domainⁱ	201 – 255	LRRCTAdd BLAST	55

Domainⁱ

The transmembrane domain is necessary for interaction with KCNMA1.

Keywords - Domainⁱ

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0619. Eukaryota. COG4886. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137863.
HOGENOMⁱ	HOG000113367.
HOVERGENⁱ	HBG096585.
InParanoidⁱ	Q2I0M4.
OMAⁱ	DAAFSHC.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G9Q.
PhylomeDBⁱ	Q2I0M4.
TreeFamⁱ	TF334689.

Family and domain databases

Gene3Dⁱ	3.80.10.10. 2 hits.
InterProⁱ	View protein in InterPro IPR032675. L_dom-like. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13855. LRR_8. 2 hits.
SMARTⁱ	View protein in SMART SM00369. LRR_TYP. 5 hits.
SUPFAMⁱ	SSF52058. SSF52058. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q2I0M4-1) [UniParc]FASTA Add to basket

Also known as: L-CAPC

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGPSWSRPR PLLLLLLLLS PWPVWAQVSA TASPSGSLGA PDCPEVCTCV 
        60         70         80         90        100
PGGLASCSAL SLPAVPPGLS LRLRALLLDH NRVRALPPGA FAGAGALQRL 
       110        120        130        140        150
DLRENGLHSV HVRAFWGLGA LQLLDLSANQ LEALAPGTFA PLRALRNLSL 
       160        170        180        190        200
AGNRLARLEP AALGALPLLR SLSLQDNELA ALAPGLLGRL PALDALHLRG 
       210        220        230        240        250
NPWGCGCALR PLCAWLRRHP LPASEAETVL CVWPGRLTLS PLTAFSDAAF 
       260        270        280        290        300
SHCAQPLALR DLAVVYTLGP ASFLVSLASC LALGSGLTAC RARRRRLRTA 
       310        320        330 
ALRPPRPPDP NPDPDPHGCA SPADPGSPAA AAQA

Length:334

Mass (Da):34,857

Last modified:November 13, 2007 - v2

Checksum:ⁱB3E8C6C9AADEF958

GO

Isoform 2 (identifier: Q2I0M4-2) [UniParc]FASTA Add to basket

Also known as: S-CAPC

The sequence of this isoform differs from the canonical sequence as follows:
1-289: Missing.
290-290: C → M

« Hide

        10         20         30         40 
MRARRRRLRT AALRPPRPPD PNPDPDPHGC ASPADPGSPA AAAQA

Note: Translation initiates from a UGC codon. It is unsure whether the initiator amino acid is a modified cysteine or a methionine. Could also be the result of a proteolytic cleavage from a longer precursor.

Show »

Length:45

Mass (Da):4,736

Checksum:ⁱD7AC871D6CE8057F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	27	Q → H in ABC79623 (PubMed:16585525).Curated		1
Sequence conflictⁱ	27	Q → H in AAI40912 (PubMed:15164053).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_040058	1 – 289	Missing in isoform 2. 1 PublicationAdd BLAST		289
Alternative sequenceⁱVSP_040205	290	C → M in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ355157 mRNA. Translation: ABC79623.1. EU588721 mRNA. Translation: ACO90295.1. AL929554 Genomic DNA. Translation: CAH72880.1. BC140911 mRNA. Translation: AAI40912.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35184.1. [Q2I0M4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001013675.1. NM_001013653.2. [Q2I0M4-1]
UniGeneⁱ	Hs.669977.

Genome annotation databases

Ensemblⁱ	ENST00000371542; ENSP00000360597; ENSG00000184709. [Q2I0M4-1]
GeneIDⁱ	389816.
KEGGⁱ	hsa:389816.
UCSC genome browser More...UCSCⁱ	uc004clp.4. human. [Q2I0M4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ355157 mRNA. Translation: ABC79623.1. EU588721 mRNA. Translation: ACO90295.1. AL929554 Genomic DNA. Translation: CAH72880.1. BC140911 mRNA. Translation: AAI40912.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35184.1. [Q2I0M4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001013675.1. NM_001013653.2. [Q2I0M4-1]
UniGeneⁱ	Hs.669977.

3D structure databases

ProteinModelPortalⁱ	Q2I0M4.
SMRⁱ	Q2I0M4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-60459N.
STRINGⁱ	9606.ENSP00000360597.

PTM databases

iPTMnetⁱ	Q2I0M4.
PhosphoSitePlusⁱ	Q2I0M4.

Polymorphism and mutation databases

BioMutaⁱ	LRRC26.
DMDMⁱ	160410009.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q2I0M4.
PaxDbⁱ	Q2I0M4.
PeptideAtlas More...PeptideAtlasⁱ	Q2I0M4.
PRIDEⁱ	Q2I0M4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000371542; ENSP00000360597; ENSG00000184709. [Q2I0M4-1]
GeneIDⁱ	389816.
KEGGⁱ	hsa:389816.
UCSC genome browser More...UCSCⁱ	uc004clp.4. human. [Q2I0M4-1]

Organism-specific databases

CTDⁱ	389816.
DisGeNET More...DisGeNETⁱ	389816.
GeneCardsⁱ	LRRC26.
H-InvDBⁱ	HIX0035220.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31409. LRRC26.
Human Protein Atlas More...HPAⁱ	HPA056312.
MIMⁱ	613505. gene.
neXtProtⁱ	NX_Q2I0M4.
Open Targets More...OpenTargetsⁱ	ENSG00000184709.
PharmGKBⁱ	PA134952867.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0619. Eukaryota. COG4886. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137863.
HOGENOMⁱ	HOG000113367.
HOVERGENⁱ	HBG096585.
InParanoidⁱ	Q2I0M4.
OMAⁱ	DAAFSHC.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G9Q.
PhylomeDBⁱ	Q2I0M4.
TreeFamⁱ	TF334689.

Miscellaneous databases

ChiTaRSⁱ	LRRC26. human.
GenomeRNAiⁱ	389816.
Protein Ontology More...PROⁱ	PR:Q2I0M4.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000184709.
CleanExⁱ	HS_LRRC26.

Family and domain databases

Gene3Dⁱ	3.80.10.10. 2 hits.
InterProⁱ	View protein in InterPro IPR032675. L_dom-like. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13855. LRR_8. 2 hits.
SMARTⁱ	View protein in SMART SM00369. LRR_TYP. 5 hits.
SUPFAMⁱ	SSF52058. SSF52058. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LRC26_HUMAN
Accessionⁱ	Q2I0M4Primary (citable) accession number: Q2I0M4 Secondary accession number(s): B9EIR7, C3RUL3, Q5VSG2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	November 13, 2007
	Last modified:	June 7, 2017
	This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q2I0M4 (LRC26_HUMAN)

Your basket is currently empty.

Leucine-rich repeat-containing protein 26

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ