UniProtKB - Q2I0M4 (LRC26_HUMAN)
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Protein
Leucine-rich repeat-containing protein 26
Gene
LRRC26
Organism
Homo sapiens (Human)
Status
Functioni
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.2 Publications
GO - Molecular functioni
- ion channel binding Source: UniProtKB
- potassium channel activator activity Source: UniProtKB
- potassium channel regulator activity Source: UniProtKB
- voltage-gated potassium channel activity Source: UniProtKB
GO - Biological processi
- positive regulation of voltage-gated potassium channel activity Source: UniProtKB
- potassium ion transmembrane transport Source: UniProtKB
Keywordsi
Molecular function | Ion channel |
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat-containing protein 26Alternative name(s): BK channel auxiliary gamma subunit LRRC26 Cytokeratin-associated protein in cancer |
Gene namesi | Name:LRRC26 Synonyms:CAPC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000184709.7. |
HGNCi | HGNC:31409. LRRC26. |
MIMi | 613505. gene. |
neXtProti | NX_Q2I0M4. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 261 | ExtracellularSequence analysisAdd BLAST | 235 | |
Transmembranei | 262 – 282 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 283 – 334 | CytoplasmicSequence analysisAdd BLAST | 52 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 389816. |
OpenTargetsi | ENSG00000184709. |
PharmGKBi | PA134952867. |
Polymorphism and mutation databases
BioMutai | LRRC26. |
DMDMi | 160410009. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Add BLAST | 26 | |
ChainiPRO_0000309360 | 27 – 334 | Leucine-rich repeat-containing protein 26Add BLAST | 308 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 43 ↔ 49 | Sequence analysis | ||
Disulfide bondi | 47 ↔ 57 | Sequence analysis | ||
Glycosylationi | 147 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 205 ↔ 231 | Sequence analysis | ||
Disulfide bondi | 207 ↔ 253 | Sequence analysis |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | Q2I0M4. |
PaxDbi | Q2I0M4. |
PeptideAtlasi | Q2I0M4. |
PRIDEi | Q2I0M4. |
PTM databases
iPTMneti | Q2I0M4. |
PhosphoSitePlusi | Q2I0M4. |
Expressioni
Tissue specificityi
Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines.2 Publications
Gene expression databases
Bgeei | ENSG00000184709. |
CleanExi | HS_LRRC26. |
Organism-specific databases
HPAi | HPA056312. |
Interactioni
Subunit structurei
Interacts with KCNMA1.2 Publications
Binary interactionsi
GO - Molecular functioni
- ion channel binding Source: UniProtKB
Protein-protein interaction databases
CORUMi | Q2I0M4. |
DIPi | DIP-60459N. |
IntActi | Q2I0M4. 1 interactor. |
STRINGi | 9606.ENSP00000360597. |
Structurei
3D structure databases
ProteinModelPortali | Q2I0M4. |
SMRi | Q2I0M4. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 71 | LRRNTAdd BLAST | 38 | |
Repeati | 72 – 93 | LRR 1Add BLAST | 22 | |
Repeati | 96 – 117 | LRR 2Add BLAST | 22 | |
Repeati | 120 – 141 | LRR 3Add BLAST | 22 | |
Repeati | 144 – 167 | LRR 4Add BLAST | 24 | |
Repeati | 168 – 190 | LRR 5Add BLAST | 23 | |
Domaini | 201 – 255 | LRRCTAdd BLAST | 55 |
Domaini
The transmembrane domain is necessary for interaction with KCNMA1.
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0619. Eukaryota. COG4886. LUCA. |
GeneTreei | ENSGT00880000137863. |
HOGENOMi | HOG000113367. |
HOVERGENi | HBG096585. |
InParanoidi | Q2I0M4. |
OMAi | DAAFSHC. |
OrthoDBi | EOG091G0G9Q. |
PhylomeDBi | Q2I0M4. |
TreeFami | TF334689. |
Family and domain databases
Gene3Di | 3.80.10.10. 1 hit. |
InterProi | View protein in InterPro IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR032675. LRR_dom_sf. |
Pfami | View protein in Pfam PF13855. LRR_8. 2 hits. |
SMARTi | View protein in SMART SM00369. LRR_TYP. 5 hits. |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q2I0M4-1) [UniParc]FASTAAdd to basket
Also known as: L-CAPC
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MRGPSWSRPR PLLLLLLLLS PWPVWAQVSA TASPSGSLGA PDCPEVCTCV
60 70 80 90 100
PGGLASCSAL SLPAVPPGLS LRLRALLLDH NRVRALPPGA FAGAGALQRL
110 120 130 140 150
DLRENGLHSV HVRAFWGLGA LQLLDLSANQ LEALAPGTFA PLRALRNLSL
160 170 180 190 200
AGNRLARLEP AALGALPLLR SLSLQDNELA ALAPGLLGRL PALDALHLRG
210 220 230 240 250
NPWGCGCALR PLCAWLRRHP LPASEAETVL CVWPGRLTLS PLTAFSDAAF
260 270 280 290 300
SHCAQPLALR DLAVVYTLGP ASFLVSLASC LALGSGLTAC RARRRRLRTA
310 320 330
ALRPPRPPDP NPDPDPHGCA SPADPGSPAA AAQA
Isoform 2 (identifier: Q2I0M4-2) [UniParc]FASTAAdd to basket
Also known as: S-CAPC
The sequence of this isoform differs from the canonical sequence as follows:
1-289: Missing.
290-290: C → M
Note: Translation initiates from a UGC codon. It is unsure whether the initiator amino acid is a modified cysteine or a methionine. Could also be the result of a proteolytic cleavage from a longer precursor.
Show »Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 | Q → H in ABC79623 (PubMed:16585525).Curated | 1 | |
Sequence conflicti | 27 | Q → H in AAI40912 (PubMed:15164053).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040058 | 1 – 289 | Missing in isoform 2. 1 PublicationAdd BLAST | 289 | |
Alternative sequenceiVSP_040205 | 290 | C → M in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ355157 mRNA. Translation: ABC79623.1. EU588721 mRNA. Translation: ACO90295.1. AL929554 Genomic DNA. No translation available. BC140911 mRNA. Translation: AAI40912.1. |
CCDSi | CCDS35184.1. [Q2I0M4-1] |
RefSeqi | NP_001013675.1. NM_001013653.2. [Q2I0M4-1] |
UniGenei | Hs.669977. |
Genome annotation databases
Ensembli | ENST00000371542; ENSP00000360597; ENSG00000184709. [Q2I0M4-1] |
GeneIDi | 389816. |
KEGGi | hsa:389816. |
UCSCi | uc004clp.4. human. [Q2I0M4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | LRC26_HUMAN | |
Accessioni | Q2I0M4Primary (citable) accession number: Q2I0M4 Secondary accession number(s): B9EIR7, C3RUL3, Q5VSG2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | November 13, 2007 | |
Last modified: | February 28, 2018 | |
This is version 103 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |