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Protein

Leucine-rich repeat-containing protein 26

Gene

LRRC26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.2 Publications

GO - Molecular functioni

  • potassium channel regulator activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 26
Alternative name(s):
BK channel auxiliary gamma subunit LRRC26
Cytokeratin-associated protein in cancer
Gene namesi
Name:LRRC26
Synonyms:CAPC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:31409. LRRC26.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 261ExtracellularSequence analysisAdd BLAST235
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 334CytoplasmicSequence analysisAdd BLAST52

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • voltage-gated potassium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi389816.
OpenTargetsiENSG00000184709.
PharmGKBiPA134952867.

Polymorphism and mutation databases

BioMutaiLRRC26.
DMDMi160410009.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000030936027 – 334Leucine-rich repeat-containing protein 26Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 49Sequence analysis
Disulfide bondi47 ↔ 57Sequence analysis
Glycosylationi147N-linked (GlcNAc...)1 Publication1
Disulfide bondi205 ↔ 231Sequence analysis
Disulfide bondi207 ↔ 253Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ2I0M4.
PaxDbiQ2I0M4.
PeptideAtlasiQ2I0M4.
PRIDEiQ2I0M4.

PTM databases

iPTMnetiQ2I0M4.
PhosphoSitePlusiQ2I0M4.

Expressioni

Tissue specificityi

Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines.2 Publications

Gene expression databases

BgeeiENSG00000184709.
CleanExiHS_LRRC26.

Organism-specific databases

HPAiHPA056312.

Interactioni

Subunit structurei

Interacts with KCNMA1.2 Publications

Protein-protein interaction databases

DIPiDIP-60459N.
STRINGi9606.ENSP00000360597.

Structurei

3D structure databases

ProteinModelPortaliQ2I0M4.
SMRiQ2I0M4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 71LRRNTAdd BLAST38
Repeati72 – 93LRR 1Add BLAST22
Repeati96 – 117LRR 2Add BLAST22
Repeati120 – 141LRR 3Add BLAST22
Repeati144 – 167LRR 4Add BLAST24
Repeati168 – 190LRR 5Add BLAST23
Domaini201 – 255LRRCTAdd BLAST55

Domaini

The transmembrane domain is necessary for interaction with KCNMA1.

Sequence similaritiesi

Contains 5 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00850000132257.
HOGENOMiHOG000113367.
HOVERGENiHBG096585.
InParanoidiQ2I0M4.
OMAiDAAFSHC.
OrthoDBiEOG091G0G9Q.
PhylomeDBiQ2I0M4.
TreeFamiTF334689.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2I0M4-1) [UniParc]FASTAAdd to basket
Also known as: L-CAPC

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGPSWSRPR PLLLLLLLLS PWPVWAQVSA TASPSGSLGA PDCPEVCTCV
60 70 80 90 100
PGGLASCSAL SLPAVPPGLS LRLRALLLDH NRVRALPPGA FAGAGALQRL
110 120 130 140 150
DLRENGLHSV HVRAFWGLGA LQLLDLSANQ LEALAPGTFA PLRALRNLSL
160 170 180 190 200
AGNRLARLEP AALGALPLLR SLSLQDNELA ALAPGLLGRL PALDALHLRG
210 220 230 240 250
NPWGCGCALR PLCAWLRRHP LPASEAETVL CVWPGRLTLS PLTAFSDAAF
260 270 280 290 300
SHCAQPLALR DLAVVYTLGP ASFLVSLASC LALGSGLTAC RARRRRLRTA
310 320 330
ALRPPRPPDP NPDPDPHGCA SPADPGSPAA AAQA
Length:334
Mass (Da):34,857
Last modified:November 13, 2007 - v2
Checksum:iB3E8C6C9AADEF958
GO
Isoform 2 (identifier: Q2I0M4-2) [UniParc]FASTAAdd to basket
Also known as: S-CAPC

The sequence of this isoform differs from the canonical sequence as follows:
     1-289: Missing.
     290-290: C → M

Note: Translation initiates from a UGC codon. It is unsure whether the initiator amino acid is a modified cysteine or a methionine. Could also be the result of a proteolytic cleavage from a longer precursor.
Show »
Length:45
Mass (Da):4,736
Checksum:iD7AC871D6CE8057F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27Q → H in ABC79623 (PubMed:16585525).Curated1
Sequence conflicti27Q → H in AAI40912 (PubMed:15164053).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0400581 – 289Missing in isoform 2. 1 PublicationAdd BLAST289
Alternative sequenceiVSP_040205290C → M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ355157 mRNA. Translation: ABC79623.1.
EU588721 mRNA. Translation: ACO90295.1.
AL929554 Genomic DNA. Translation: CAH72880.1.
BC140911 mRNA. Translation: AAI40912.1.
CCDSiCCDS35184.1. [Q2I0M4-1]
RefSeqiNP_001013675.1. NM_001013653.2. [Q2I0M4-1]
UniGeneiHs.669977.

Genome annotation databases

EnsembliENST00000371542; ENSP00000360597; ENSG00000184709. [Q2I0M4-1]
GeneIDi389816.
KEGGihsa:389816.
UCSCiuc004clp.4. human. [Q2I0M4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ355157 mRNA. Translation: ABC79623.1.
EU588721 mRNA. Translation: ACO90295.1.
AL929554 Genomic DNA. Translation: CAH72880.1.
BC140911 mRNA. Translation: AAI40912.1.
CCDSiCCDS35184.1. [Q2I0M4-1]
RefSeqiNP_001013675.1. NM_001013653.2. [Q2I0M4-1]
UniGeneiHs.669977.

3D structure databases

ProteinModelPortaliQ2I0M4.
SMRiQ2I0M4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60459N.
STRINGi9606.ENSP00000360597.

PTM databases

iPTMnetiQ2I0M4.
PhosphoSitePlusiQ2I0M4.

Polymorphism and mutation databases

BioMutaiLRRC26.
DMDMi160410009.

Proteomic databases

MaxQBiQ2I0M4.
PaxDbiQ2I0M4.
PeptideAtlasiQ2I0M4.
PRIDEiQ2I0M4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371542; ENSP00000360597; ENSG00000184709. [Q2I0M4-1]
GeneIDi389816.
KEGGihsa:389816.
UCSCiuc004clp.4. human. [Q2I0M4-1]

Organism-specific databases

CTDi389816.
DisGeNETi389816.
GeneCardsiLRRC26.
H-InvDBHIX0035220.
HGNCiHGNC:31409. LRRC26.
HPAiHPA056312.
MIMi613505. gene.
neXtProtiNX_Q2I0M4.
OpenTargetsiENSG00000184709.
PharmGKBiPA134952867.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00850000132257.
HOGENOMiHOG000113367.
HOVERGENiHBG096585.
InParanoidiQ2I0M4.
OMAiDAAFSHC.
OrthoDBiEOG091G0G9Q.
PhylomeDBiQ2I0M4.
TreeFamiTF334689.

Miscellaneous databases

ChiTaRSiLRRC26. human.
GenomeRNAii389816.
PROiQ2I0M4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184709.
CleanExiHS_LRRC26.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLRC26_HUMAN
AccessioniPrimary (citable) accession number: Q2I0M4
Secondary accession number(s): B9EIR7, C3RUL3, Q5VSG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.