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Q2HZD7

- Q2HZD7_CHICK

UniProt

Q2HZD7 - Q2HZD7_CHICK

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Protein
Submitted name:

Receptor tyrosine-protein kinase

Gene

erbB3

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. receptor signaling protein tyrosine kinase activity Source: InterPro
  3. transmembrane receptor protein tyrosine kinase activity Source: InterPro

GO - Biological processi

  1. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorImported, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor tyrosine-protein kinaseImported
Gene namesi
Name:erbB3Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ2HZD7.
SMRiQ2HZD7. Positions 29-632, 688-980.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG000490.
KOiK05084.
PhylomeDBiQ2HZD7.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 5 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2HZD7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRSRFRPRA LLCAVLLLLL HSPAPGSGQA VCAGTLNGLS VTGDAQHQYR
60 70 80 90 100
TLHKMYNNCE IVMGNLEIVL IDHTQDLSFL QTIREVTGYI LIAMNVFSTL
110 120 130 140 150
PLRNLRVIRG TQFYEEKYAL FVLLNYNPNA THALRQLGLN RLTEILAGGV
160 170 180 190 200
YIEKNEQLCH VDTVEWRDIM RDPRLEPVVG DNGRACAPCH ESCGGHCWGP
210 220 230 240 250
GPEDCQQLTK TICAPQCNGR CFGRAPNECC HEECAGGCTG PLQTHCFACR
260 270 280 290 300
HFNDSGACVP LCPQPLIYNK LTFQLEPNPD TKYQYGSVCV RSCPHNFVVD
310 320 330 340 350
QSSCVRACPS NKMEVEKNGL KMCEPCAGLC PKACEGTGAG SHYQTVDSSN
360 370 380 390 400
IDSFVNCTKI LGNLDFLITG LEGDPWRNIS ALDPEKLNVF RTVREITGYL
410 420 430 440 450
NIQSWPKHMH NFSVFSNLET IGGRSLYNRG FSLLIMKNDN VTSLGLRSLR
460 470 480 490 500
EVSAGRVYIT ENRRLCYLHT VQWAALSRRR ADLDIRNNKP RGKCQQEGKV
510 520 530 540 550
CDPLCSADGC WGPGPAQCLS CRHYSRRGVC VESCSFTQGE TREFAEGTEC
560 570 580 590 600
FECHPECERV EGGITCNGSG ADTCTRCAHY RDGPHCVERC PEGILGERGP
610 620 630 640 650
IYKYPDSSRE CRPCHENCTR GCTGPLLQDC LGDALPSARR APTVIAVLVV
660 670 680 690 700
GGLFLSCSCV LLSLLYWRGK KIQKKRAMRR YLERGESLEP LDPSEKANKV
710 720 730 740 750
LARIFKETEL KRLKVLGSGV FGTVHKGIWI PDGDSIKIPV SIKVIQDWSG
760 770 780 790 800
QQSFHAVTDH MLAIGSLDHA YIVRLLGICP GPQLQLVTQL LPLGSLLDYV
810 820 830 840 850
RKNRGSISPQ LLLNWCVQVA KGMYYLEEHR MVHRNLAARN VLLKSPSQAQ
860 870 880 890 900
VADFGIADLL YPDDKKYFYN EVKTPIKWMA LESIHFGKYT HQSDVWSYGV
910 920 930 940 950
TLWEMMTFGA EPYAGIRLPE VPDLLEKGER LPQPHICTID VYMVMVKCWM
960 970 980 990 1000
IDENIRPTFK ELANEFTRMA RDPPRYLVIK ESGAVPPAEP PTLSDKELDE
1010 1020 1030 1040 1050
METLELEEEE LDVSFGLCPP RPRGSCTRSP SLLSPPAGYI PMNQPGLGSR
1060 1070 1080 1090 1100
QGTGTRPPRR SRQESVGRTV SESSEGRGTA SELDLAEGLS LSGSLCRSLR
1110 1120 1130 1140 1150
SRGDSAYLSQ RESFPPPPPG SEGSEEDANG YVTPSCAGRE PGPTGGSVPE
1160 1170 1180 1190 1200
LEEEYEYMNR QPGAPLQAPP PRPASLEELG YEYMEVGSEL GSPAGPPQSR
1210 1220 1230 1240 1250
GEEEEDYEYM NKQPRLSRSL GNVVGGLGPR HESCPPRHDG YTDMRPGEPT
1260 1270 1280 1290 1300
PAPPEEQGYE EMEAVLAPRG PPCPGCRSPP GPPPTCMKPL RSLEASDCAF
1310
DNPDYWHSRL FAKVDAQRT
Length:1,319
Mass (Da):146,222
Last modified:March 7, 2006 - v1
Checksum:iD6E487257700A0B2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ358720 mRNA. Translation: ABC88378.1.
RefSeqiNP_001038134.1. NM_001044669.1.
UniGeneiGga.33709.

Genome annotation databases

GeneIDi693245.
KEGGigga:693245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ358720 mRNA. Translation: ABC88378.1 .
RefSeqi NP_001038134.1. NM_001044669.1.
UniGenei Gga.33709.

3D structure databases

ProteinModelPortali Q2HZD7.
SMRi Q2HZD7. Positions 29-632, 688-980.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 693245.
KEGGi gga:693245.

Organism-specific databases

CTDi 2065.

Phylogenomic databases

HOVERGENi HBG000490.
KOi K05084.
PhylomeDBi Q2HZD7.

Miscellaneous databases

NextBioi 20902513.
PROi Q2HZD7.

Family and domain databases

Gene3Di 3.80.20.20. 2 hits.
InterProi IPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view ]
Pfami PF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view ]
PIRSFi PIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00261. FU. 5 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of Chicken erbB-3 and Characterization of its Expression in the Chicken Ovary."
    Wang Y., Li J., Leung F.C.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ2HZD7_CHICK
AccessioniPrimary (citable) accession number: Q2HZD7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)