Q2HZD7 (Q2HZD7_CHICK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Receptor tyrosine-protein kinase EMBL ABC88378.1

Gene names

Name:

erbB3 EMBL ABC88378.1

Organism

Gallus gallus (Chicken) EMBL ABC88378.1

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	1319 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Sequence similarities	Contains 1 protein kinase domain. SAAS SAAS009030

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS009030 Nucleotide-binding
Molecular function	Kinase Receptor EMBL ABC88378.1 Transferase Tyrosine-protein kinase SAAS SAAS009030
PTM	Phosphoprotein SAAS SAAS009030
Gene Ontology (GO)
Biological_process	signal transduction by phosphorylation Inferred from electronic annotation. Source: GOC transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW receptor signaling protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q2HZD7 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: D6E487257700A0B2	FASTA	1,319	146,222
	10 20 30 40 50 60 MPRSRFRPRA LLCAVLLLLL HSPAPGSGQA VCAGTLNGLS VTGDAQHQYR TLHKMYNNCE 70 80 90 100 110 120 IVMGNLEIVL IDHTQDLSFL QTIREVTGYI LIAMNVFSTL PLRNLRVIRG TQFYEEKYAL 130 140 150 160 170 180 FVLLNYNPNA THALRQLGLN RLTEILAGGV YIEKNEQLCH VDTVEWRDIM RDPRLEPVVG 190 200 210 220 230 240 DNGRACAPCH ESCGGHCWGP GPEDCQQLTK TICAPQCNGR CFGRAPNECC HEECAGGCTG 250 260 270 280 290 300 PLQTHCFACR HFNDSGACVP LCPQPLIYNK LTFQLEPNPD TKYQYGSVCV RSCPHNFVVD 310 320 330 340 350 360 QSSCVRACPS NKMEVEKNGL KMCEPCAGLC PKACEGTGAG SHYQTVDSSN IDSFVNCTKI 370 380 390 400 410 420 LGNLDFLITG LEGDPWRNIS ALDPEKLNVF RTVREITGYL NIQSWPKHMH NFSVFSNLET 430 440 450 460 470 480 IGGRSLYNRG FSLLIMKNDN VTSLGLRSLR EVSAGRVYIT ENRRLCYLHT VQWAALSRRR 490 500 510 520 530 540 ADLDIRNNKP RGKCQQEGKV CDPLCSADGC WGPGPAQCLS CRHYSRRGVC VESCSFTQGE 550 560 570 580 590 600 TREFAEGTEC FECHPECERV EGGITCNGSG ADTCTRCAHY RDGPHCVERC PEGILGERGP 610 620 630 640 650 660 IYKYPDSSRE CRPCHENCTR GCTGPLLQDC LGDALPSARR APTVIAVLVV GGLFLSCSCV 670 680 690 700 710 720 LLSLLYWRGK KIQKKRAMRR YLERGESLEP LDPSEKANKV LARIFKETEL KRLKVLGSGV 730 740 750 760 770 780 FGTVHKGIWI PDGDSIKIPV SIKVIQDWSG QQSFHAVTDH MLAIGSLDHA YIVRLLGICP 790 800 810 820 830 840 GPQLQLVTQL LPLGSLLDYV RKNRGSISPQ LLLNWCVQVA KGMYYLEEHR MVHRNLAARN 850 860 870 880 890 900 VLLKSPSQAQ VADFGIADLL YPDDKKYFYN EVKTPIKWMA LESIHFGKYT HQSDVWSYGV 910 920 930 940 950 960 TLWEMMTFGA EPYAGIRLPE VPDLLEKGER LPQPHICTID VYMVMVKCWM IDENIRPTFK 970 980 990 1000 1010 1020 ELANEFTRMA RDPPRYLVIK ESGAVPPAEP PTLSDKELDE METLELEEEE LDVSFGLCPP 1030 1040 1050 1060 1070 1080 RPRGSCTRSP SLLSPPAGYI PMNQPGLGSR QGTGTRPPRR SRQESVGRTV SESSEGRGTA 1090 1100 1110 1120 1130 1140 SELDLAEGLS LSGSLCRSLR SRGDSAYLSQ RESFPPPPPG SEGSEEDANG YVTPSCAGRE 1150 1160 1170 1180 1190 1200 PGPTGGSVPE LEEEYEYMNR QPGAPLQAPP PRPASLEELG YEYMEVGSEL GSPAGPPQSR 1210 1220 1230 1240 1250 1260 GEEEEDYEYM NKQPRLSRSL GNVVGGLGPR HESCPPRHDG YTDMRPGEPT PAPPEEQGYE 1270 1280 1290 1300 1310 EMEAVLAPRG PPCPGCRSPP GPPPTCMKPL RSLEASDCAF DNPDYWHSRL FAKVDAQRT

References

[1]	"Cloning of Chicken erbB-3 and Characterization of its Expression in the Chicken Ovary." Wang Y., Li J., Leung F.C. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ358720 mRNA. Translation: ABC88378.1.
IPI	IPI00742555.
RefSeq	NP_001038134.1. NM_001044669.1.
UniGene	Gga.33709.
3D structure databases
ProteinModelPortal	Q2HZD7.
SMR	Q2HZD7. Positions 29-632, 688-980.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	693245.
KEGG	gga:693245.
Organism-specific databases
CTD	2065.
Phylogenomic databases
HOVERGEN	HBG000490.
KO	K05084.
Family and domain databases
Gene3D	3.80.20.20. 2 hits.
InterPro	IPR000494. EGF_rcpt_L. IPR006211. Furin-like_Cys-rich_dom. IPR006212. Furin_repeat. IPR009030. Growth_fac_rcpt_N_dom. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR020635. Tyr_kinase_cat_dom. IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt. [Graphical view]
Pfam	PF00757. Furin-like. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF01030. Recep_L_domain. 2 hits. [Graphical view]
PIRSF	PIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTS	PR00109. TYRKINASE.
SMART	SM00261. FU. 5 hits. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF57184. Grow_fac_recept. 2 hits. SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20902513.

Entry information

Entry name

Q2HZD7_CHICK

Accession

Primary (citable) accession number: Q2HZD7

Entry history

Integrated into UniProtKB/TrEMBL:	March 7, 2006
Last sequence update:	March 7, 2006
Last modified:	May 29, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)