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Q2HZD7

- Q2HZD7_CHICK

UniProt

Q2HZD7 - Q2HZD7_CHICK

Protein
Submitted name:

Receptor tyrosine-protein kinase

Gene

erbB3

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. receptor signaling protein tyrosine kinase activity Source: InterPro
    3. transmembrane receptor protein tyrosine kinase activity Source: InterPro

    GO - Biological processi

    1. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, ReceptorImported, Transferase, Tyrosine-protein kinaseSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Receptor tyrosine-protein kinaseImported
    Gene namesi
    Name:erbB3Imported
    OrganismiGallus gallus (Chicken)Imported
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ2HZD7.
    SMRiQ2HZD7. Positions 29-632, 688-980.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains protein kinase domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG000490.
    KOiK05084.
    PhylomeDBiQ2HZD7.

    Family and domain databases

    Gene3Di3.80.20.20. 2 hits.
    InterProiIPR000494. EGF_rcpt_L.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
    [Graphical view]
    PfamiPF00757. Furin-like. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00261. FU. 5 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2HZD7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRSRFRPRA LLCAVLLLLL HSPAPGSGQA VCAGTLNGLS VTGDAQHQYR     50
    TLHKMYNNCE IVMGNLEIVL IDHTQDLSFL QTIREVTGYI LIAMNVFSTL 100
    PLRNLRVIRG TQFYEEKYAL FVLLNYNPNA THALRQLGLN RLTEILAGGV 150
    YIEKNEQLCH VDTVEWRDIM RDPRLEPVVG DNGRACAPCH ESCGGHCWGP 200
    GPEDCQQLTK TICAPQCNGR CFGRAPNECC HEECAGGCTG PLQTHCFACR 250
    HFNDSGACVP LCPQPLIYNK LTFQLEPNPD TKYQYGSVCV RSCPHNFVVD 300
    QSSCVRACPS NKMEVEKNGL KMCEPCAGLC PKACEGTGAG SHYQTVDSSN 350
    IDSFVNCTKI LGNLDFLITG LEGDPWRNIS ALDPEKLNVF RTVREITGYL 400
    NIQSWPKHMH NFSVFSNLET IGGRSLYNRG FSLLIMKNDN VTSLGLRSLR 450
    EVSAGRVYIT ENRRLCYLHT VQWAALSRRR ADLDIRNNKP RGKCQQEGKV 500
    CDPLCSADGC WGPGPAQCLS CRHYSRRGVC VESCSFTQGE TREFAEGTEC 550
    FECHPECERV EGGITCNGSG ADTCTRCAHY RDGPHCVERC PEGILGERGP 600
    IYKYPDSSRE CRPCHENCTR GCTGPLLQDC LGDALPSARR APTVIAVLVV 650
    GGLFLSCSCV LLSLLYWRGK KIQKKRAMRR YLERGESLEP LDPSEKANKV 700
    LARIFKETEL KRLKVLGSGV FGTVHKGIWI PDGDSIKIPV SIKVIQDWSG 750
    QQSFHAVTDH MLAIGSLDHA YIVRLLGICP GPQLQLVTQL LPLGSLLDYV 800
    RKNRGSISPQ LLLNWCVQVA KGMYYLEEHR MVHRNLAARN VLLKSPSQAQ 850
    VADFGIADLL YPDDKKYFYN EVKTPIKWMA LESIHFGKYT HQSDVWSYGV 900
    TLWEMMTFGA EPYAGIRLPE VPDLLEKGER LPQPHICTID VYMVMVKCWM 950
    IDENIRPTFK ELANEFTRMA RDPPRYLVIK ESGAVPPAEP PTLSDKELDE 1000
    METLELEEEE LDVSFGLCPP RPRGSCTRSP SLLSPPAGYI PMNQPGLGSR 1050
    QGTGTRPPRR SRQESVGRTV SESSEGRGTA SELDLAEGLS LSGSLCRSLR 1100
    SRGDSAYLSQ RESFPPPPPG SEGSEEDANG YVTPSCAGRE PGPTGGSVPE 1150
    LEEEYEYMNR QPGAPLQAPP PRPASLEELG YEYMEVGSEL GSPAGPPQSR 1200
    GEEEEDYEYM NKQPRLSRSL GNVVGGLGPR HESCPPRHDG YTDMRPGEPT 1250
    PAPPEEQGYE EMEAVLAPRG PPCPGCRSPP GPPPTCMKPL RSLEASDCAF 1300
    DNPDYWHSRL FAKVDAQRT 1319
    Length:1,319
    Mass (Da):146,222
    Last modified:March 7, 2006 - v1
    Checksum:iD6E487257700A0B2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ358720 mRNA. Translation: ABC88378.1.
    RefSeqiNP_001038134.1. NM_001044669.1.
    UniGeneiGga.33709.

    Genome annotation databases

    GeneIDi693245.
    KEGGigga:693245.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ358720 mRNA. Translation: ABC88378.1 .
    RefSeqi NP_001038134.1. NM_001044669.1.
    UniGenei Gga.33709.

    3D structure databases

    ProteinModelPortali Q2HZD7.
    SMRi Q2HZD7. Positions 29-632, 688-980.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 693245.
    KEGGi gga:693245.

    Organism-specific databases

    CTDi 2065.

    Phylogenomic databases

    HOVERGENi HBG000490.
    KOi K05084.
    PhylomeDBi Q2HZD7.

    Miscellaneous databases

    NextBioi 20902513.
    PROi Q2HZD7.

    Family and domain databases

    Gene3Di 3.80.20.20. 2 hits.
    InterProi IPR000494. EGF_rcpt_L.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
    [Graphical view ]
    Pfami PF00757. Furin-like. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000619. TyrPK_EGF-R. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00261. FU. 5 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of Chicken erbB-3 and Characterization of its Expression in the Chicken Ovary."
      Wang Y., Li J., Leung F.C.
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ2HZD7_CHICK
    AccessioniPrimary (citable) accession number: Q2HZD7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 7, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)