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Protein
Submitted name:

Receptor tyrosine-protein kinase

Gene

erbB3

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, ReceptorImported, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor tyrosine-protein kinaseImported
Gene namesi
Name:erbB3Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei644 – 667HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500420963529 – 1319Sequence analysisAdd BLAST1291

Structurei

3D structure databases

ProteinModelPortaliQ2HZD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini710 – 967Protein kinaseInterPro annotationAdd BLAST258

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG000490.
KOiK05084.
PhylomeDBiQ2HZD7.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR032778. GF_recep_IV.
IPR009030. Growth_fac_rcpt_.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR000719. Prot_kinase_dom.
IPR000494. Rcpt_L-dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF14843. GF_recep_IV. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2HZD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSRFRPRA LLCAVLLLLL HSPAPGSGQA VCAGTLNGLS VTGDAQHQYR
60 70 80 90 100
TLHKMYNNCE IVMGNLEIVL IDHTQDLSFL QTIREVTGYI LIAMNVFSTL
110 120 130 140 150
PLRNLRVIRG TQFYEEKYAL FVLLNYNPNA THALRQLGLN RLTEILAGGV
160 170 180 190 200
YIEKNEQLCH VDTVEWRDIM RDPRLEPVVG DNGRACAPCH ESCGGHCWGP
210 220 230 240 250
GPEDCQQLTK TICAPQCNGR CFGRAPNECC HEECAGGCTG PLQTHCFACR
260 270 280 290 300
HFNDSGACVP LCPQPLIYNK LTFQLEPNPD TKYQYGSVCV RSCPHNFVVD
310 320 330 340 350
QSSCVRACPS NKMEVEKNGL KMCEPCAGLC PKACEGTGAG SHYQTVDSSN
360 370 380 390 400
IDSFVNCTKI LGNLDFLITG LEGDPWRNIS ALDPEKLNVF RTVREITGYL
410 420 430 440 450
NIQSWPKHMH NFSVFSNLET IGGRSLYNRG FSLLIMKNDN VTSLGLRSLR
460 470 480 490 500
EVSAGRVYIT ENRRLCYLHT VQWAALSRRR ADLDIRNNKP RGKCQQEGKV
510 520 530 540 550
CDPLCSADGC WGPGPAQCLS CRHYSRRGVC VESCSFTQGE TREFAEGTEC
560 570 580 590 600
FECHPECERV EGGITCNGSG ADTCTRCAHY RDGPHCVERC PEGILGERGP
610 620 630 640 650
IYKYPDSSRE CRPCHENCTR GCTGPLLQDC LGDALPSARR APTVIAVLVV
660 670 680 690 700
GGLFLSCSCV LLSLLYWRGK KIQKKRAMRR YLERGESLEP LDPSEKANKV
710 720 730 740 750
LARIFKETEL KRLKVLGSGV FGTVHKGIWI PDGDSIKIPV SIKVIQDWSG
760 770 780 790 800
QQSFHAVTDH MLAIGSLDHA YIVRLLGICP GPQLQLVTQL LPLGSLLDYV
810 820 830 840 850
RKNRGSISPQ LLLNWCVQVA KGMYYLEEHR MVHRNLAARN VLLKSPSQAQ
860 870 880 890 900
VADFGIADLL YPDDKKYFYN EVKTPIKWMA LESIHFGKYT HQSDVWSYGV
910 920 930 940 950
TLWEMMTFGA EPYAGIRLPE VPDLLEKGER LPQPHICTID VYMVMVKCWM
960 970 980 990 1000
IDENIRPTFK ELANEFTRMA RDPPRYLVIK ESGAVPPAEP PTLSDKELDE
1010 1020 1030 1040 1050
METLELEEEE LDVSFGLCPP RPRGSCTRSP SLLSPPAGYI PMNQPGLGSR
1060 1070 1080 1090 1100
QGTGTRPPRR SRQESVGRTV SESSEGRGTA SELDLAEGLS LSGSLCRSLR
1110 1120 1130 1140 1150
SRGDSAYLSQ RESFPPPPPG SEGSEEDANG YVTPSCAGRE PGPTGGSVPE
1160 1170 1180 1190 1200
LEEEYEYMNR QPGAPLQAPP PRPASLEELG YEYMEVGSEL GSPAGPPQSR
1210 1220 1230 1240 1250
GEEEEDYEYM NKQPRLSRSL GNVVGGLGPR HESCPPRHDG YTDMRPGEPT
1260 1270 1280 1290 1300
PAPPEEQGYE EMEAVLAPRG PPCPGCRSPP GPPPTCMKPL RSLEASDCAF
1310
DNPDYWHSRL FAKVDAQRT
Length:1,319
Mass (Da):146,222
Last modified:March 7, 2006 - v1
Checksum:iD6E487257700A0B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ358720 mRNA. Translation: ABC88378.1.
RefSeqiNP_001038134.1. NM_001044669.1.
UniGeneiGga.33709.

Genome annotation databases

GeneIDi693245.
KEGGigga:693245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ358720 mRNA. Translation: ABC88378.1.
RefSeqiNP_001038134.1. NM_001044669.1.
UniGeneiGga.33709.

3D structure databases

ProteinModelPortaliQ2HZD7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi693245.
KEGGigga:693245.

Organism-specific databases

CTDi2065.

Phylogenomic databases

HOVERGENiHBG000490.
KOiK05084.
PhylomeDBiQ2HZD7.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR032778. GF_recep_IV.
IPR009030. Growth_fac_rcpt_.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR000719. Prot_kinase_dom.
IPR000494. Rcpt_L-dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF14843. GF_recep_IV. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ2HZD7_CHICK
AccessioniPrimary (citable) accession number: Q2HZD7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.