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Protein

Tryptophan 5-hydroxylase 2

Gene

TPH2

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.

Cofactori

Fe2+By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi318 – 3181IronBy similarity
Metal bindingi323 – 3231IronBy similarity
Metal bindingi363 – 3631IronBy similarity

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. tryptophan 5-monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. aromatic amino acid family metabolic process Source: InterPro
  2. serotonin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Serotonin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.16.4. 3126.
UniPathwayiUPA00846; UER00799.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan 5-hydroxylase 2 (EC:1.14.16.4)
Alternative name(s):
Tryptophan 5-monooxygenase 2
Gene namesi
Name:TPH2
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Tryptophan 5-hydroxylase 2PRO_0000252111Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000010151.

Structurei

3D structure databases

ProteinModelPortaliQ2HZ26.
SMRiQ2HZ26. Positions 151-484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 14076ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ACT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG3186.
HOGENOMiHOG000233373.
HOVERGENiHBG006841.
InParanoidiQ2HZ26.
KOiK00502.

Family and domain databases

Gene3Di1.10.800.10. 1 hit.
InterProiIPR002912. ACT_dom.
IPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005963. Trp_5_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
[Graphical view]
PANTHERiPTHR11473. PTHR11473. 1 hit.
PfamiPF00351. Biopterin_H. 1 hit.
[Graphical view]
PIRSFiPIRSF000336. TH. 1 hit.
PRINTSiPR00372. FYWHYDRXLASE.
SUPFAMiSSF56534. SSF56534. 1 hit.
TIGRFAMsiTIGR01270. Trp_5_monoox. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2HZ26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPAMMMFSS KYWARRGFSL DSAVPEEHQL LGNLTLNKAN SGKNDDKGNK
60 70 80 90 100
GSSKNETATE SGKTAVVFSL KNEVGGLVKA LRLFQEKRVH MVHIESRKSR
110 120 130 140 150
RRSSEVEIFV DCECGKTEFN ELIQLLKFQT TIVTLNPPEN IWTEEEELED
160 170 180 190 200
VPWFPRKISE LDKCSHRVLM YGSELDADHP GFKDNVYRQR RKYFVDVAMG
210 220 230 240 250
YKYGQPIPRV EYTEEETKTW GVVFRELSKL YPTHACREYL KNFPLLTKYC
260 270 280 290 300
GYREDNVPQL EDVSMFLKER SGFTVRPVAG YLSPRDFLAG LAYRVFHCTQ
310 320 330 340 350
YIRHGSDPLY TPEPDTCHEL LGHVPLLADP KFAQFSQEIG LASLGASDED
360 370 380 390 400
VQKLATCYFF TIEFGLCKQE GQLRAYGAGL LSSIGELKHA LSDKACVKAF
410 420 430 440 450
DPKTTCLQEC LITTFQEAYF VSESFEEAKE KMRDFAKSIT RPFSVYFNPY
460 470 480 490
TQSIEILKDT RSIENVVQDL RSDLNTVCDA LNKMNQYLGI
Length:490
Mass (Da):56,095
Last modified:March 7, 2006 - v1
Checksum:iDB6A60DD77B4D5AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ360113 mRNA. Translation: ABC94730.1.
RefSeqiNP_001035035.1. NM_001039946.1.
UniGeneiMmu.10250.

Genome annotation databases

GeneIDi664730.
KEGGimcc:664730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ360113 mRNA. Translation: ABC94730.1.
RefSeqiNP_001035035.1. NM_001039946.1.
UniGeneiMmu.10250.

3D structure databases

ProteinModelPortaliQ2HZ26.
SMRiQ2HZ26. Positions 151-484.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000010151.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi664730.
KEGGimcc:664730.

Organism-specific databases

CTDi121278.

Phylogenomic databases

eggNOGiCOG3186.
HOGENOMiHOG000233373.
HOVERGENiHBG006841.
InParanoidiQ2HZ26.
KOiK00502.

Enzyme and pathway databases

UniPathwayiUPA00846; UER00799.
BRENDAi1.14.16.4. 3126.

Miscellaneous databases

NextBioi19984361.

Family and domain databases

Gene3Di1.10.800.10. 1 hit.
InterProiIPR002912. ACT_dom.
IPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005963. Trp_5_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
[Graphical view]
PANTHERiPTHR11473. PTHR11473. 1 hit.
PfamiPF00351. Biopterin_H. 1 hit.
[Graphical view]
PIRSFiPIRSF000336. TH. 1 hit.
PRINTSiPR00372. FYWHYDRXLASE.
SUPFAMiSSF56534. SSF56534. 1 hit.
TIGRFAMsiTIGR01270. Trp_5_monoox. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Chen G.-L., Miller G.M.
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTPH2_MACMU
AccessioniPrimary (citable) accession number: Q2HZ26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 7, 2006
Last modified: April 1, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.