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Protein

Violacin-A

Gene
N/A
Organism
Viola odorata (Sweet violet)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably participates in a plant defense mechanism. Has low hemolytic activity.Curated1 Publication

Miscellaneous

The presence of a premature stop codon inhibits the translation of a key Asn residue that is thought to be required for cyclization.

GO - Biological processi

Keywordsi

Biological processCytolysis, Hemolysis, Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Violacin-A
Alternative name(s):
Violacin-1
OrganismiViola odorata (Sweet violet)
Taxonomic identifieri97441 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesViolaceaeViola

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000029496530 – 792 PublicationsAdd BLAST50
PeptideiPRO_000029496680 – 106Violacin-A1 PublicationAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi84 ↔ 981 Publication
Disulfide bondi88 ↔ 1001 Publication
Disulfide bondi93 ↔ 1051 Publication

Post-translational modificationi

Violacin-A is not a cyclic peptide.2 Publications

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FQANMR-A80-106[»]
ProteinModelPortaliQ2HY54.
SMRiQ2HY54.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ2HY54.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.1 Publication

Sequence similaritiesi

Belongs to the cyclotide family. Moebius subfamily.Sequence analysis

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR005535. Cyclotide.
PfamiView protein in Pfam
PF03784. Cyclotide. 1 hit.
SUPFAMiSSF57038. SSF57038. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2HY54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAQKMKMVI GLVLVATTAF ALMIPAASAV DDFITRRAYD NLVKSGAIKD
60 70 80 90 100
IPVMAKTIIS NPVLEEGMLT YYTNKKLGDS AISCGETCFK FKCYTPRCSC

SYPVCK
Length:106
Mass (Da):11,589
Last modified:March 7, 2006 - v1
Checksum:iA44C6D66F24B7115
GO

Mass spectrometryi

Molecular mass is 3004.9 Da from positions 80 - 106. Determined by MALDI. 1 Publication
Molecular mass is 3004.3 Da from positions 80 - 106. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ365813 mRNA. Translation: ABC94585.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ365813 mRNA. Translation: ABC94585.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FQANMR-A80-106[»]
ProteinModelPortaliQ2HY54.
SMRiQ2HY54.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ2HY54.

Family and domain databases

InterProiView protein in InterPro
IPR005535. Cyclotide.
PfamiView protein in Pfam
PF03784. Cyclotide. 1 hit.
SUPFAMiSSF57038. SSF57038. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVIOLA_VIOOD
AccessioniPrimary (citable) accession number: Q2HY54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 7, 2006
Last modified: March 15, 2017
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.