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Protein
Submitted name:

Protein tyrosine phosphatase receptor type D

Gene

PTPRD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation, ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase receptor type DImported
Gene namesi
Name:PTPRDImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1267 – 129024HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34013.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 19121892Sequence analysisPRO_5004209372Add
BLAST

Proteomic databases

PaxDbiQ2HXI4.
PRIDEiQ2HXI4.

Expressioni

Gene expression databases

GenevisibleiQ2HXI4. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348812.

Structurei

3D structure databases

ProteinModelPortaliQ2HXI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 11491Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini126 – 22499Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini236 – 31883Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini325 – 41591Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini420 – 51697Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini518 – 60790Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini612 – 70998Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini714 – 822109Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini823 – 91694Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini921 – 101696Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1020 – 110687Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1357 – 1612256Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini1532 – 160372TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST
Domaini1644 – 1903260Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini1821 – 189474TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
HOVERGENiHBG053758.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 2 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2HXI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD
60 70 80 90 100
PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA
110 120 130 140 150
SNNVGEISVS TRLTVLREDQ IPRGFPTIDM GPQLKVVERT RTATMLCAAS
160 170 180 190 200
GNPDPEITWF KDFLPVDTSN NNGRIKQLRS ESIGGTPIRG ALQIEQSEES
210 220 230 240 250
DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI PPTNHEIMPG
260 270 280 290 300
GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY
310 320 330 340 350
TCVAMSTLGV IEAIAQITVK PLPKPPGTPV VTESTATSIT LTWDSGNPEP
360 370 380 390 400
VSYYIIQHKP KNSEELYKEI DGVATTRYSV AGLSPYSDYE FRVVAVNNIG
410 420 430 440 450
RGPPSEPVLT QTSEQAPSSA PRDVQARMLS STTILVQWKE PEEPNGQIQG
460 470 480 490 500
YRVYYTMDPT QHVNNWMKHN VADSQITTIG NLVPQKTYSV KVLAFTSIGD
510 520 530 540 550
GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR SDTIANYELV
560 570 580 590 600
YKDGEHGEEQ RITIEPGTSY RLQGLKPNSL YYFRLAARSP QGLGASTAEI
610 620 630 640 650
SARTMQSKPS APPQDISCTS PSSTSILVSW QPPPVEKQNG IITEYSIKYT
660 670 680 690 700
AVDGEDDKPH EILGIPSDTT KYLLEQLEKW TEYRITVTAH TDVGPGPESL
710 720 730 740 750
SVLIRTNEDV PSGPPRKVEV EAVNSTSVKV SWRSPVPNKQ HGQIRGYQVH
760 770 780 790 800
YVRMENGEPK GQPMLKDVML ADAQWEFDDT TEHDMIISGL QPETSYSLTV
810 820 830 840 850
TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV INHTQMNTAL IQWHPPVDTF
860 870 880 890 900
GPLQGYRLKF GRKDMEPLTT LEFSEKEDHF TATDIHKGAS YVFRLSARNK
910 920 930 940 950
VGFGEEMVKE ISIPEEVPTG FPQNLHSEGT TSTSVQLSWQ PPVLAERNGI
960 970 980 990 1000
ITKYTLLYRD INIPLLPMEQ LIVPADTTMT LTGLKPDTTY DVKVRAHTSK
1010 1020 1030 1040 1050
GPGPYSPSVQ FRTLPVDQVF AKNFHVKAVM KTSVLLSWEI PENYNSAMPF
1060 1070 1080 1090 1100
KILYDDGKMV EEVDGRATQK LIVNLKPEKS YSFVLTNRGN SAGGLQHRVT
1110 1120 1130 1140 1150
AKTAPDVLRT KPAFIGKTNL DGMITVQLPE VPANENIKGY YIIIVPLKKS
1160 1170 1180 1190 1200
RGKFIKPWES PDEMELDELL KEISRKRRSI RYGREVELKP YIAAHFDVLP
1210 1220 1230 1240 1250
TEFTLGDDKH YGGFTNKQLQ SGQEYVFFVL AVMEHAESKM YATSPYSDPV
1260 1270 1280 1290 1300
VSMDLDPQPI TDEEEGLIWV VGPVLAVVFI ICIVIAILLY KRKRAESDSR
1310 1320 1330 1340 1350
KSSIPNNKEI PSHHPTDPVE LRRLNFQTPG MASHPPIPIL ELADHIERLK
1360 1370 1380 1390 1400
ANDNLKFSQE YESIDPGQQF TWEHSNLEVN KPKNRYANVI AYDHSRVLLS
1410 1420 1430 1440 1450
AIEGIPGSDY VNANYIDGYR KQNAYIATQG SLPETFGDFW RMIWEQRSAT
1460 1470 1480 1490 1500
VVMMTKLEER SRVKCDQYWP SRGTETHGLV QVTLLDTVEL ATYCVRTFAL
1510 1520 1530 1540 1550
YKNGSSEKRE VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT CNPPDAGPMV
1560 1570 1580 1590 1600
VHCSAGVGRT GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED
1610 1620 1630 1640 1650
QYIFIHDALL EAVTCGNTEV PARNLYAYIQ KLTQIETGEN VTGMELEFKR
1660 1670 1680 1690 1700
LASSKAHTSR FISANLPCNK FKNRLVNIMP YESTRVCLQP IRGVEGSDYI
1710 1720 1730 1740 1750
NASFIDGYRQ QKAYIATQGP LAETTEDFWR MLWEHNSTIV VMLTKLREMG
1760 1770 1780 1790 1800
REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV
1810 1820 1830 1840 1850
RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI SVHCSAGVGR
1860 1870 1880 1890 1900
TGVFITLSIV LERMRYEGVV DIFQTVKMLR TQRPAMVQTE DQYQFSYRAA
1910
LEYLGSFDHY AT
Length:1,912
Mass (Da):214,786
Last modified:March 21, 2006 - v1
Checksum:i0889DDDA9AD62D2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB211400 mRNA. Translation: BAE79816.1.
RefSeqiNP_002830.1. NM_002839.3.
UniGeneiHs.446083.

Genome annotation databases

GeneIDi5789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB211400 mRNA. Translation: BAE79816.1.
RefSeqiNP_002830.1. NM_002839.3.
UniGeneiHs.446083.

3D structure databases

ProteinModelPortaliQ2HXI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348812.

Proteomic databases

PaxDbiQ2HXI4.
PRIDEiQ2HXI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5789.

Organism-specific databases

CTDi5789.
PharmGKBiPA34013.

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
HOVERGENiHBG053758.

Miscellaneous databases

ChiTaRSiPTPRD. human.
GenomeRNAii5789.

Gene expression databases

GenevisibleiQ2HXI4. HS.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 2 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of Chromosome Arm 9p as the Most Frequent Target of Homozygous Deletions in Lung Cancer."
    Sato M., Kohno T., Yokota J.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ2HXI4_HUMAN
AccessioniPrimary (citable) accession number: Q2HXI4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.