Reviewed, UniProtKB/Swiss-Prot Q2HVD6 (MTA70_MEDTR)

Names and origin

Protein names

Recommended name:
    Putative N6-adenosine-methyltransferase MT-A70-like
    EC=2.1.1.62

Gene names

ORF Names:

MtrDRAFT_AC148918g15v1

Organism

Medicago truncatula (Barrel medic)

Taxonomic identifier

3880 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Fabales › Fabaceae › Papilionoideae › Trifolieae › Medicago

Protein attributes

Sequence length	614 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Putative N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation By similarity.
Catalytic activity	S-adenosyl-L-methionine + m7G(5')pppAm = S-adenosyl-L-homocysteine + m7G(5')pppm6Am.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the MT-A70-like family.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 614	614	Putative N6-adenosine-methyltransferase MT-A70-like		PRO_0000260071
Regions
	Compositional bias	206 – 213	8	Poly-Gln
	Compositional bias	362 – 365	4	Poly-Pro

Sequences

	Sequence		Length	Mass (Da)
	Q2HVD6-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 6D23498646697FAA	FASTA	614	69,286
	10 20 30 40 50 60 MEMETDEGIN SLKARIETQH KSHMYMLSSV QSVIPNFVSS LDLSLKVLSS FNHRPFAPTP 70 80 90 100 110 120 PLTNFNPPKS SSLQQLPQKP SVKTLKTSLV VTTNPVLEKV TPLSVVLSMV AVCLLSRLPF 130 140 150 160 170 180 MEIDSSTLWR KLENDETFTP QDKAAFQELA GDSGGPTLAV EIALRSMADD NGAVELEEFA 190 200 210 220 230 240 VSGKSRIMVL NIDRTRLLRQ LPETAQHQLQ QQQDELSLGD GNMNQNQQQI AKCSMNLEDV 250 260 270 280 290 300 DALINKKSFR EMQKYETAKE LLKIIQTPSI REAAVAAKFK TKGGSQMRPY CDLPTKEDCR 310 320 330 340 350 360 RRTGSFIACN KLHFRRIIAL HTDINLGDCP FLRTCRHMNT CKYVHYEEDP TPDLPPTMMC 370 380 390 400 410 420 APPPPLKPLK QQRAEYCSEA ELGQPQWINC DIRNFRMDIL GKFGVIMADP PWDIHMELPY 430 440 450 460 470 480 GTMADDEMRT LNVPALQTHG LIFLWVTGRA MELGRECLER WGYKCVEEII WVKTNQLQRI 490 500 510 520 530 540 IRTGRTGHWL NHSKEHCLVG IKGSPEVNRN IDTNVIVSEV RETSRKPDEM YAMMERISPG 550 560 570 580 590 600 TRKVELFARM HNTHAGWMSL GNQLSGVRLV DEGLRARFKA AYPDVEVQPA SPSRASAMEL 610 DSSVAAQTTT SAMM

References

[1]	The International Medicago Genome Annotation Group Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC148918 Genomic DNA. Translation: ABD28511.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.1.1.62. 266820.
Family and domain databases
InterPro	IPR007757. MT-A70. [Graphical view]
Pfam	PF05063. MT-A70. 1 hit. [Graphical view]
PROSITE	PS51143. MT_A70. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTA70_MEDTR

Accession

Primary (citable) accession number: Q2HVD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	March 21, 2006
Last modified:	June 16, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)