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Protein

Putative N6-adenosine-methyltransferase MT-A70-like

Gene

MtrDRAFT_AC148918g15v1

Organism
Medicago truncatula (Barrel medic) (Medicago tribuloides)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Putative N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + m7G(5')pppAm = S-adenosyl-L-homocysteine + m7G(5')pppm6Am.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei409S-adenosyl-L-methionineBy similarity1
Binding sitei526S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Putative N6-adenosine-methyltransferase MT-A70-like (EC:2.1.1.62By similarity)
Gene namesi
ORF Names:MtrDRAFT_AC148918g15v1
OrganismiMedicago truncatula (Barrel medic) (Medicago tribuloides)
Taxonomic identifieri3880 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002600711 – 614Putative N6-adenosine-methyltransferase MT-A70-likeAdd BLAST614

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni391 – 392S-adenosyl-L-methionine bindingBy similarity2
Regioni479 – 492Positively charged region required for RNA-bindingBy similarityAdd BLAST14
Regioni549 – 552S-adenosyl-L-methionine bindingBy similarity4
Regioni562 – 563S-adenosyl-L-methionine bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi206 – 213Poly-Gln8
Compositional biasi362 – 365Poly-Pro4

Sequence similaritiesi

Belongs to the MT-A70-like family.PROSITE-ProRule annotation

Phylogenomic databases

KOiK05925.
OMAiMETENEP.
OrthoDBiEOG093603WZ.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF05063. MT-A70. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51143. MT_A70. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2HVD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMETDEGIN SLKARIETQH KSHMYMLSSV QSVIPNFVSS LDLSLKVLSS
60 70 80 90 100
FNHRPFAPTP PLTNFNPPKS SSLQQLPQKP SVKTLKTSLV VTTNPVLEKV
110 120 130 140 150
TPLSVVLSMV AVCLLSRLPF MEIDSSTLWR KLENDETFTP QDKAAFQELA
160 170 180 190 200
GDSGGPTLAV EIALRSMADD NGAVELEEFA VSGKSRIMVL NIDRTRLLRQ
210 220 230 240 250
LPETAQHQLQ QQQDELSLGD GNMNQNQQQI AKCSMNLEDV DALINKKSFR
260 270 280 290 300
EMQKYETAKE LLKIIQTPSI REAAVAAKFK TKGGSQMRPY CDLPTKEDCR
310 320 330 340 350
RRTGSFIACN KLHFRRIIAL HTDINLGDCP FLRTCRHMNT CKYVHYEEDP
360 370 380 390 400
TPDLPPTMMC APPPPLKPLK QQRAEYCSEA ELGQPQWINC DIRNFRMDIL
410 420 430 440 450
GKFGVIMADP PWDIHMELPY GTMADDEMRT LNVPALQTHG LIFLWVTGRA
460 470 480 490 500
MELGRECLER WGYKCVEEII WVKTNQLQRI IRTGRTGHWL NHSKEHCLVG
510 520 530 540 550
IKGSPEVNRN IDTNVIVSEV RETSRKPDEM YAMMERISPG TRKVELFARM
560 570 580 590 600
HNTHAGWMSL GNQLSGVRLV DEGLRARFKA AYPDVEVQPA SPSRASAMEL
610
DSSVAAQTTT SAMM
Length:614
Mass (Da):69,286
Last modified:March 21, 2006 - v1
Checksum:i6D23498646697FAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC148918 Genomic DNA. Translation: ABD28511.1.
RefSeqiXP_003597586.1. XM_003597538.1.

Genome annotation databases

EnsemblPlantsiAES67837; AES67837; MTR_2g099870.
GeneIDi11429893.
GrameneiAES67837; AES67837; MTR_2g099870.
KEGGimtr:MTR_2g099870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC148918 Genomic DNA. Translation: ABD28511.1.
RefSeqiXP_003597586.1. XM_003597538.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAES67837; AES67837; MTR_2g099870.
GeneIDi11429893.
GrameneiAES67837; AES67837; MTR_2g099870.
KEGGimtr:MTR_2g099870.

Phylogenomic databases

KOiK05925.
OMAiMETENEP.
OrthoDBiEOG093603WZ.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF05063. MT-A70. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51143. MT_A70. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTA70_MEDTR
AccessioniPrimary (citable) accession number: Q2HVD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 21, 2006
Last modified: November 30, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.