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Q2HVD6

- MTA70_MEDTR

UniProt

Q2HVD6 - MTA70_MEDTR

Protein

Putative N6-adenosine-methyltransferase MT-A70-like

Gene

MtrDRAFT_AC148918g15v1

Organism
Medicago truncatula (Barrel medic) (Medicago tribuloides)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Putative N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + m7G(5')pppAm = S-adenosyl-L-homocysteine + m7G(5')pppm6Am.

    GO - Molecular functioni

    1. mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Source: UniProtKB-EC
    2. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative N6-adenosine-methyltransferase MT-A70-like (EC:2.1.1.62)
    Gene namesi
    ORF Names:MtrDRAFT_AC148918g15v1
    OrganismiMedicago truncatula (Barrel medic) (Medicago tribuloides)
    Taxonomic identifieri3880 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 614614Putative N6-adenosine-methyltransferase MT-A70-likePRO_0000260071Add
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi206 – 2138Poly-Gln
    Compositional biasi362 – 3654Poly-Pro

    Sequence similaritiesi

    Belongs to the MT-A70-like family.PROSITE-ProRule annotation

    Phylogenomic databases

    KOiK05925.
    OMAiARIHNTH.

    Family and domain databases

    InterProiIPR007757. MT-A70-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF05063. MT-A70. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51143. MT_A70. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2HVD6-1 [UniParc]FASTAAdd to Basket

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    MEMETDEGIN SLKARIETQH KSHMYMLSSV QSVIPNFVSS LDLSLKVLSS    50
    FNHRPFAPTP PLTNFNPPKS SSLQQLPQKP SVKTLKTSLV VTTNPVLEKV 100
    TPLSVVLSMV AVCLLSRLPF MEIDSSTLWR KLENDETFTP QDKAAFQELA 150
    GDSGGPTLAV EIALRSMADD NGAVELEEFA VSGKSRIMVL NIDRTRLLRQ 200
    LPETAQHQLQ QQQDELSLGD GNMNQNQQQI AKCSMNLEDV DALINKKSFR 250
    EMQKYETAKE LLKIIQTPSI REAAVAAKFK TKGGSQMRPY CDLPTKEDCR 300
    RRTGSFIACN KLHFRRIIAL HTDINLGDCP FLRTCRHMNT CKYVHYEEDP 350
    TPDLPPTMMC APPPPLKPLK QQRAEYCSEA ELGQPQWINC DIRNFRMDIL 400
    GKFGVIMADP PWDIHMELPY GTMADDEMRT LNVPALQTHG LIFLWVTGRA 450
    MELGRECLER WGYKCVEEII WVKTNQLQRI IRTGRTGHWL NHSKEHCLVG 500
    IKGSPEVNRN IDTNVIVSEV RETSRKPDEM YAMMERISPG TRKVELFARM 550
    HNTHAGWMSL GNQLSGVRLV DEGLRARFKA AYPDVEVQPA SPSRASAMEL 600
    DSSVAAQTTT SAMM 614
    Length:614
    Mass (Da):69,286
    Last modified:March 21, 2006 - v1
    Checksum:i6D23498646697FAA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC148918 Genomic DNA. Translation: ABD28511.1.
    RefSeqiXP_003597586.1. XM_003597538.1.

    Genome annotation databases

    GeneIDi11429893.
    KEGGimtr:MTR_2g099870.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC148918 Genomic DNA. Translation: ABD28511.1 .
    RefSeqi XP_003597586.1. XM_003597538.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11429893.
    KEGGi mtr:MTR_2g099870.

    Phylogenomic databases

    KOi K05925.
    OMAi ARIHNTH.

    Family and domain databases

    InterProi IPR007757. MT-A70-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF05063. MT-A70. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51143. MT_A70. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The International Medicago Genome Annotation Group
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiMTA70_MEDTR
    AccessioniPrimary (citable) accession number: Q2HVD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3