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Protein

Protein K1

Gene

K1

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Promotes host cell survival pathways and may contribute to pathogenesis by preventing infected cells from undergoing apoptosis. Acts in host B-cells by mimicking the activated B-cell receptor complex. The cytoplasmic tail of K1 can induce the phosphorylation of a number of different kinases, leading to the activation of survival signaling pathways.3 Publications

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Modulation of host cell apoptosis by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Protein K1
Gene namesi
Name:K1
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 220ExtracellularSequence analysisAdd BLAST202
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Topological domaini242 – 279CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000042377619 – 279Protein K1Add BLAST261

Interactioni

Subunit structurei

Homooligomer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ2HRD5.
SMRiQ2HRD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK21669.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR021022. HHSV-8_K1.
IPR013783. Ig-like_fold.
IPR004121. K1_C.
PfamiView protein in Pfam
PF02960. K1. 1 hit.
PF11049. KSHV_K1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2HRD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLYVVCSLA VCFRGLLSLS LQSSPNLCPG VISTPYTLTC PSNTSLPTSW
60 70 80 90 100
YCNDTRLLRV TQGTLTVDTL ICNFSCVGQS GHRYSLWITW YAQPVLQTFC
110 120 130 140 150
GQPSNTVTCG QHVTLYCSTS GNNVTVWHLP NGQNETVSQT KYYNFTLMNQ
160 170 180 190 200
TEGCYACSNG LSSRLSNRLC FSARCANITP ETHTVSVSST TGFRTFATAP
210 220 230 240 250
TLFVMKEVKS TYLYIQEHLL VFMTLVALIG TMCGILGTII FAHCQKQRDS
260 270
NKTVPQQLQD YYSLHDLCTE DYTQPVDWY
Length:279
Mass (Da):31,162
Last modified:May 15, 2007 - v1
Checksum:i2AF4EF505D1F3BD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28852.1.
RefSeqiYP_001129350.1. NC_009333.1.

Genome annotation databases

GeneIDi4961511.
KEGGivg:4961511.

Similar proteinsi

Entry informationi

Entry nameiK1_HHV8P
AccessioniPrimary (citable) accession number: Q2HRD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: May 15, 2007
Last modified: September 27, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome