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Protein

Viral interleukin-6 homolog

Gene

K2

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Initiates signal transduction through binding to interleukin-6 receptor subunit beta IL6ST, independently of the cognate IL6 receptor IL6R. In infected primary effusion lymphoma cells, promotes proliferation of cells, protects them from apoptosis, and promotes immune evasion of interferon activity. Drives also blood to lymphatic endothelial cell differentiation.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processEvasion of host immunity by viral interleukin-like protein, Host-virus interaction, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Viral interleukin-6 homolog
Short name:
vIL-6
Gene namesi
Name:K2
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000042384323 – 204Viral interleukin-6 homologAdd BLAST182

Interactioni

Subunit structurei

Interacts with host IL6ST.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ2HRC7. 2 interactors.

Structurei

3D structure databases

SMRiQ2HRC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK21670.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
PfamiView protein in Pfam
PF00489. IL6. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiView protein in SMART
SM00126. IL6. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2HRC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWFKLWSIL LVGSLLVSGT RGKLPDAPEF EKDLLIQRLN WMLWVIDECF
60 70 80 90 100
RDLCYRTGIC KGILEPAAIF HLKLPAINDT DHCGLIGFNE TSCLKKLADG
110 120 130 140 150
FFEFEVLFKF LTTEFGKSVI NVDVMELLTK TLGWDIQEEL NKLTKTHYSP
160 170 180 190 200
PKFDRGLLGR LQGLKYWVRH FASFYVLSAM EKFAGQAVRV LNSIPDVTPD

VHDK
Length:204
Mass (Da):23,460
Last modified:March 21, 2006 - v1
Checksum:i722A16644C6835A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28856.1.
RefSeqiYP_001129358.1. NC_009333.1.

Genome annotation databases

GeneIDi4961449.
KEGGivg:4961449.

Similar proteinsi

Entry informationi

Entry nameiVIL6_HHV8P
AccessioniPrimary (citable) accession number: Q2HRC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: March 21, 2006
Last modified: October 25, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families