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Protein

Putative Dihydrofolate reductase

Gene

ORF2

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Putative Dihydrofolate reductase (EC:1.5.1.3)
Gene namesi
Name:ORF2
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004238101 – 210Putative Dihydrofolate reductaseAdd BLAST210

Structurei

3D structure databases

SMRiQ2HRC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 184DHFRPROSITE-ProRule annotationAdd BLAST181

Sequence similaritiesi

Belongs to the dihydrofolate reductase family.Curated

Phylogenomic databases

OrthoDBiVOG090001MI.

Family and domain databases

CDDicd00209. DHFR. 1 hit.
Gene3Di3.40.430.10. 1 hit.
InterProiView protein in InterPro
IPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
PfamiView protein in Pfam
PF00186. DHFR_1. 1 hit.
PRINTSiPR00070. DHFR.
SUPFAMiSSF53597. SSF53597. 1 hit.
PROSITEiView protein in PROSITE
PS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2HRC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPTLYCVVA VDTKLGIGKN RCLPWPALRG DMRRFRQLTT DCAPGKQNMV
60 70 80 90 100
VMGRRTWLSI PAGCRPLAGR INVVLSRTLE TPPPGAHFLA SSLDAALGLA
110 120 130 140 150
RSPELAQQID KVWVIGGGNL YREALTGPWP VRLFLTRVLH DFACDVFLSH
160 170 180 190 200
DSLAAYARVN PKPGEQERVF QERGIFYMFE TYIKVTQSSD TALPDLERPR
210
PATPPFSETS
Length:210
Mass (Da):23,354
Last modified:March 21, 2006 - v1
Checksum:i1F7EC5D5D82690D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28857.1.
RefSeqiYP_001129359.1. NC_009333.1.

Genome annotation databases

GeneIDi4961454.
KEGGivg:4961454.

Similar proteinsi

Entry informationi

Entry nameiDYR_HHV8P
AccessioniPrimary (citable) accession number: Q2HRC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: March 21, 2006
Last modified: September 27, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families