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Q2HRC6 (DYR_HHV8P) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative Dihydrofolate reductase

EC=1.5.1.3
Gene names
Name:ORF2
OrganismHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) [Reference proteome]
Taxonomic identifier868565 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Sequence similarities

Belongs to the dihydrofolate reductase family.

Contains 1 DHFR (dihydrofolate reductase) domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Putative Dihydrofolate reductase
PRO_0000423810

Regions

Domain4 – 184181DHFR

Sequences

Sequence LengthMass (Da)Tools
Q2HRC6 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 1F7EC5D5D82690D2

FASTA21023,354
        10         20         30         40         50         60 
MDPTLYCVVA VDTKLGIGKN RCLPWPALRG DMRRFRQLTT DCAPGKQNMV VMGRRTWLSI 

        70         80         90        100        110        120 
PAGCRPLAGR INVVLSRTLE TPPPGAHFLA SSLDAALGLA RSPELAQQID KVWVIGGGNL 

       130        140        150        160        170        180 
YREALTGPWP VRLFLTRVLH DFACDVFLSH DSLAAYARVN PKPGEQERVF QERGIFYMFE 

       190        200        210 
TYIKVTQSSD TALPDLERPR PATPPFSETS 

« Hide

References

[1]"Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus."
Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.
J. Virol. 73:6953-6963(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Kaposi's sarcoma-associated herpesvirus immune modulation: an overview."
Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.
J. Gen. Virol. 87:1781-1804(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF148805 Genomic DNA. Translation: ABD28857.1.
RefSeqYP_001129359.1. NC_009333.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4961454.

Family and domain databases

Gene3D3.40.430.10. 1 hit.
InterProIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSPR00070. DHFR.
SUPFAMSSF53597. SSF53597. 1 hit.
PROSITEPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDYR_HHV8P
AccessionPrimary (citable) accession number: Q2HRC6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: March 21, 2006
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families