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Protein

Capsid vertex component 2

Gene

CVC2

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP.UniRule annotation

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral genome packaging, Viral penetration into host nucleus, Virus entry into host cell, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid vertex component 2UniRule annotation
Gene namesi
Name:CVC2UniRule annotation
Ordered Locus Names:ORF19
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004238061 – 549Capsid vertex component 2Add BLAST549

Interactioni

Subunit structurei

Heterodimerizes with CVC1. Interacts with major capsid protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices. Interacts with the large tegument protein/LTP.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 54Interaction with major capsid protein/MCPUniRule annotationAdd BLAST54

Sequence similaritiesi

Belongs to the herpesviridae CVC2 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900005N.

Family and domain databases

HAMAPiMF_04025. HSV_CVC2. 1 hit.
InterProiView protein in InterPro
IPR002493. Herpes_UL25.
PfamiView protein in Pfam
PF01499. Herpes_UL25. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2HRB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTSERSYLR YPKNRRWTEA GRFWAPHPEN VLFIHKPTME ETRRVALGLR
60 70 80 90 100
SQLVRNRERK TKAHLLSLEL DRLVQVHDSR VRVINADIDA VKQMIGNMTW
110 120 130 140 150
SDNIDMPQSR SHEPPLVTSP PQASHRNFTV AIVPGDPHFS VDRDLRGELM
160 170 180 190 200
PTLYMNQNQW LPSFGPWFIS LTDNAMQRRV FPKELKGTVN FQNSTSLKLI
210 220 230 240 250
SHTLTTVAST TADFFADARH LTDTQAALCL VNAYFCQKTS RQLPATPDDL
260 270 280 290 300
LADLPQKLDL LITQLKQESG PGDFSFTYSN PQERASLAPL NKESRYPTAF
310 320 330 340 350
FQRHKLHAMM AKAGLFPHNK GTGAPGTAPA MDLVFAITSA MFGSDIPPFS
360 370 380 390 400
AYQWNLRAGI VALEVFILAY GLLEFGQVAR GHPNRRLNLV SLLGPKFQPG
410 420 430 440 450
ALPDPNAPML KRGQLFSFIS EHYIIPTLQA NPNAPVSFIF PGIILAALEA
460 470 480 490 500
RSTVSHKQPG PFVNLTGSRF NEIFEILNQQ LTFRDPLALL QARTALRLAT
510 520 530 540
EEGLDVLLSH PSPPTLLQEI IKSQFGGGDD YDRAYFMVLG CLPVVLAVV
Length:549
Mass (Da):61,424
Last modified:May 15, 2007 - v1
Checksum:iE7A64C2EAE5A7D12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28870.1.
RefSeqiYP_001129372.1. NC_009333.1.

Genome annotation databases

GeneIDi4961508.
KEGGivg:4961508.

Similar proteinsi

Entry informationi

Entry nameiCVC2_HHV8P
AccessioniPrimary (citable) accession number: Q2HRB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: May 15, 2007
Last modified: June 7, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families