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Protein

Major capsid protein

Gene

MCP

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation1 Publication

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid proteinUniRule annotation
Short name:
MCPUniRule annotation
Gene namesi
Name:MCPUniRule annotation
Synonyms:ORF25
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=16 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004237601 – 1376Major capsid proteinAdd BLAST1376

Interactioni

Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2. Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus. Interacts with capsid vertex component 2/CVC2. Interacts with the small capsomere-interacting protein/SCP.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2HRA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae major capsid protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900000D.

Family and domain databases

HAMAPiMF_04016. HSV_MCP. 1 hit.
InterProiView protein in InterPro
IPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper_sf.
PfamiView protein in Pfam
PF03122. Herpes_MCP. 1 hit.
PRINTSiPR00235. HSVCAPSIDMCP.
SUPFAMiSSF103417. SSF103417. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2HRA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEATLEQRPF PYLATEANLL TQIKESAADG LFKSFQLLLG KDAREGSVRF
60 70 80 90 100
EALLGVYTNV VEFVKFLETA LAAACVNTEF KDLRRMIDGK IQFKISMPTI
110 120 130 140 150
AHGDGRRPNK QRQYIVMKAC NKHHIGAEIE LAAADIELLF AEKETPLDFT
160 170 180 190 200
EYAGAIKTIT SALQFGMDAL ERGLVDTVLA VKLRHAPPVF ILKTLGDPVY
210 220 230 240 250
SERGLKKAVK SDMVSMFKAH LIEHSFFLDK AELMTRGKQY VLTMLSDMLA
260 270 280 290 300
AVCEDTVFKG VSTYTTASGQ QVAGVLETTD SVMRRLMNLL GQVESAMSGP
310 320 330 340 350
AAYASYVVRG ANLVTAVSYG RAMRNFEQFM ARIVDHPNAL PSVEGDKAAL
360 370 380 390 400
ADGHDEIQRT RIAASLVKIG DKFVAIESLQ RMYNETQFPC PLNRRIQYTY
410 420 430 440 450
FFPVGLHLPV PRYSTSVSVR GVESPAIQST ETWVVNKNNV PLCFGYQNAL
460 470 480 490 500
KSICHPRMHN PTQSAQALNQ AFPDPDGGHG YGLRYEQTPN MNLFRTFHQY
510 520 530 540 550
YMGKNVAFVP DVAQKALVTT EDLLHPTSHR LLRLEVHPFF DFFVHPCPGA
560 570 580 590 600
RGSYRATHRT MVGNIPQPLA PREFQESRGA QFDAVTNMTH VIDQLTIDVI
610 620 630 640 650
QETAFDPAYP LFCYVIEAMI HGQEEKFVMN MPLIALVIQT YWVNSGKLAF
660 670 680 690 700
VNSYHMVRFI CTHMGNGSIP KEAHGHYRKI LGELIALEQA LLKLAGHETV
710 720 730 740 750
GRTPITHLVS ALLDPHLLPP FAYHDVFTDL MQKSSRQPII KIGDQNYDNP
760 770 780 790 800
QNRATFINLR GRMEDLVNNL VNIYQTRVNE DHDERHVLDV APLDENDYNP
810 820 830 840 850
VLEKLFYYVL MPVCSNGHMC GMGVDYQNVA LTLTYNGPVF ADVVNAQDDI
860 870 880 890 900
LLHLENGTLK DILQAGDIRP TVDMIRVLCT SFLTCPFVTQ AARVITKRDP
910 920 930 940 950
AQSFATHEYG KDVAQTVLVN GFGAFAVADR SREAAETMFY PVPFNKLYAD
960 970 980 990 1000
PLVAATLHPL LANYVTRLPN QRNAVVFNVP SNLMAEYEEW HKSPVAAYAA
1010 1020 1030 1040 1050
SCQATPGAIS AMVSMHQKLS APSFICQAKH RMHPGFAMTV VRTDEVLAEH
1060 1070 1080 1090 1100
ILYCSRASTS MFVGLPSVVR REVRSDAVTF EITHEIASLH TALGYSSVIA
1110 1120 1130 1140 1150
PAHVAAITTD MGVHCQDLFM IFPGDAYQDR QLHDYIKMKA GVQTGSPGNR
1160 1170 1180 1190 1200
MDHVGYTAGV PRCENLPGLS HGQLATCEII PTPVTSDVAY FQTPSNPRGR
1210 1220 1230 1240 1250
AACVVSCDAY SNESAERLLY DHSIPDPAYE CRSTNNPWAS QRGSLGDVLY
1260 1270 1280 1290 1300
NITFRQTALP GMYSPCRQFF HKEDIMRYNR GLYTLVNEYS ARLAGAPATS
1310 1320 1330 1340 1350
TTDLQYVVVN GTDVFLDQPC HMLQEAYPTL AASHRVMLDE YMSNKQTHAP
1360 1370
VHMGQYLIEE VAPMKRLLKL GNKVVY
Length:1,376
Mass (Da):153,420
Last modified:May 15, 2007 - v1
Checksum:i413E0CD4A7BB98D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28876.1.
RefSeqiYP_001129378.1. NC_009333.1.

Genome annotation databases

GeneIDi4961452.
KEGGivg:4961452.

Similar proteinsi

Entry informationi

Entry nameiMCP_HHV8P
AccessioniPrimary (citable) accession number: Q2HRA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: May 15, 2007
Last modified: November 22, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families