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Protein

Viral IRF4-like protein

Gene

vIRF-4

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in host cell apoptosis modulation by promoting TP53/p53 ubiquitination and subsequent degradation and thus downregulating TP53/p53-mediated apoptosis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi7 – 114IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST108

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processHost-virus interaction, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Viral IRF4-like protein
Short name:
vIRF-4
Gene namesi
Name:vIRF-4
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004237751 – 911Viral IRF4-like proteinAdd BLAST911

Interactioni

Subunit structurei

Interacts with host MDM2; this interaction facilitates the proteasomal degradation of TP53/p53.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MDM2Q009872EBI-9001898,EBI-389668From Homo sapiens.

Protein-protein interaction databases

IntActiQ2HR73. 1 interactor.

Structurei

Secondary structure

1911
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni207 – 210Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XXNX-ray1.60B202-216[»]
SMRiQ2HR73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi235 – 490Pro-richAdd BLAST256

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR001346. Interferon_reg_fact_DNA-bd_dom.
PROSITEiView protein in PROSITE
PS51507. IRF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2HR73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKAGGSEWA TLWIIDALEN NKFPYFSWFD RNNLLFAAPA PLPAGSDIPP
60 70 80 90 100
GWYSVYHAFD EECDRVYGPS PVVGQTVYGR FGRLLRGTRR AVVRNDLRYS
110 120 130 140 150
DTFGGSYVVW QLVRTPFKNC TYCYGAAYGP EKLQRFIQCL LSPPMQTTAT
160 170 180 190 200
RRSDTREQSY EEAGAAAPAP PKAPSGLRGR PRKSNRYYNV GDITTEQKAA
210 220 230 240 250
CSVWIPVNEG ASTSGMGSSG TRQVTQASSF TWRVPGDPPA PSTLTGPSDP
260 270 280 290 300
HSSGAGLPGT APPKPQHETR LAGTVSGVSG VAQTPGDTGQ LAPPMRDGSR
310 320 330 340 350
LPSTSPWIPA CFPWGDLPVT GWWPQGASGL PEKVHPPTTG QFDPLSPRWT
360 370 380 390 400
YTGIPSSQLN PAAPSWIPPH AQAGTFVGEF SQGAPLAPQG LLPQSGQCAS
410 420 430 440 450
AWLPRRETGA EGACGASTEG RAPQGAASER VYPFEPQPPS APAPGYAKPS
460 470 480 490 500
CYNWSPLAEP PATRPIRAPV WHPPVGHAVV PEVRTPLWIP WSSGGAPNQG
510 520 530 540 550
LSHTQGGASA TPSAGAPPTP EVAERQEPSS SGIPYVCQGD NMATGYRRVT
560 570 580 590 600
TSSGALEVEI IDLTGDSDTP STTVASTPLP VSGPRVFQPT VLYSAPEPAV
610 620 630 640 650
NPEVSHLPTE LERRECVCPG SGERPRVPLV STYAGDRYAV GGYGPEQSLV
660 670 680 690 700
PPPLGLPLTL SNLQGEDICT WEEGLGNILS ELQEEPSSST RQATDRRRPR
710 720 730 740 750
SRSPHGRRTP VSHSGPEKPP SKMFFDPPDS QRVSFVVEIF VYGNLRGTLR
760 770 780 790 800
REGDAGEAML CSWPVGDTLG HLCQSFVPEL LRIPRLTVPS PEQMEILNRV
810 820 830 840 850
FEGLGHGFPI FCSMSGIYSR NATQVEGWWF GNPNSRYERI LRSFSPRVPQ
860 870 880 890 900
QLFNTARYLA TTAAIPQTPL SVNPVTCGTV FFGASPASTE NFQNVPLTVK
910
IFIGSIWDSL H
Length:911
Mass (Da):97,956
Last modified:March 21, 2006 - v1
Checksum:i0F82DA473774DC2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28910.1.
RefSeqiYP_001129412.1. NC_009333.1.

Genome annotation databases

GeneIDi4961495.
KEGGivg:4961495.

Similar proteinsi

Entry informationi

Entry nameiVIRF4_HHV8P
AccessioniPrimary (citable) accession number: Q2HR73
Secondary accession number(s): D0UZS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: March 21, 2006
Last modified: February 15, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families