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Protein

Viral IRF2-like protein

Gene

vIRF-2

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the inhibition of host immune response. Acts by interacting with host EIF2AK2/PKR and inhibiting its activation. In turn, EIF2AK2/PKR substrates including EIF2S1 or histone H2A are not phosphorylated.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi7 – 103IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST97

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host PKR by virus, Transcription, Transcription regulation, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Viral IRF2-like protein
Short name:
vIRF-2
Gene namesi
Name:vIRF-2
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

Q2HR71:
  • Host nucleus 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004237741 – 680Viral IRF2-like proteinAdd BLAST680

Interactioni

Subunit structurei

Interacts with host EIF2AK2/PKR.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF2AK2P195252EBI-8876177,EBI-640775From Homo sapiens.

Protein-protein interaction databases

BioGridi1776994. 1 interactor.
IntActiQ2HR71. 1 interactor.

Structurei

Secondary structure

1680
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 20Combined sources13
Beta strandi28 – 30Combined sources3
Turni31 – 34Combined sources4
Beta strandi35 – 39Combined sources5
Beta strandi41 – 43Combined sources3
Helixi54 – 64Combined sources11
Helixi76 – 86Combined sources11
Beta strandi89 – 91Combined sources3
Beta strandi96 – 100Combined sources5
Beta strandi103 – 110Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P55X-ray2.50A/B7-114[»]
SMRiQ2HR71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

KOiK21654.

Family and domain databases

CDDicd00103. IRF. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS51507. IRF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2HR71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRYTESEWL TDFIIDALDS GRFWGVGWLD EQKRIFTVPG RNRRERMPEG
60 70 80 90 100
FDDFYEAFLE ERRRHGLPEI PETETGLGCF GRLLRTANRA RQERPFTIYK
110 120 130 140 150
GKMKLNRWIM TPRPYKGCEG CLVYLTQEPA MKNMLKALFG IYPHDDKHRE
160 170 180 190 200
KALRRSLRKK AQREAARKQA AAVATPTTSS AAEVSSRSQS EDTESSDSEN
210 220 230 240 250
ELWVGAQGFV GRDMHSLFFE EPEPSGFGSS GQSSSLLAPD SPRPSTSQVQ
260 270 280 290 300
GPLHVHTPTD LCLPTGGLPS PVIFPHETQG LLAPPAGQSQ TPFSPEGPVP
310 320 330 340 350
SHVSGLDDCL PMVDHIEGCL LDLLSDVGQE LPDLGDLGEL LCETASPQGP
360 370 380 390 400
MQSEGGEEGS TESVSVLPAT HPLESSAPGA SVMGSGQELP DLGDLSELLC
410 420 430 440 450
ETASPQGPMQ SEGGEEGSTE SVSVLPATHP LESSAPGASV MGSSFQASDN
460 470 480 490 500
VDDFIDCIPP LCRDDRDVED QEKADQTFYW YGSDMRPKVL TATQSVAAYL
510 520 530 540 550
SKKQAIYKVG DKLVPLVVEV YYFGEKVKTH FDLTGGIVIC SQVPEASPEH
560 570 580 590 600
ICQTVPPYKC LLPRTAHCSV DANRTLEQTL DRFSMGVVAI GTNMGIFLKG
610 620 630 640 650
LLEYPAYFVG NASRRRIGKC RPLSHRHEIQ QAFDVERHNR EPEGSRYASL
660 670 680
FLGRRPSPEY DWDHYPVILH IYLAPFYHRD
Length:680
Mass (Da):75,090
Last modified:March 21, 2006 - v1
Checksum:i0FBC22C8F51F3084
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28912.1.
RefSeqiYP_001129414.1. NC_009333.1.

Genome annotation databases

GeneIDi4961491.
KEGGivg:4961491.

Similar proteinsi

Entry informationi

Entry nameiVIRF2_HHV8P
AccessioniPrimary (citable) accession number: Q2HR71
Secondary accession number(s): D0UZS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: March 21, 2006
Last modified: October 25, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families