Reviewed, UniProtKB/Swiss-Prot Q2HJF7 (KCC2D_BOVIN)

Names and origin

Protein names

Recommended name:
    Calcium/calmodulin-dependent protein kinase type II delta chain
      Short name=CaM-kinase II delta chain
      Short name=CaM kinase II subunit delta
      Short name=CaMK-II subunit delta
    EC=2.7.11.17

Gene names

Name:

CAMK2D

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity By similarity.
Subunit structure	CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Calmodulin-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	Calcium/calmodulin-dependent protein kinase type II delta chain		PRO_0000277816
Regions
	Domain	14 – 272	259	Protein kinase
	Nucleotide binding	20 – 28	9	ATP By similarity
	Compositional bias	331 – 334	4	Poly-Ser
Sites
	Active site	136	1	Proton acceptor By similarity
	Binding site	43	1	ATP By similarity
Amino acid modifications
	Modified residue	3	1	Phosphoserine By similarity
	Modified residue	231	1	Phosphotyrosine By similarity
	Modified residue	287	1	Phosphothreonine By similarity
	Modified residue	315	1	Phosphoserine By similarity
	Modified residue	318	1	Phosphoserine By similarity
	Modified residue	340	1	Phosphoserine By similarity
	Modified residue	341	1	Phosphothreonine By similarity
	Modified residue	343	1	Phosphoserine By similarity
	Modified residue	347	1	Phosphothreonine By similarity
	Modified residue	482	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2HJF7-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 3D4D3A8D1F778F21	FASTA	488	55,293
	10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAKSLL KKPDGVKKRK SSSSVQMMES TESSNTTIED EDVKARKQEI 370 380 390 400 410 420 IKVTEQLIEA INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE NALSKSNKPI 430 440 450 460 470 480 HTIILNPHVH LVGDDAACIA YIRLTQYMDG SGMPKTMQSE ETRVWHRRDG KWQNVHFHRS GSPTVPIN

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC105459 mRNA. Translation: AAI05460.1.
IPI	IPI00688651.
RefSeq	NP_001039798.1.
UniGene	Bt.58299
3D structure databases
SMR	Q2HJF7. Positions 8-315, 346-484.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2HJF7.
Genome annotation databases
Ensembl	ENSBTAT00000039835; ENSBTAP00000039621; ENSBTAG00000014463; Bos taurus. [Genome view]
GeneID	532713.
KEGG	bta:532713.
Organism-specific databases
CTD	532713.
Phylogenomic databases
HOVERGEN	Q2HJF7.
OMA	CHSNGIV.
Enzyme and pathway databases
BRENDA	2.7.11.17. 251.
Family and domain databases
InterPro	IPR015742. Ca/calmodulin-dep_kinase. IPR013543. Ca/calmodulin-dep_kinase-assoc. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
PANTHER	PTHR22982:SF64. CaMKII. 1 hit.
Pfam	PF08332. CaMKII_AD. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KCC2D_BOVIN

Accession

Primary (citable) accession number: Q2HJF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	March 21, 2006
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)