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Protein

Origin recognition complex subunit 6

Gene

ORC6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-BTA-176187. Activation of ATR in response to replication stress.
R-BTA-68616. Assembly of the ORC complex at the origin of replication.
R-BTA-68689. CDC6 association with the ORC:origin complex.
R-BTA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-BTA-68867. Assembly of the pre-replicative complex.
R-BTA-68949. Orc1 removal from chromatin.
R-BTA-68962. Activation of the pre-replicative complex.
R-BTA-69300. Removal of licensing factors from origins.

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 6
Gene namesi
Name:ORC6
Synonyms:ORC6L
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Origin recognition complex subunit 6PRO_0000245346Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei195 – 1951PhosphothreonineBy similarity
Modified residuei229 – 2291PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2HJF3.
PRIDEiQ2HJF3.

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity). Interacts with DBF4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002438.

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC6 family.Curated

Phylogenomic databases

eggNOGiKOG4557. Eukaryota.
ENOG4111GUY. LUCA.
GeneTreeiENSGT00390000007370.
HOGENOMiHOG000065679.
HOVERGENiHBG007876.
InParanoidiQ2HJF3.
KOiK02608.
OMAiIFDRLCT.
OrthoDBiEOG7GTT56.
TreeFamiTF101096.

Family and domain databases

InterProiIPR008721. ORC6.
IPR020529. ORC6_met/pln.
[Graphical view]
PfamiPF05460. ORC6. 1 hit.
[Graphical view]
ProDomiPD315657. Origin_recog_cplx_su6-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q2HJF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGLIRRLA PRLGIAEQEV LRKAEEYLRL SRVKCVGLSA RTTETSNAVM
60 70 80 90 100
CLDLAASCMK CPLDRAYLIK LSGLNKKMYQ SCLKSFECLL GLNSNIGIRD
110 120 130 140 150
LAVQFSCTEA VNLASKILQS YESSLPQTQQ VDLDLSRPLF TTAALLSACK
160 170 180 190 200
ILKLKVDRNK MAATSGVKKA IFDRLCKQLE KIGQQIDREA GDSVTPPQKK
210 220 230 240 250
KKTVIEPSAK EIENVVETLP KPQKDEDLTQ DYEEWKRNIL ENAARAQKAA

TQ
Length:252
Mass (Da):28,080
Last modified:March 21, 2006 - v1
Checksum:i11D71BA2D3F75ED2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105472 mRNA. Translation: AAI05473.1.
RefSeqiNP_001039666.1. NM_001046201.2.
UniGeneiBt.3068.

Genome annotation databases

EnsembliENSBTAT00000002438; ENSBTAP00000002438; ENSBTAG00000001872.
GeneIDi515476.
KEGGibta:515476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105472 mRNA. Translation: AAI05473.1.
RefSeqiNP_001039666.1. NM_001046201.2.
UniGeneiBt.3068.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002438.

Proteomic databases

PaxDbiQ2HJF3.
PRIDEiQ2HJF3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000002438; ENSBTAP00000002438; ENSBTAG00000001872.
GeneIDi515476.
KEGGibta:515476.

Organism-specific databases

CTDi23594.

Phylogenomic databases

eggNOGiKOG4557. Eukaryota.
ENOG4111GUY. LUCA.
GeneTreeiENSGT00390000007370.
HOGENOMiHOG000065679.
HOVERGENiHBG007876.
InParanoidiQ2HJF3.
KOiK02608.
OMAiIFDRLCT.
OrthoDBiEOG7GTT56.
TreeFamiTF101096.

Enzyme and pathway databases

ReactomeiR-BTA-176187. Activation of ATR in response to replication stress.
R-BTA-68616. Assembly of the ORC complex at the origin of replication.
R-BTA-68689. CDC6 association with the ORC:origin complex.
R-BTA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-BTA-68867. Assembly of the pre-replicative complex.
R-BTA-68949. Orc1 removal from chromatin.
R-BTA-68962. Activation of the pre-replicative complex.
R-BTA-69300. Removal of licensing factors from origins.

Miscellaneous databases

NextBioi20871842.

Family and domain databases

InterProiIPR008721. ORC6.
IPR020529. ORC6_met/pln.
[Graphical view]
PfamiPF05460. ORC6. 1 hit.
[Graphical view]
ProDomiPD315657. Origin_recog_cplx_su6-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiORC6_BOVIN
AccessioniPrimary (citable) accession number: Q2HJF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 21, 2006
Last modified: May 11, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.