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Protein

Origin recognition complex subunit 6

Gene

ORC6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-BTA-176187 Activation of ATR in response to replication stress
R-BTA-68616 Assembly of the ORC complex at the origin of replication
R-BTA-68689 CDC6 association with the ORC:origin complex
R-BTA-68827 CDT1 association with the CDC6:ORC:origin complex
R-BTA-68867 Assembly of the pre-replicative complex
R-BTA-68949 Orc1 removal from chromatin
R-BTA-68962 Activation of the pre-replicative complex

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 6
Gene namesi
Name:ORC6
Synonyms:ORC6L
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:32451 ORC6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002453461 – 252Origin recognition complex subunit 6Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei195PhosphothreonineBy similarity1
Cross-linki210Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei229PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ2HJF3
PRIDEiQ2HJF3

Expressioni

Gene expression databases

BgeeiENSBTAG00000001872

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity). Interacts with DBF4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002438

Structurei

3D structure databases

SMRiQ2HJF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC6 family.Curated

Phylogenomic databases

eggNOGiKOG4557 Eukaryota
ENOG4111GUY LUCA
GeneTreeiENSGT00390000007370
HOGENOMiHOG000065679
HOVERGENiHBG007876
InParanoidiQ2HJF3
KOiK02608
OMAiRMFEKLL
OrthoDBiEOG091G0OLA
TreeFamiTF101096

Family and domain databases

InterProiView protein in InterPro
IPR008721 ORC6
IPR020529 ORC6_met/pln
PANTHERiPTHR13394 PTHR13394, 1 hit
PfamiView protein in Pfam
PF05460 ORC6, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD315657 Origin_recog_cplx_su6-like, 1 hit

Sequencei

Sequence statusi: Complete.

Q2HJF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGLIRRLA PRLGIAEQEV LRKAEEYLRL SRVKCVGLSA RTTETSNAVM
60 70 80 90 100
CLDLAASCMK CPLDRAYLIK LSGLNKKMYQ SCLKSFECLL GLNSNIGIRD
110 120 130 140 150
LAVQFSCTEA VNLASKILQS YESSLPQTQQ VDLDLSRPLF TTAALLSACK
160 170 180 190 200
ILKLKVDRNK MAATSGVKKA IFDRLCKQLE KIGQQIDREA GDSVTPPQKK
210 220 230 240 250
KKTVIEPSAK EIENVVETLP KPQKDEDLTQ DYEEWKRNIL ENAARAQKAA

TQ
Length:252
Mass (Da):28,080
Last modified:March 21, 2006 - v1
Checksum:i11D71BA2D3F75ED2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105472 mRNA Translation: AAI05473.1
RefSeqiNP_001039666.1, NM_001046201.2
UniGeneiBt.3068

Genome annotation databases

EnsembliENSBTAT00000002438; ENSBTAP00000002438; ENSBTAG00000001872
GeneIDi515476
KEGGibta:515476

Similar proteinsi

Entry informationi

Entry nameiORC6_BOVIN
AccessioniPrimary (citable) accession number: Q2HJF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 21, 2006
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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