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Q2HJD7 (3HIDH_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-hydroxyisobutyrate dehydrogenase, mitochondrial
Short name=HIBADH
EC=1.1.1.31
Gene names
Name:HIBADH
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the 3-hydroxyisobutyrate dehydrogenase family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processpentose-phosphate shunt

Inferred from electronic annotation. Source: InterPro

   Cellular componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-hydroxyisobutyrate dehydrogenase activity

Inferred from electronic annotation. Source: EC

NAD binding

Inferred from electronic annotation. Source: InterPro

phosphogluconate dehydrogenase (decarboxylating) activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3636Mitochondrion By similarity
Chain37 – 3363003-hydroxyisobutyrate dehydrogenase, mitochondrial
PRO_0000290342

Regions

Nucleotide binding40 – 6930NAD By similarity
Nucleotide binding103 – 1042NAD By similarity

Sites

Active site2091 By similarity
Binding site1081NAD By similarity
Binding site1341NAD; via amide nitrogen By similarity
Binding site2841NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2HJD7 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 11AB54F01BA8D5B8

FASTA33635,410
        10         20         30         40         50         60 
MAASLRLRGA ASGLRYWSRR QPPAVASLAA VCSRSMASKT PVGFIGVGNM GNPMAKNLMK 

        70         80         90        100        110        120 
HGYPLIIYDV FPDACKEFLD AGEQVVSSPA DVAEKADRII TMLPTSINAI EAYSGANGIL 

       130        140        150        160        170        180 
KKVKKGSLLI DSSTIDPMVS KELAKEVEKM GAVFMDAPVS GGVGAARSGN LTFMVGGVEE 

       190        200        210        220        230        240 
EFAAAQELLG CMGSNVVYCG AVGTGQAAKI CNNLLLAISM IGTAEAMNLG IRLGLDPKLL 

       250        260        270        280        290        300 
AKILNMSSGR CWSSDTYNPV PGVMDGVPSA NNYQGGFGTT LMAKDLGLAQ DSATSTKSPI 

       310        320        330 
LLGSQAHQIY RMMCAKGYSK KDFSSVFQFL REEETF

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Ascending colon.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC105543 mRNA. Translation: AAI05544.1.
IPIIPI00712360.
RefSeqNP_001039571.1. NM_001046106.1.
UniGeneBt.23720.

3D structure databases

HSSPHSSP built from PDB template 2GF2 based on UniProtKB P31937.
ProteinModelPortalQ2HJD7.
SMRQ2HJD7. Positions 41-335.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2HJD7.

Proteomic databases

PRIDEQ2HJD7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000001374; ENSBTAP00000001374; ENSBTAG00000001036.
GeneID512002.
KEGGbta:512002.

Organism-specific databases

CTD11112.

Phylogenomic databases

eggNOGmaNOG08927.
GeneTreeENSGT00530000063270.
HOVERGENHBG050424.
InParanoidQ2HJD7.
OMAPMARNLI.
OrthoDBEOG476K0N.
PhylomeDBQ2HJD7.

Family and domain databases

InterProIPR015815. 3hydroxyacid_DH/Rdtase.
IPR008927. 6-PGluconate_DH_C-like.
IPR006115. 6PGDH_NADP-bd.
IPR013328. DH_multihelical.
IPR011548. IsoBut3OH_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00020.
PANTHERPTHR22981. 3hydroxy_acid_DH. 1 hit.
PfamPF03446. NAD_binding_2. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR01692. HIBADH. 1 hit.
PROSITEPS00895. 3_HYDROXYISOBUT_DH. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name3HIDH_BOVIN
AccessionPrimary (citable) accession number: Q2HJD7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 21, 2006
Last modified: November 16, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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