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Q2HJD5 (ECHD1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ethylmalonyl-CoA decarboxylase

EC=4.1.1.94
Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase
Short name=MMCD
EC=4.1.1.41
Gene names
Name:ECHDC1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level By similarity.

Catalytic activity

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.

(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

Subcellular location

Cytoplasmcytosol By similarity.

Sequence similarities

Belongs to the enoyl-CoA hydratase/isomerase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionLyase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytosol

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functioncarboxy-lyase activity

Inferred from sequence or structural similarity. Source: UniProtKB

methylmalonyl-CoA decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Ethylmalonyl-CoA decarboxylase
PRO_0000273245

Amino acid modifications

Modified residue2161N6-acetyllysine; alternate By similarity
Modified residue2161N6-succinyllysine; alternate By similarity

Experimental info

Sequence conflict1761E → Q in AAX46345. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q2HJD5 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 380866BE4ED86C88

FASTA30633,542
        10         20         30         40         50         60 
MELKQEMASL LKTSPNAVKK RLLHQIGLSL YNTSHGFHEE EVKKKLEQFP GGSIDLQKEN 

        70         80         90        100        110        120 
SGIGILTLNN PSKMNAFSGV MMLQLLEKVI ELENWTEGKG LIIRGAKNTF SSGSDLNAVK 

       130        140        150        160        170        180 
ALGTPEDGMA VCMFMQNTLT RFMRLPLISV ALVQGRALGG GAEVTTACDF RLMTTESEIR 

       190        200        210        220        230        240 
FVHKEMGIIP SWGGATRLVE IIGGRQALKV LSGALKLDSE KALNIGMVDD ILPSSDETEC 

       250        260        270        280        290        300 
LKEAQEWLQQ FIKGPPEVIR ALKKSVSSCK ELCLEEALQR ERDILGTVWG GPANLEAVAR 


KGKFNK 

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"A whole-genome assembly of the domestic cow, Bos taurus."
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.
Genome Biol. 10:R42.01-R42.10(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hereford.
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Ascending colon.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT021498 mRNA. Translation: AAX46345.1.
DAAA02025518 Genomic DNA. No translation available.
BC105549 mRNA. Translation: AAI05550.1.
RefSeqNP_001030492.1. NM_001035415.1.
UniGeneBt.10238.

3D structure databases

ProteinModelPortalQ2HJD5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000005072.

Proteomic databases

PaxDbQ2HJD5.
PRIDEQ2HJD5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID536284.
KEGGbta:536284.

Organism-specific databases

CTD55862.

Phylogenomic databases

eggNOGCOG1024.
HOGENOMHOG000007808.
HOVERGENHBG054783.
InParanoidQ2HJD5.

Family and domain databases

Gene3D3.90.226.10. 1 hit.
InterProIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMSSF52096. SSF52096. 1 hit.
PROSITEPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20876922.

Entry information

Entry nameECHD1_BOVIN
AccessionPrimary (citable) accession number: Q2HJD5
Secondary accession number(s): F1MDK4, Q58DU9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 21, 2006
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families