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Q2HJD5

- ECHD1_BOVIN

UniProt

Q2HJD5 - ECHD1_BOVIN

Protein

Ethylmalonyl-CoA decarboxylase

Gene

ECHDC1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level By similarity.By similarity

    Catalytic activityi

    (S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
    (S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

    GO - Molecular functioni

    1. carboxy-lyase activity Source: UniProtKB
    2. methylmalonyl-CoA decarboxylase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Lyase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
    Alternative name(s):
    Enoyl-CoA hydratase domain-containing protein 1
    Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
    Short name:
    MMCD
    Gene namesi
    Name:ECHDC1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306Ethylmalonyl-CoA decarboxylasePRO_0000273245Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei216 – 2161N6-acetyllysine; alternateBy similarity
    Modified residuei216 – 2161N6-succinyllysine; alternateBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ2HJD5.
    PRIDEiQ2HJD5.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000005072.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2HJD5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1024.
    HOGENOMiHOG000007808.
    HOVERGENiHBG054783.
    InParanoidiQ2HJD5.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    InterProiIPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR018376. Enoyl-CoA_hyd/isom_CS.
    [Graphical view]
    PfamiPF00378. ECH. 1 hit.
    [Graphical view]
    SUPFAMiSSF52096. SSF52096. 1 hit.
    PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2HJD5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELKQEMASL LKTSPNAVKK RLLHQIGLSL YNTSHGFHEE EVKKKLEQFP    50
    GGSIDLQKEN SGIGILTLNN PSKMNAFSGV MMLQLLEKVI ELENWTEGKG 100
    LIIRGAKNTF SSGSDLNAVK ALGTPEDGMA VCMFMQNTLT RFMRLPLISV 150
    ALVQGRALGG GAEVTTACDF RLMTTESEIR FVHKEMGIIP SWGGATRLVE 200
    IIGGRQALKV LSGALKLDSE KALNIGMVDD ILPSSDETEC LKEAQEWLQQ 250
    FIKGPPEVIR ALKKSVSSCK ELCLEEALQR ERDILGTVWG GPANLEAVAR 300
    KGKFNK 306
    Length:306
    Mass (Da):33,542
    Last modified:March 21, 2006 - v1
    Checksum:i380866BE4ED86C88
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti176 – 1761E → Q in AAX46345. (PubMed:16305752)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021498 mRNA. Translation: AAX46345.1.
    DAAA02025518 Genomic DNA. No translation available.
    BC105549 mRNA. Translation: AAI05550.1.
    RefSeqiNP_001030492.1. NM_001035415.1.
    UniGeneiBt.10238.

    Genome annotation databases

    GeneIDi536284.
    KEGGibta:536284.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021498 mRNA. Translation: AAX46345.1 .
    DAAA02025518 Genomic DNA. No translation available.
    BC105549 mRNA. Translation: AAI05550.1 .
    RefSeqi NP_001030492.1. NM_001035415.1.
    UniGenei Bt.10238.

    3D structure databases

    ProteinModelPortali Q2HJD5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000005072.

    Proteomic databases

    PaxDbi Q2HJD5.
    PRIDEi Q2HJD5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 536284.
    KEGGi bta:536284.

    Organism-specific databases

    CTDi 55862.

    Phylogenomic databases

    eggNOGi COG1024.
    HOGENOMi HOG000007808.
    HOVERGENi HBG054783.
    InParanoidi Q2HJD5.

    Miscellaneous databases

    NextBioi 20876922.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    InterProi IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR018376. Enoyl-CoA_hyd/isom_CS.
    [Graphical view ]
    Pfami PF00378. ECH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52096. SSF52096. 1 hit.
    PROSITEi PS00166. ENOYL_COA_HYDRATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hereford.
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Ascending colon.

    Entry informationi

    Entry nameiECHD1_BOVIN
    AccessioniPrimary (citable) accession number: Q2HJD5
    Secondary accession number(s): F1MDK4, Q58DU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3