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Protein

FAS-associated factor 2

Gene

FAF2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUnfolded protein response

Enzyme and pathway databases

ReactomeiR-BTA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
FAS-associated factor 2
Alternative name(s):
UBX domain-containing protein 8
Gene namesi
Name:FAF2
Synonyms:UBXD8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Lipid droplet

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002440632 – 445FAS-associated factor 2Add BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei167N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2HJD0.
PRIDEiQ2HJD0.

Expressioni

Gene expression databases

BgeeiENSBTAG00000017744.

Interactioni

Subunit structurei

Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1. Interacts (via N-terminus) with UBQLN2 (via C-terminus). Interacts with PNPLA2 and UBAC2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000052507.

Structurei

3D structure databases

ProteinModelPortaliQ2HJD0.
SMRiQ2HJD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 48UBAAdd BLAST37
Domaini357 – 439UBXPROSITE-ProRule annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili275 – 350Sequence analysisAdd BLAST76

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1363. Eukaryota.
ENOG410XSFS. LUCA.
GeneTreeiENSGT00530000063422.
HOGENOMiHOG000007539.
HOVERGENiHBG101311.
InParanoidiQ2HJD0.
KOiK18726.
OMAiHQDTDEF.
OrthoDBiEOG091G07IN.
TreeFamiTF314172.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
PfamiView protein in Pfam
PF00789. UBX. 1 hit.
SMARTiView protein in SMART
SM00594. UAS. 1 hit.
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50033. UBX. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2HJD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPEERDLT QEQTEKLLQF QDLTGIESMD QCRHTLEQHN WNIEAAVQDR
60 70 80 90 100
LNEQEGVPSV FNPPPSRPLQ VNTADHRIYS YVVSRPQPRG LLGWGYYLIM
110 120 130 140 150
LPFRFTYYTI LDIFRFALRF IRPDPRNRVT DPVGDIVSFM HSFEEKYGRA
160 170 180 190 200
HPVFYLGTYS QALNDAKREL RFLLVYLHGD DHQDSDEFCR NTLCAPEVIS
210 220 230 240 250
LINTRMLFWA CSTNKPEGYR VSQALRENTY PFLAMIMLKD RRMTVVGRLE
260 270 280 290 300
GLIQPDDLIN QLTFIMDANQ TYLVSERLER EERNQTQVLR QQQDEAYLAS
310 320 330 340 350
LRADQEKERK KREERERKRR KEEEVQQQKL AEERRRRNLQ EEKERKLECL
360 370 380 390 400
PPEPSPDDPE SVKIIFKLPN DSRVERRFHF SQSLTVIHDF LFSLKESPEK
410 420 430 440
FQIEANFPRR VLPCLPSEEW PNPPTLQEAG LSHTEVLFVQ DLTDE
Length:445
Mass (Da):52,664
Last modified:March 21, 2006 - v1
Checksum:i42979FF2F5E38119
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105572 mRNA. Translation: AAI05573.1.
RefSeqiNP_001070488.1. NM_001077020.1.
UniGeneiBt.26767.

Genome annotation databases

EnsembliENSBTAT00000057329; ENSBTAP00000052507; ENSBTAG00000017744.
GeneIDi767948.
KEGGibta:767948.

Similar proteinsi

Entry informationi

Entry nameiFAF2_BOVIN
AccessioniPrimary (citable) accession number: Q2HJD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 21, 2006
Last modified: September 27, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome