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Protein

Palmitoyltransferase ZDHHC6

Gene

ZDHHC6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC6 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 6
Short name:
DHHC-6
Gene namesi
Name:ZDHHC6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 26

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002692271 – 413Palmitoyltransferase ZDHHC6Add BLAST413

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ2HJ95.
PRIDEiQ2HJ95.

Expressioni

Gene expression databases

BgeeiENSBTAG00000006713.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008828.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 149DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1314. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00870000136467.
HOGENOMiHOG000017896.
HOVERGENiHBG054221.
InParanoidiQ2HJ95.
KOiK20031.
OMAiWFPRRCV.
OrthoDBiEOG091G0HOK.
TreeFamiTF320809.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
IPR011511. SH3_2.
PfamiView protein in Pfam
PF07653. SH3_2. 1 hit.
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2HJ95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTFCSVVKF ENLQELKRLC HWGPIIALGV IAICSAMAMI DSVLWYWPLH
60 70 80 90 100
TTGGSVNFIM LINWTVMILY NYFNAMFVGP GFVPLGWKPE NSQDSVYLQY
110 120 130 140 150
CKVCQAYKAP RSHHCRKCNR CVMKMDHHCP WINNCCGYQN HASFTLFLLL
160 170 180 190 200
APLGCIHAAF IFVMTMYTQL YNRLSFGWNT VKIDMSAARR DPLPIIPFGL
210 220 230 240 250
AAFAATLFAL GLALGTTIAV GMLFFIQMKI ILRNKTSIES WIEEKAKDRI
260 270 280 290 300
QYYQLDEVFV FPYDMGSRWK NFKQVFTWSG VPEGDGLDWP IREGCHQYSL
310 320 330 340 350
TIEQLKQKAD KRVRSVRYKV IEDYSGTCCP LNRGIKTFFT SPCTEEPRIR
360 370 380 390 400
LQKGEFILAT RGLRYWLYGD KILDDSVLEG VSRIRGWFPR NCVEKCPCDA
410
ETDQAPEGEK KNR
Length:413
Mass (Da):47,531
Last modified:March 21, 2006 - v1
Checksum:i76DD8EDA86EE57BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113243 mRNA. Translation: AAI13244.1.
RefSeqiNP_001039632.1. NM_001046167.1.
UniGeneiBt.6696.

Genome annotation databases

EnsembliENSBTAT00000008828; ENSBTAP00000008828; ENSBTAG00000006713.
GeneIDi514158.
KEGGibta:514158.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113243 mRNA. Translation: AAI13244.1.
RefSeqiNP_001039632.1. NM_001046167.1.
UniGeneiBt.6696.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008828.

Proteomic databases

PaxDbiQ2HJ95.
PRIDEiQ2HJ95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000008828; ENSBTAP00000008828; ENSBTAG00000006713.
GeneIDi514158.
KEGGibta:514158.

Organism-specific databases

CTDi64429.

Phylogenomic databases

eggNOGiKOG1314. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00870000136467.
HOGENOMiHOG000017896.
HOVERGENiHBG054221.
InParanoidiQ2HJ95.
KOiK20031.
OMAiWFPRRCV.
OrthoDBiEOG091G0HOK.
TreeFamiTF320809.

Gene expression databases

BgeeiENSBTAG00000006713.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
IPR011511. SH3_2.
PfamiView protein in Pfam
PF07653. SH3_2. 1 hit.
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC6_BOVIN
AccessioniPrimary (citable) accession number: Q2HJ95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 21, 2006
Last modified: March 15, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.