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Protein

DnaJ homolog subfamily A member 2

Gene

DNAJA2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Co-chaperone of Hsc70.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi143Zinc 1By similarity1
Metal bindingi146Zinc 1By similarity1
Metal bindingi159Zinc 2By similarity1
Metal bindingi162Zinc 2By similarity1
Metal bindingi186Zinc 2By similarity1
Metal bindingi189Zinc 2By similarity1
Metal bindingi202Zinc 1By similarity1
Metal bindingi205Zinc 1By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 214CR-typeAdd BLAST85

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily A member 2
Gene namesi
Name:DNAJA2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002900261 – 409DnaJ homolog subfamily A member 2Add BLAST409
PropeptideiPRO_0000396757410 – 412Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39N6-acetyllysineBy similarity1
Modified residuei78PhosphoserineBy similarity1
Modified residuei123PhosphoserineBy similarity1
Modified residuei152N6-acetyllysineBy similarity1
Modified residuei391PhosphotyrosineBy similarity1
Modified residuei394PhosphoserineBy similarity1
Modified residuei395PhosphoserineBy similarity1
Modified residuei409Cysteine methyl esterBy similarity1
Lipidationi409S-farnesyl cysteineBy similarity1

Post-translational modificationi

Farnesylated.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ2HJ94.
PRIDEiQ2HJ94.

Expressioni

Gene expression databases

BgeeiENSBTAG00000003757.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004890.

Structurei

3D structure databases

ProteinModelPortaliQ2HJ94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 70JAdd BLAST63
Repeati143 – 150CXXCXGXG motif8
Repeati159 – 166CXXCXGXG motif8
Repeati186 – 193CXXCXGXG motif8
Repeati202 – 209CXXCXGXG motif8

Sequence similaritiesi

Contains 1 CR-type zinc finger.Curated
Contains 1 J domain.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 214CR-typeAdd BLAST85

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0712. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00860000133716.
HOGENOMiHOG000226718.
HOVERGENiHBG066727.
InParanoidiQ2HJ94.
KOiK09503.
OMAiRSEPPII.
OrthoDBiEOG091G0CAC.
TreeFamiTF105141.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
2.10.230.10. 1 hit.
HAMAPiMF_01152. DnaJ. 1 hit.
InterProiIPR012724. DnaJ.
IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
IPR001305. HSP_DnaJ_Cys-rich_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 3 hits.
SSF57938. SSF57938. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2HJ94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANVADTKLY DILGVPPGAS ENELKKAYRK LAKEYHPDKN PNAGDKFKEI
60 70 80 90 100
SFAYEVLSNP EKRELYDRYG EQGLREGSGG GGGMDDIFSH IFGGGLFSFM
110 120 130 140 150
GNQSRSRNGR RRGEDMMHPL KVSLEDLYNG KTTKLQLSKN VLCSACSGQG
160 170 180 190 200
GKSGAVQKCS ACRGRGVRIM IRQLAPGMVQ QMQSVCSDCN GEGEVINEKD
210 220 230 240 250
RCKKCEGKKV IKEVKILEVH VDKGMKHGQR ITFTGEADQA PGVEPGDIVL
260 270 280 290 300
LLQEKEHEVF QRDGNDLHMT YKIGLVEALC GFQFTFKHLD GRQIVVKYPP
310 320 330 340 350
GKVIEPGCVR VVRGEGMPQY RNPFEKGDLY IKFDVQFPEN NWINPDKLSE
360 370 380 390 400
LEDLLPSRPE VPNIIGDTEE VELQEFDSTR GSGGGQRREA YNDSSDEESS
410
SHHGPGVQCA HQ
Length:412
Mass (Da):45,762
Last modified:March 21, 2006 - v1
Checksum:i27674EA20658ADE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113244 mRNA. Translation: AAI13245.1.
RefSeqiNP_001035581.1. NM_001040491.1.
UniGeneiBt.7595.

Genome annotation databases

EnsembliENSBTAT00000004890; ENSBTAP00000004890; ENSBTAG00000003757.
GeneIDi360006.
KEGGibta:360006.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113244 mRNA. Translation: AAI13245.1.
RefSeqiNP_001035581.1. NM_001040491.1.
UniGeneiBt.7595.

3D structure databases

ProteinModelPortaliQ2HJ94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004890.

Proteomic databases

PaxDbiQ2HJ94.
PRIDEiQ2HJ94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004890; ENSBTAP00000004890; ENSBTAG00000003757.
GeneIDi360006.
KEGGibta:360006.

Organism-specific databases

CTDi10294.

Phylogenomic databases

eggNOGiKOG0712. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00860000133716.
HOGENOMiHOG000226718.
HOVERGENiHBG066727.
InParanoidiQ2HJ94.
KOiK09503.
OMAiRSEPPII.
OrthoDBiEOG091G0CAC.
TreeFamiTF105141.

Gene expression databases

BgeeiENSBTAG00000003757.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
2.10.230.10. 1 hit.
HAMAPiMF_01152. DnaJ. 1 hit.
InterProiIPR012724. DnaJ.
IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
IPR001305. HSP_DnaJ_Cys-rich_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 3 hits.
SSF57938. SSF57938. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNJA2_BOVIN
AccessioniPrimary (citable) accession number: Q2HJ94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 21, 2006
Last modified: November 30, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.