ID   FKB10_BOVIN             Reviewed;         583 AA.
AC   Q2HJ89;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 32.
DE   RecName: Full=FK506-binding protein 10;
DE            EC=5.2.1.8;
DE   AltName: Full=Peptidyl-prolyl cis-trans isomerase;
DE            Short=PPIase;
DE            Short=Rotamase;
DE   Flags: Precursor;
GN   Name=FKBP10;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: PPIases accelerate the folding of proteins during
CC       protein synthesis.
CC   -!- CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline
CC       (omega=0).
CC   -!- ENZYME REGULATION: Inhibited by both FK506 and rapamycin, but not
CC       by cyclosporin A (By similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (By similarity).
CC   -!- PTM: Glycosylated and phosphorylated (By similarity).
CC   -!- SIMILARITY: Contains 2 EF-hand domains.
CC   -!- SIMILARITY: Contains 4 PPIase FKBP-type domains.
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DR   EMBL; BC113250; AAI13251.1; -; mRNA.
DR   IPI; IPI00697856; -.
DR   RefSeq; NP_001039868.1; -.
DR   UniGene; Bt.2698; -.
DR   Ensembl; ENSBTAG00000011454; Bos taurus.
DR   GeneID; 535310; -.
DR   KEGG; bta:535310; -.
DR   HOVERGEN; Q2HJ89; -.
DR   OMA; Q2HJ89; DRGLMGM.
DR   BRENDA; 5.2.1.8; 251.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-KW.
DR   InterPro; IPR011992; EF-Hand_type.
DR   InterPro; IPR018247; EF_HAND_1.
DR   InterPro; IPR018249; EF_HAND_2.
DR   InterPro; IPR002048; EF_hand_Ca_bd.
DR   InterPro; IPR000886; ER_targeting_sequence.
DR   InterPro; IPR001179; PPIase_FKBP.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 1.
DR   PANTHER; PTHR10516; PPIase_FKBP; 1.
DR   Pfam; PF00254; FKBP_C; 4.
DR   SMART; SM00054; EFh; 2.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS00014; ER_TARGET; 1.
DR   PROSITE; PS50059; FKBP_PPIASE; 4.
PE   2: Evidence at transcript level;
KW   Calcium; Endoplasmic reticulum; Glycoprotein; Isomerase;
KW   Phosphoprotein; Repeat; Rotamase; Signal.
FT   SIGNAL        1     27       Potential.
FT   CHAIN        28    583       FK506-binding protein 10.
FT                                /FTId=PRO_0000285594.
FT   DOMAIN       63    151       PPIase FKBP-type 1.
FT   DOMAIN      175    263       PPIase FKBP-type 2.
FT   DOMAIN      287    375       PPIase FKBP-type 3.
FT   DOMAIN      400    487       PPIase FKBP-type 4.
FT   DOMAIN      498    533       EF-hand 1.
FT   DOMAIN      543    578       EF-hand 2.
FT   CA_BIND     511    522       1 (Potential).
FT   CA_BIND     556    567       2 (Potential).
FT   MOTIF       580    583       Prevents secretion from ER (Potential).
FT   CARBOHYD     71     71       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    183    183       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    295    295       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   583 AA;  64484 MW;  E651201D6D74D5F6 CRC64;
     MLRAGPPSHT LLRLPLLQLL LLLLVQAVGR GLGRASPAGG PLEDVVIERY HIPRVCPREV
     QMGDFVRYHY NGTFEDGKKF DSSYDRHTLV AIVVGVGRLI TGMDRGLMGM CVNERRRLIV
     PPHLGYGSIG VAGLIPPDAT LYFDVVLLDV WNKEDTVQVS TLLRPPHCPR MVQDSDFVRY
     HYNGTLLDGT AFDTSYSKGG TYDTYVGSGW LIKGMDQGLL GMCPGERRKI VIPPFLAYGE
     KGYGTVIPSQ ASLVFHVLLI DVHNPKDTVQ LETLELPPGC VRRAVAGDFM RYHYNGSLMD
     GTLFDSSYSR NHTYNTYVGQ GYIIPGMDQG LQGSCMGERR RITIPPHLAY GENGTGDKIP
     GSAVLIFDVH VIDFHNPADP VEIKTLSRPL ETCNETAKLG DFVHYHYNCS LLDGTRLFSS
     HDYGAPQEAT LGAHKVIEGL DTGLQGMCVG ERRQLVVPPH LAHGESGARG VPGSAVLLFE
     VELVSREDGL PTGYLFVWHE DPPAHLFEHM DLNKDGEVPV EEFSTFIKAQ VSEGKGRLLP
     GQDPEKTIGD MFQNQDRNQD GKITAEELKL KSDEDQDRVH EEL
//