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Q2HJ89

- FKB10_BOVIN

UniProt

Q2HJ89 - FKB10_BOVIN

Protein

Peptidyl-prolyl cis-trans isomerase FKBP10

Gene

FKBP10

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins during protein synthesis.

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Enzyme regulationi

    Inhibited by both FK506 and rapamycin, but not by cyclosporin A.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi511 – 522121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi556 – 567122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP10 (EC:5.2.1.8)
    Short name:
    PPIase FKBP10
    Alternative name(s):
    FK506-binding protein 10
    Short name:
    FKBP-10
    Rotamase
    Gene namesi
    Name:FKBP10
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 583556Peptidyl-prolyl cis-trans isomerase FKBP10PRO_0000285594Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated and phosphorylated.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ2HJ89.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000015220.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2HJ89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 15189PPIase FKBP-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini175 – 26389PPIase FKBP-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini287 – 37589PPIase FKBP-type 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini400 – 48788PPIase FKBP-type 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini498 – 53336EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini543 – 57836EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi580 – 5834Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 4 PPIase FKBP-type domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0545.
    HOGENOMiHOG000230960.
    HOVERGENiHBG051620.
    InParanoidiQ2HJ89.
    KOiK09575.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF13202. EF-hand_5. 2 hits.
    PF00254. FKBP_C. 4 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2HJ89-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRAGPPSHT LLRLPLLQLL LLLLVQAVGR GLGRASPAGG PLEDVVIERY    50
    HIPRVCPREV QMGDFVRYHY NGTFEDGKKF DSSYDRHTLV AIVVGVGRLI 100
    TGMDRGLMGM CVNERRRLIV PPHLGYGSIG VAGLIPPDAT LYFDVVLLDV 150
    WNKEDTVQVS TLLRPPHCPR MVQDSDFVRY HYNGTLLDGT AFDTSYSKGG 200
    TYDTYVGSGW LIKGMDQGLL GMCPGERRKI VIPPFLAYGE KGYGTVIPSQ 250
    ASLVFHVLLI DVHNPKDTVQ LETLELPPGC VRRAVAGDFM RYHYNGSLMD 300
    GTLFDSSYSR NHTYNTYVGQ GYIIPGMDQG LQGSCMGERR RITIPPHLAY 350
    GENGTGDKIP GSAVLIFDVH VIDFHNPADP VEIKTLSRPL ETCNETAKLG 400
    DFVHYHYNCS LLDGTRLFSS HDYGAPQEAT LGAHKVIEGL DTGLQGMCVG 450
    ERRQLVVPPH LAHGESGARG VPGSAVLLFE VELVSREDGL PTGYLFVWHE 500
    DPPAHLFEHM DLNKDGEVPV EEFSTFIKAQ VSEGKGRLLP GQDPEKTIGD 550
    MFQNQDRNQD GKITAEELKL KSDEDQDRVH EEL 583
    Length:583
    Mass (Da):64,484
    Last modified:March 21, 2006 - v1
    Checksum:iE651201D6D74D5F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC113250 mRNA. Translation: AAI13251.1.
    RefSeqiNP_001039868.1. NM_001046403.1.
    UniGeneiBt.2698.

    Genome annotation databases

    GeneIDi535310.
    KEGGibta:535310.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC113250 mRNA. Translation: AAI13251.1 .
    RefSeqi NP_001039868.1. NM_001046403.1.
    UniGenei Bt.2698.

    3D structure databases

    ProteinModelPortali Q2HJ89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000015220.

    Proteomic databases

    PRIDEi Q2HJ89.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 535310.
    KEGGi bta:535310.

    Organism-specific databases

    CTDi 60681.

    Phylogenomic databases

    eggNOGi COG0545.
    HOGENOMi HOG000230960.
    HOVERGENi HBG051620.
    InParanoidi Q2HJ89.
    KOi K09575.

    Miscellaneous databases

    NextBioi 20876693.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF13202. EF-hand_5. 2 hits.
    PF00254. FKBP_C. 4 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Uterus.

    Entry informationi

    Entry nameiFKB10_BOVIN
    AccessioniPrimary (citable) accession number: Q2HJ89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3