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Q2HJ89 (FKB10_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase FKBP10

Short name=PPIase FKBP10
EC=5.2.1.8
Alternative name(s):
FK506-binding protein 10
Short name=FKBP-10
Rotamase
Gene names
Name:FKBP10
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length583 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by both FK506 and rapamycin, but not by cyclosporin A By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Post-translational modification

Glycosylated and phosphorylated By similarity.

Sequence similarities

Contains 2 EF-hand domains.

Contains 4 PPIase FKBP-type domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 583556Peptidyl-prolyl cis-trans isomerase FKBP10
PRO_0000285594

Regions

Domain63 – 15189PPIase FKBP-type 1
Domain175 – 26389PPIase FKBP-type 2
Domain287 – 37589PPIase FKBP-type 3
Domain400 – 48788PPIase FKBP-type 4
Domain498 – 53336EF-hand 1
Domain543 – 57836EF-hand 2
Calcium binding511 – 522121 Potential
Calcium binding556 – 567122 Potential
Motif580 – 5834Prevents secretion from ER Potential

Amino acid modifications

Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation1831N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q2HJ89 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: E651201D6D74D5F6

FASTA58364,484
        10         20         30         40         50         60 
MLRAGPPSHT LLRLPLLQLL LLLLVQAVGR GLGRASPAGG PLEDVVIERY HIPRVCPREV 

        70         80         90        100        110        120 
QMGDFVRYHY NGTFEDGKKF DSSYDRHTLV AIVVGVGRLI TGMDRGLMGM CVNERRRLIV 

       130        140        150        160        170        180 
PPHLGYGSIG VAGLIPPDAT LYFDVVLLDV WNKEDTVQVS TLLRPPHCPR MVQDSDFVRY 

       190        200        210        220        230        240 
HYNGTLLDGT AFDTSYSKGG TYDTYVGSGW LIKGMDQGLL GMCPGERRKI VIPPFLAYGE 

       250        260        270        280        290        300 
KGYGTVIPSQ ASLVFHVLLI DVHNPKDTVQ LETLELPPGC VRRAVAGDFM RYHYNGSLMD 

       310        320        330        340        350        360 
GTLFDSSYSR NHTYNTYVGQ GYIIPGMDQG LQGSCMGERR RITIPPHLAY GENGTGDKIP 

       370        380        390        400        410        420 
GSAVLIFDVH VIDFHNPADP VEIKTLSRPL ETCNETAKLG DFVHYHYNCS LLDGTRLFSS 

       430        440        450        460        470        480 
HDYGAPQEAT LGAHKVIEGL DTGLQGMCVG ERRQLVVPPH LAHGESGARG VPGSAVLLFE 

       490        500        510        520        530        540 
VELVSREDGL PTGYLFVWHE DPPAHLFEHM DLNKDGEVPV EEFSTFIKAQ VSEGKGRLLP 

       550        560        570        580 
GQDPEKTIGD MFQNQDRNQD GKITAEELKL KSDEDQDRVH EEL 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC113250 mRNA. Translation: AAI13251.1.
RefSeqNP_001039868.1. NM_001046403.1.
UniGeneBt.2698.

3D structure databases

ProteinModelPortalQ2HJ89.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000015220.

Proteomic databases

PRIDEQ2HJ89.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID535310.
KEGGbta:535310.

Organism-specific databases

CTD60681.

Phylogenomic databases

eggNOGCOG0545.
HOGENOMHOG000230960.
HOVERGENHBG051620.
InParanoidQ2HJ89.
KOK09575.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF13202. EF-hand_5. 2 hits.
PF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20876693.

Entry information

Entry nameFKB10_BOVIN
AccessionPrimary (citable) accession number: Q2HJ89
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 21, 2006
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families