ID RTCA_BOVIN Reviewed; 366 AA. AC Q2HJ88; DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot. DT 21-MAR-2006, sequence version 1. DT 27-MAR-2024, entry version 112. DE RecName: Full=RNA 3'-terminal phosphate cyclase; DE Short=RNA cyclase; DE Short=RNA-3'-phosphate cyclase; DE EC=6.5.1.4 {ECO:0000250|UniProtKB:O00442}; DE AltName: Full=RNA terminal phosphate cyclase domain-containing protein 1; GN Name=RTCA; Synonyms=RTCD1; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Hereford; TISSUE=Uterus; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic CC phosphodiester at the end of RNA (By similarity). The mechanism of CC action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme CC by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- CC N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'- CC phosphorus in the diester linkage to produce the cyclic end product (By CC similarity). Likely functions in some aspects of cellular RNA CC processing (By similarity). Function plays an important role in CC regulating axon regeneration by inhibiting central nervous system (CNS) CC axon regeneration following optic nerve injury (By similarity). CC {ECO:0000250|UniProtKB:O00442, ECO:0000250|UniProtKB:Q9D7H3}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'- CC cyclophospho-ribonucleotide-RNA + AMP + diphosphate; CC Xref=Rhea:RHEA:23976, Rhea:RHEA-COMP:10463, Rhea:RHEA-COMP:10464, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:83062, CC ChEBI:CHEBI:83064, ChEBI:CHEBI:456215; EC=6.5.1.4; CC Evidence={ECO:0000250|UniProtKB:O00442}; CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm CC {ECO:0000250|UniProtKB:O00442}. CC -!- SIMILARITY: Belongs to the RNA 3'-terminal cyclase family. Type 1 CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC113251; AAI13252.1; -; mRNA. DR RefSeq; NP_001039520.1; NM_001046055.1. DR AlphaFoldDB; Q2HJ88; -. DR SMR; Q2HJ88; -. DR STRING; 9913.ENSBTAP00000008293; -. DR PaxDb; 9913-ENSBTAP00000008293; -. DR Ensembl; ENSBTAT00000008293.6; ENSBTAP00000008293.5; ENSBTAG00000006321.6. DR GeneID; 510469; -. DR KEGG; bta:510469; -. DR CTD; 8634; -. DR VEuPathDB; HostDB:ENSBTAG00000006321; -. DR VGNC; VGNC:34193; RTCA. DR eggNOG; KOG3980; Eukaryota. DR GeneTree; ENSGT00530000063404; -. DR HOGENOM; CLU_027882_0_1_1; -. DR InParanoid; Q2HJ88; -. DR OMA; WSPPIDY; -. DR OrthoDB; 315241at2759; -. DR TreeFam; TF300831; -. DR Proteomes; UP000009136; Chromosome 3. DR Bgee; ENSBTAG00000006321; Expressed in semen and 106 other cell types or tissues. DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003963; F:RNA-3'-phosphate cyclase activity; ISS:UniProtKB. DR GO; GO:0006396; P:RNA processing; IEA:InterPro. DR CDD; cd00874; RNA_Cyclase_Class_II; 1. DR Gene3D; 3.65.10.20; RNA 3'-terminal phosphate cyclase domain; 1. DR Gene3D; 3.30.360.20; RNA 3'-terminal phosphate cyclase, insert domain; 1. DR HAMAP; MF_00200; RTC; 1. DR InterPro; IPR013791; RNA3'-term_phos_cycl_insert. DR InterPro; IPR023797; RNA3'_phos_cyclase_dom. DR InterPro; IPR037136; RNA3'_phos_cyclase_dom_sf. DR InterPro; IPR000228; RNA3'_term_phos_cyc. DR InterPro; IPR017770; RNA3'_term_phos_cyc_type_1. DR InterPro; IPR020719; RNA3'_term_phos_cycl-like_CS. DR InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b. DR InterPro; IPR036553; RPTC_insert. DR NCBIfam; TIGR03399; RNA_3prim_cycl; 1. DR PANTHER; PTHR11096; RNA 3' TERMINAL PHOSPHATE CYCLASE; 1. DR PANTHER; PTHR11096:SF0; RNA 3'-TERMINAL PHOSPHATE CYCLASE; 1. DR Pfam; PF01137; RTC; 1. DR Pfam; PF05189; RTC_insert; 1. DR PIRSF; PIRSF005378; RNA3'_term_phos_cycl_euk; 1. DR SUPFAM; SSF55205; EPT/RTPC-like; 2. DR SUPFAM; SSF52913; RNA 3'-terminal phosphate cyclase, RPTC, insert domain; 1. DR PROSITE; PS01287; RTC; 1. PE 2: Evidence at transcript level; KW ATP-binding; Ligase; Nucleotide-binding; Nucleus; Reference proteome. FT CHAIN 1..366 FT /note="RNA 3'-terminal phosphate cyclase" FT /id="PRO_0000288837" FT ACT_SITE 320 FT /note="Tele-AMP-histidine intermediate" FT /evidence="ECO:0000250|UniProtKB:P46849" FT BINDING 104 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000250|UniProtKB:P46849" FT BINDING 131 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000250|UniProtKB:P46849" FT BINDING 294 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000250|UniProtKB:P46849" FT BINDING 297 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000250|UniProtKB:P46849" FT BINDING 298 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000250|UniProtKB:P46849" FT BINDING 320 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000250|UniProtKB:P46849" SQ SEQUENCE 366 AA; 39252 MW; 417C040DBA122145 CRC64; MAGPRVEVDG GIMEGGGQIL RVSTALSCLL GLPLRVQKIR AGRSTPGLRP QHLSGLEMIR DLCDGQLEGA EIGSTEITFT PEKIKGGVHT ADTKTAGSVC LLMQVSMPCV LFAACPSELR LKGGTNAEMA PQIDYTAMVF KPIVEKFGFT FNCDIKMRGY YPKGGGEVIV RMSPVKQLSP INLTDRGCVT KIYGRAFVAG VLPFKVAKDM AAAAVRCIRK EIRDLYVNIQ PVQEPKDQAF GNGNGIIIIA ETSTGCLFAG SSLGKRGVNA DKVGIEAAEM LLANLRHGGA VDEYLQDQLI IFMALASGIS RIKTGPVTLH TQTAIHFAEQ LAKAKFTVKK SEDEEDASKD TYIIECQGIG MTNPNL //