Reviewed, UniProtKB/Swiss-Prot Q2HJ88 (RTC1_BOVIN)

Names and origin

Protein names

Recommended name:
    RNA 3'-terminal phosphate cyclase
      Short name=RNA-3'-phosphate cyclase
      Short name=RNA cyclase
    EC=6.5.1.4
Alternative name(s):
    RNA terminal phosphate cyclase domain-containing protein 1

Gene names

Name:

RTCD1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) the enzyme acts on RNA-N3'P to produce RNA-N3'PP5'A; (C) a non catalytic nucleophilic attack by the adjacent 2'hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing By similarity.
Catalytic activity	ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate.
Subunit structure	Monomer By similarity.
Subcellular location	Nucleus › nucleoplasm By similarity.
Sequence similarities	Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Gene Ontology (GO)
Biological process	RNA processing Inferred from electronic annotation. Source: InterPro
Cellular component	nucleoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA-3'-phosphate cyclase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	RNA 3'-terminal phosphate cyclase		PRO_0000288837
Sites
	Active site	320	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2HJ88-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 417C040DBA122145	FASTA	366	39,252
	10 20 30 40 50 60 MAGPRVEVDG GIMEGGGQIL RVSTALSCLL GLPLRVQKIR AGRSTPGLRP QHLSGLEMIR 70 80 90 100 110 120 DLCDGQLEGA EIGSTEITFT PEKIKGGVHT ADTKTAGSVC LLMQVSMPCV LFAACPSELR 130 140 150 160 170 180 LKGGTNAEMA PQIDYTAMVF KPIVEKFGFT FNCDIKMRGY YPKGGGEVIV RMSPVKQLSP 190 200 210 220 230 240 INLTDRGCVT KIYGRAFVAG VLPFKVAKDM AAAAVRCIRK EIRDLYVNIQ PVQEPKDQAF 250 260 270 280 290 300 GNGNGIIIIA ETSTGCLFAG SSLGKRGVNA DKVGIEAAEM LLANLRHGGA VDEYLQDQLI 310 320 330 340 350 360 IFMALASGIS RIKTGPVTLH TQTAIHFAEQ LAKAKFTVKK SEDEEDASKD TYIIECQGIG MTNPNL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Uterus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC113251 mRNA. Translation: AAI13252.1.
IPI	IPI00705240.
RefSeq	NP_001039520.1.
UniGene	Bt.20917
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2HJ88.
Genome annotation databases
Ensembl	ENSBTAT00000008293; ENSBTAP00000008293; ENSBTAG00000006321; Bos taurus. [Genome view]
GeneID	510469.
KEGG	bta:510469.
Organism-specific databases
CTD	510469.
Phylogenomic databases
HOVERGEN	Q2HJ88.
Enzyme and pathway databases
BRENDA	6.5.1.4. 251.
Family and domain databases
InterPro	IPR000228. RNA3'_term_phos_cycl-like. IPR016443. RNA3'_term_phos_cycl-like_euk. IPR013796. RNA3'_term_phos_cycl_insert. IPR017770. RNA3'_term_phos_cycl_sub. [Graphical view]
Gene3D	G3DSA:3.65.10.20. RNA3'_term_phos_cycl. 1 hit.
PANTHER	PTHR11096. RNA3'_term_phos_cycl. 1 hit.
Pfam	PF01137. RTC. 1 hit. PF05189. RTC_insert. 1 hit. [Graphical view]
PIRSF	PIRSF005378. RNA3'_term_phos_cycl_euk. 1 hit.
TIGRFAMs	TIGR03399. RNA_3prim_cycl. 1 hit.
PROSITE	PS01287. RTC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RTC1_BOVIN

Accession

Primary (citable) accession number: Q2HJ88

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	March 21, 2006
Last modified:	September 1, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)