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Q2HJ88

- RTCA_BOVIN

UniProt

Q2HJ88 - RTCA_BOVIN

Protein

RNA 3'-terminal phosphate cyclase

Gene

RTCA

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing By similarity.By similarity

    Catalytic activityi

    ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei104 – 1041ATPBy similarity
    Active sitei320 – 3201Tele-AMP-histidine intermediateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi294 – 2985ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. RNA-3'-phosphate cyclase activity Source: UniProtKB-EC

    GO - Biological processi

    1. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA 3'-terminal phosphate cyclase (EC:6.5.1.4)
    Short name:
    RNA cyclase
    Short name:
    RNA-3'-phosphate cyclase
    Alternative name(s):
    RNA terminal phosphate cyclase domain-containing protein 1
    Gene namesi
    Name:RTCA
    Synonyms:RTCD1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 3

    Subcellular locationi

    Nucleusnucleoplasm By similarity

    GO - Cellular componenti

    1. nucleoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366RNA 3'-terminal phosphate cyclasePRO_0000288837Add
    BLAST

    Proteomic databases

    PRIDEiQ2HJ88.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000008293.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2HJ88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0430.
    GeneTreeiENSGT00530000063404.
    HOGENOMiHOG000015264.
    HOVERGENiHBG017761.
    InParanoidiQ2HJ88.
    KOiK01974.
    OMAiAEMLLRN.
    OrthoDBiEOG780RMG.
    TreeFamiTF300831.

    Family and domain databases

    Gene3Di3.30.360.20. 1 hit.
    3.65.10.20. 2 hits.
    InterProiIPR013791. RNA3'-term_phos_cycl_insert.
    IPR023797. RNA3'_phos_cyclase_dom.
    IPR000228. RNA3'_term_phos_cyc.
    IPR017770. RNA3'_term_phos_cyc_type_1.
    IPR020719. RNA3'_term_phos_cycl-like_CS.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    [Graphical view]
    PANTHERiPTHR11096. PTHR11096. 1 hit.
    PfamiPF01137. RTC. 1 hit.
    PF05189. RTC_insert. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005378. RNA3'_term_phos_cycl_euk. 1 hit.
    SUPFAMiSSF52913. SSF52913. 1 hit.
    SSF55205. SSF55205. 2 hits.
    TIGRFAMsiTIGR03399. RNA_3prim_cycl. 1 hit.
    PROSITEiPS01287. RTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2HJ88-1 [UniParc]FASTAAdd to Basket

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    MAGPRVEVDG GIMEGGGQIL RVSTALSCLL GLPLRVQKIR AGRSTPGLRP    50
    QHLSGLEMIR DLCDGQLEGA EIGSTEITFT PEKIKGGVHT ADTKTAGSVC 100
    LLMQVSMPCV LFAACPSELR LKGGTNAEMA PQIDYTAMVF KPIVEKFGFT 150
    FNCDIKMRGY YPKGGGEVIV RMSPVKQLSP INLTDRGCVT KIYGRAFVAG 200
    VLPFKVAKDM AAAAVRCIRK EIRDLYVNIQ PVQEPKDQAF GNGNGIIIIA 250
    ETSTGCLFAG SSLGKRGVNA DKVGIEAAEM LLANLRHGGA VDEYLQDQLI 300
    IFMALASGIS RIKTGPVTLH TQTAIHFAEQ LAKAKFTVKK SEDEEDASKD 350
    TYIIECQGIG MTNPNL 366
    Length:366
    Mass (Da):39,252
    Last modified:March 21, 2006 - v1
    Checksum:i417C040DBA122145
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC113251 mRNA. Translation: AAI13252.1.
    RefSeqiNP_001039520.1. NM_001046055.1.
    UniGeneiBt.20917.

    Genome annotation databases

    EnsembliENSBTAT00000008293; ENSBTAP00000008293; ENSBTAG00000006321.
    GeneIDi510469.
    KEGGibta:510469.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC113251 mRNA. Translation: AAI13252.1 .
    RefSeqi NP_001039520.1. NM_001046055.1.
    UniGenei Bt.20917.

    3D structure databases

    ProteinModelPortali Q2HJ88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000008293.

    Proteomic databases

    PRIDEi Q2HJ88.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000008293 ; ENSBTAP00000008293 ; ENSBTAG00000006321 .
    GeneIDi 510469.
    KEGGi bta:510469.

    Organism-specific databases

    CTDi 8634.

    Phylogenomic databases

    eggNOGi COG0430.
    GeneTreei ENSGT00530000063404.
    HOGENOMi HOG000015264.
    HOVERGENi HBG017761.
    InParanoidi Q2HJ88.
    KOi K01974.
    OMAi AEMLLRN.
    OrthoDBi EOG780RMG.
    TreeFami TF300831.

    Miscellaneous databases

    NextBioi 20869459.

    Family and domain databases

    Gene3Di 3.30.360.20. 1 hit.
    3.65.10.20. 2 hits.
    InterProi IPR013791. RNA3'-term_phos_cycl_insert.
    IPR023797. RNA3'_phos_cyclase_dom.
    IPR000228. RNA3'_term_phos_cyc.
    IPR017770. RNA3'_term_phos_cyc_type_1.
    IPR020719. RNA3'_term_phos_cycl-like_CS.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    [Graphical view ]
    PANTHERi PTHR11096. PTHR11096. 1 hit.
    Pfami PF01137. RTC. 1 hit.
    PF05189. RTC_insert. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005378. RNA3'_term_phos_cycl_euk. 1 hit.
    SUPFAMi SSF52913. SSF52913. 1 hit.
    SSF55205. SSF55205. 2 hits.
    TIGRFAMsi TIGR03399. RNA_3prim_cycl. 1 hit.
    PROSITEi PS01287. RTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Uterus.

    Entry informationi

    Entry nameiRTCA_BOVIN
    AccessioniPrimary (citable) accession number: Q2HJ88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3