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Q2HJ88

- RTCA_BOVIN

UniProt

Q2HJ88 - RTCA_BOVIN

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Protein

RNA 3'-terminal phosphate cyclase

Gene

RTCA

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).By similarity

Catalytic activityi

ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041ATPBy similarity
Active sitei320 – 3201Tele-AMP-histidine intermediateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi294 – 2985ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. poly(A) RNA binding Source: Ensembl
  3. RNA-3'-phosphate cyclase activity Source: UniProtKB-EC

GO - Biological processi

  1. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA 3'-terminal phosphate cyclase (EC:6.5.1.4)
Short name:
RNA cyclase
Short name:
RNA-3'-phosphate cyclase
Alternative name(s):
RNA terminal phosphate cyclase domain-containing protein 1
Gene namesi
Name:RTCA
Synonyms:RTCD1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 3

Subcellular locationi

Nucleusnucleoplasm By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366RNA 3'-terminal phosphate cyclasePRO_0000288837Add
BLAST

Proteomic databases

PRIDEiQ2HJ88.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008293.

Structurei

3D structure databases

ProteinModelPortaliQ2HJ88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0430.
GeneTreeiENSGT00530000063404.
HOGENOMiHOG000015264.
HOVERGENiHBG017761.
InParanoidiQ2HJ88.
KOiK01974.
OMAiAEMLLRN.
OrthoDBiEOG780RMG.
TreeFamiTF300831.

Family and domain databases

Gene3Di3.30.360.20. 1 hit.
3.65.10.20. 2 hits.
InterProiIPR013791. RNA3'-term_phos_cycl_insert.
IPR023797. RNA3'_phos_cyclase_dom.
IPR000228. RNA3'_term_phos_cyc.
IPR017770. RNA3'_term_phos_cyc_type_1.
IPR020719. RNA3'_term_phos_cycl-like_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
PANTHERiPTHR11096. PTHR11096. 1 hit.
PfamiPF01137. RTC. 1 hit.
PF05189. RTC_insert. 1 hit.
[Graphical view]
PIRSFiPIRSF005378. RNA3'_term_phos_cycl_euk. 1 hit.
SUPFAMiSSF52913. SSF52913. 1 hit.
SSF55205. SSF55205. 2 hits.
TIGRFAMsiTIGR03399. RNA_3prim_cycl. 1 hit.
PROSITEiPS01287. RTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2HJ88 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGPRVEVDG GIMEGGGQIL RVSTALSCLL GLPLRVQKIR AGRSTPGLRP
60 70 80 90 100
QHLSGLEMIR DLCDGQLEGA EIGSTEITFT PEKIKGGVHT ADTKTAGSVC
110 120 130 140 150
LLMQVSMPCV LFAACPSELR LKGGTNAEMA PQIDYTAMVF KPIVEKFGFT
160 170 180 190 200
FNCDIKMRGY YPKGGGEVIV RMSPVKQLSP INLTDRGCVT KIYGRAFVAG
210 220 230 240 250
VLPFKVAKDM AAAAVRCIRK EIRDLYVNIQ PVQEPKDQAF GNGNGIIIIA
260 270 280 290 300
ETSTGCLFAG SSLGKRGVNA DKVGIEAAEM LLANLRHGGA VDEYLQDQLI
310 320 330 340 350
IFMALASGIS RIKTGPVTLH TQTAIHFAEQ LAKAKFTVKK SEDEEDASKD
360
TYIIECQGIG MTNPNL
Length:366
Mass (Da):39,252
Last modified:March 21, 2006 - v1
Checksum:i417C040DBA122145
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC113251 mRNA. Translation: AAI13252.1.
RefSeqiNP_001039520.1. NM_001046055.1.
UniGeneiBt.20917.

Genome annotation databases

EnsembliENSBTAT00000008293; ENSBTAP00000008293; ENSBTAG00000006321.
GeneIDi510469.
KEGGibta:510469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC113251 mRNA. Translation: AAI13252.1 .
RefSeqi NP_001039520.1. NM_001046055.1.
UniGenei Bt.20917.

3D structure databases

ProteinModelPortali Q2HJ88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000008293.

Proteomic databases

PRIDEi Q2HJ88.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000008293 ; ENSBTAP00000008293 ; ENSBTAG00000006321 .
GeneIDi 510469.
KEGGi bta:510469.

Organism-specific databases

CTDi 8634.

Phylogenomic databases

eggNOGi COG0430.
GeneTreei ENSGT00530000063404.
HOGENOMi HOG000015264.
HOVERGENi HBG017761.
InParanoidi Q2HJ88.
KOi K01974.
OMAi AEMLLRN.
OrthoDBi EOG780RMG.
TreeFami TF300831.

Miscellaneous databases

NextBioi 20869459.

Family and domain databases

Gene3Di 3.30.360.20. 1 hit.
3.65.10.20. 2 hits.
InterProi IPR013791. RNA3'-term_phos_cycl_insert.
IPR023797. RNA3'_phos_cyclase_dom.
IPR000228. RNA3'_term_phos_cyc.
IPR017770. RNA3'_term_phos_cyc_type_1.
IPR020719. RNA3'_term_phos_cycl-like_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view ]
PANTHERi PTHR11096. PTHR11096. 1 hit.
Pfami PF01137. RTC. 1 hit.
PF05189. RTC_insert. 1 hit.
[Graphical view ]
PIRSFi PIRSF005378. RNA3'_term_phos_cycl_euk. 1 hit.
SUPFAMi SSF52913. SSF52913. 1 hit.
SSF55205. SSF55205. 2 hits.
TIGRFAMsi TIGR03399. RNA_3prim_cycl. 1 hit.
PROSITEi PS01287. RTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiRTCA_BOVIN
AccessioniPrimary (citable) accession number: Q2HJ88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 21, 2006
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3