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Protein

Glycine amidinotransferase, mitochondrial

Gene

GATM

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity).By similarity

Catalytic activityi

L-arginine + glycine = L-ornithine + guanidinoacetate.By similarity

Pathwayi: creatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes creatine from L-arginine and glycine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glycine amidinotransferase, mitochondrial (GATM)
  2. Guanidinoacetate N-methyltransferase (GAMT)
This subpathway is part of the pathway creatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes creatine from L-arginine and glycine, the pathway creatine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei254By similarity1
Active sitei303By similarity1
Active sitei407Amidino-cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-BTA-71288 Creatine metabolism
UniPathwayiUPA00104; UER00579

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine amidinotransferase, mitochondrial (EC:2.1.4.1By similarity)
Alternative name(s):
L-arginine:glycine amidinotransferase
Transamidinase
Gene namesi
Name:GATM
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:29274 GATM

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 37MitochondrionBy similarityAdd BLAST37
ChainiPRO_000028694038 – 423Glycine amidinotransferase, mitochondrialAdd BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46PhosphoserineBy similarity1
Modified residuei49PhosphoserineBy similarity1
Modified residuei385N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ2HJ74
PeptideAtlasiQ2HJ74
PRIDEiQ2HJ74

Expressioni

Gene expression databases

BgeeiENSBTAG00000005586

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007338

Structurei

3D structure databases

ProteinModelPortaliQ2HJ74
SMRiQ2HJ74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amidinotransferase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IFBR Eukaryota
ENOG410Y45M LUCA
GeneTreeiENSGT00390000011613
HOGENOMiHOG000231593
HOVERGENiHBG002492
InParanoidiQ2HJ74
KOiK00613
OMAiRPCHQID
OrthoDBiEOG091G07LX
TreeFamiTF300256

Family and domain databases

InterProiView protein in InterPro
IPR033195 AmidinoTrfase
PANTHERiPTHR10488 PTHR10488, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2HJ74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVRCLRGG SRGAEALHYI GSRLGRTVTG WVQRTFQSTQ AATASSRNSC
60 70 80 90 100
AADDKATDPL PKDCPVSSFN EWDPLEEVIV GRAENACVPP FTVEVKANTY
110 120 130 140 150
DKHWPFYQKY GGSYFPKDHL QKAVAEIEEM CNILKMEGVT VRRPDPIDWS
160 170 180 190 200
LKYKTPDFES TGLYGAMPRD ILIVVGNEII EAPMAWRARF FEYRAYRTII
210 220 230 240 250
KDYFRRGAKW TTAPKPTMAD ELYDQDYPIH SVEDRHKLAA QGKFVTTEFE
260 270 280 290 300
PCFDAADFIR AGRDIFVQRS QVTNYMGIEW MRKHLAPDYR VHIVSFKDPN
310 320 330 340 350
PMHIDATFNI IGPGLVLSNP DRPCHQIDLF KKAGWTIVTP PTPIIPDDHP
360 370 380 390 400
LWMSSKWLSM NVLMLDEKRV MVDANEVPIQ KMFEKLGIST IKVSIRNANS
410 420
LGGGFHCWTC DVRRRGTLQS YFD
Length:423
Mass (Da):48,357
Last modified:March 21, 2006 - v1
Checksum:iA330454DB84EE5BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113272 mRNA Translation: AAI13273.1
RefSeqiNP_001039343.1, NM_001045878.1
UniGeneiBt.30785

Genome annotation databases

EnsembliENSBTAT00000007338; ENSBTAP00000007338; ENSBTAG00000005586
GeneIDi414732
KEGGibta:414732

Similar proteinsi

Entry informationi

Entry nameiGATM_BOVIN
AccessioniPrimary (citable) accession number: Q2HJ74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health