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Protein

3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

Gene

HIBCH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity).By similarity

Catalytic activityi

3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate.

Pathwayi: L-valine degradation

This protein is involved in the pathway L-valine degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway L-valine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211SubstrateBy similarity
Binding sitei146 – 1461Substrate; via amide nitrogenBy similarity
Binding sitei169 – 1691SubstrateBy similarity
Binding sitei177 – 1771SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Branched-chain amino acid catabolism

Enzyme and pathway databases

UniPathwayiUPA00362.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC:3.1.2.4)
Alternative name(s):
3-hydroxyisobutyryl-coenzyme A hydrolase
Short name:
HIB-CoA hydrolase
Short name:
HIBYL-CoA-H
Gene namesi
Name:HIBCH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3232MitochondrionBy similarityAdd
BLAST
Chaini33 – 3863543-hydroxyisobutyryl-CoA hydrolase, mitochondrialPRO_0000284928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei92 – 921N6-acetyllysine; alternateBy similarity
Modified residuei92 – 921N6-succinyllysine; alternateBy similarity
Modified residuei221 – 2211N6-acetyllysine; alternateBy similarity
Modified residuei221 – 2211N6-succinyllysine; alternateBy similarity
Modified residuei234 – 2341PhosphoserineBy similarity
Modified residuei250 – 2501N6-succinyllysineBy similarity
Modified residuei257 – 2571N6-succinyllysineBy similarity
Modified residuei297 – 2971N6-acetyllysine; alternateBy similarity
Modified residuei297 – 2971N6-succinyllysine; alternateBy similarity
Modified residuei301 – 3011N6-succinyllysineBy similarity
Modified residuei353 – 3531N6-acetyllysine; alternateBy similarity
Modified residuei353 – 3531N6-succinyllysine; alternateBy similarity
Modified residuei356 – 3561PhosphoserineBy similarity
Modified residuei360 – 3601N6-acetyllysineBy similarity
Modified residuei365 – 3651N6-acetyllysineBy similarity
Modified residuei377 – 3771N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PeptideAtlasiQ2HJ73.
PRIDEiQ2HJ73.

Structurei

3D structure databases

ProteinModelPortaliQ2HJ73.
SMRiQ2HJ73. Positions 32-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000217005.
HOVERGENiHBG054809.
InParanoidiQ2HJ73.
KOiK05605.

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
IPR032259. HIBYL-CoA-H.
[Graphical view]
PfamiPF16113. ECH_2. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2HJ73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLQGLCRLM SRFNSYKRTN IILQHLKMSN HTDAAAEVLL ERKGCAGVIT
60 70 80 90 100
LNRPRFLNTL TLGMIRQIYA QLKKWEQDPK TFLIIIKGAG EKAFCAGGDI
110 120 130 140 150
RALSEARNTN QKMLQDLFRE EYILNNAIDS CQKPYIALIH GITMGGGVGV
160 170 180 190 200
SVHGQFRVAT EKSVFAMPET AIGLFPDVGG GYFLPRLQGK LGYFLALTGF
210 220 230 240 250
RLKGRDVYTA GIATHFVDFE KLGMLEEDLL ALKSPSKENI ADVLETYHAK
260 270 280 290 300
SKTDQDKPFI LEEHMDKINS WFSANTVEQI VDNLQQDGSS FALEQLKVIK
310 320 330 340 350
KMSPTSLKIT LRQLMEGSSK TLPEVLIMEY RLSQACMKGH DFHEGVRAVL
360 370 380
IDKDQSPKWK PADLKEVTDE DLNDYFKSLG SNDLKF
Length:386
Mass (Da):43,349
Last modified:March 21, 2006 - v1
Checksum:i3920F7D82D6CBB09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113274 mRNA. Translation: AAI13275.1.
RefSeqiXP_010800133.1. XM_010801831.1.
XP_015317723.1. XM_015462237.1.
UniGeneiBt.56752.

Genome annotation databases

GeneIDi535883.
KEGGibta:535883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113274 mRNA. Translation: AAI13275.1.
RefSeqiXP_010800133.1. XM_010801831.1.
XP_015317723.1. XM_015462237.1.
UniGeneiBt.56752.

3D structure databases

ProteinModelPortaliQ2HJ73.
SMRiQ2HJ73. Positions 32-386.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ2HJ73.
PRIDEiQ2HJ73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi535883.
KEGGibta:535883.

Organism-specific databases

CTDi26275.

Phylogenomic databases

HOGENOMiHOG000217005.
HOVERGENiHBG054809.
InParanoidiQ2HJ73.
KOiK05605.

Enzyme and pathway databases

UniPathwayiUPA00362.

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
IPR032259. HIBYL-CoA-H.
[Graphical view]
PfamiPF16113. ECH_2. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiHIBCH_BOVIN
AccessioniPrimary (citable) accession number: Q2HJ73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 21, 2006
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.