Reviewed, UniProtKB/Swiss-Prot Q2HJ67 (HXA5_BOVIN)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A5

Gene names

Name:

HOXA5

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Homeobox protein Hox-A5		PRO_0000246003
Regions
	DNA binding	195 – 254	60	Homeobox
	Motif	176 – 181	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	Q2HJ67-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: AF30B3A54EB2377A	FASTA	270	29,253
	10 20 30 40 50 60 MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN GMDLSVGRSG 70 80 90 100 110 120 SGHFGSGERA RSYAAGASAA PAEPRYSQPA TSTHSPPPDP LPCSAVAPSP GSDSHHGGKN 130 140 150 160 170 180 SLGNSSGASA NAGSTHISSR EGVGTASGAE EDAPASSEQA SAQSEPSPAP PAQPQIYPWM 190 200 210 220 230 240 RKLHISHDNI GGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK 250 260 270 IWFQNRRMKW KKDNKLKSMS MAAAGGAFRP

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Uterus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC113284 mRNA. Translation: AAI13285.1.
IPI	IPI00711374.
RefSeq	NP_001070566.1.
UniGene	Bt.11342
3D structure databases
SMR	Q2HJ67. Positions 196-257.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2HJ67.
Genome annotation databases
Ensembl	ENSBTAT00000016196; ENSBTAP00000016196; ENSBTAG00000012211; Bos taurus. [Genome view]
GeneID	768039.
KEGG	bta:768039.
Organism-specific databases
CTD	768039.
Phylogenomic databases
HOVERGEN	Q2HJ67.
OrthoDB	EOG9PCDB9
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA5_BOVIN

Accession

Primary (citable) accession number: Q2HJ67

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	March 21, 2006
Last modified:	November 24, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)