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Protein

Homeobox protein Hox-A5

Gene

HOXA5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi195 – 254HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A5
Gene namesi
Name:HOXA5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Organism-specific databases

VGNCiVGNC:29913 HOXA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002460031 – 270Homeobox protein Hox-A5Add BLAST270

Proteomic databases

PaxDbiQ2HJ67
PRIDEiQ2HJ67

Expressioni

Gene expression databases

BgeeiENSBTAG00000012211

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016196

Structurei

3D structure databases

ProteinModelPortaliQ2HJ67
SMRiQ2HJ67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi176 – 181Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231178
HOVERGENiHBG016849
InParanoidiQ2HJ67
KOiK09305
OMAiLKSMNMA
OrthoDBiEOG091G09XD
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2HJ67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN
60 70 80 90 100
GMDLSVGRSG SGHFGSGERA RSYAAGASAA PAEPRYSQPA TSTHSPPPDP
110 120 130 140 150
LPCSAVAPSP GSDSHHGGKN SLGNSSGASA NAGSTHISSR EGVGTASGAE
160 170 180 190 200
EDAPASSEQA SAQSEPSPAP PAQPQIYPWM RKLHISHDNI GGPEGKRART
210 220 230 240 250
AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK IWFQNRRMKW
260 270
KKDNKLKSMS MAAAGGAFRP
Length:270
Mass (Da):29,253
Last modified:March 21, 2006 - v1
Checksum:iAF30B3A54EB2377A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113284 mRNA Translation: AAI13285.1
RefSeqiNP_001070566.1, NM_001077098.1
UniGeneiBt.11342

Genome annotation databases

EnsembliENSBTAT00000016196; ENSBTAP00000016196; ENSBTAG00000012211
GeneIDi768039
KEGGibta:768039

Similar proteinsi

Entry informationi

Entry nameiHXA5_BOVIN
AccessioniPrimary (citable) accession number: Q2HJ67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome