Q2HJ67 (HXA5_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A5

Gene names

Name:

HOXA5

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara bronchiole development Inferred from electronic annotation. Source: Compara cell migration Inferred from electronic annotation. Source: Compara cell-cell signaling involved in mammary gland development Inferred from electronic annotation. Source: Compara embryonic skeletal system morphogenesis Inferred from electronic annotation. Source: Compara epithelial tube branching involved in lung morphogenesis Inferred from electronic annotation. Source: Compara intestinal epithelial cell maturation Inferred from electronic annotation. Source: Compara lung alveolus development Inferred from electronic annotation. Source: Compara lung goblet cell differentiation Inferred from electronic annotation. Source: Compara lung-associated mesenchyme development Inferred from electronic annotation. Source: Compara mammary gland alveolus development Inferred from electronic annotation. Source: Compara mammary gland epithelial cell differentiation Inferred from electronic annotation. Source: Compara mesenchymal-epithelial cell signaling Inferred from electronic annotation. Source: Compara multicellular organism growth Inferred from electronic annotation. Source: Compara negative regulation of angiogenesis Inferred from electronic annotation. Source: Compara negative regulation of erythrocyte differentiation Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of myeloid cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of receptor biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara regulation of mammary gland epithelial cell proliferation Inferred from electronic annotation. Source: Compara respiratory system process Inferred from electronic annotation. Source: Compara thyroid gland development Inferred from electronic annotation. Source: Compara trachea cartilage morphogenesis Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Homeobox protein Hox-A5		PRO_0000246003
Regions
	DNA binding	195 – 254	60	Homeobox
	Motif	176 – 181	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	Q2HJ67 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: AF30B3A54EB2377A	FASTA	270	29,253
	10 20 30 40 50 60 MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN GMDLSVGRSG 70 80 90 100 110 120 SGHFGSGERA RSYAAGASAA PAEPRYSQPA TSTHSPPPDP LPCSAVAPSP GSDSHHGGKN 130 140 150 160 170 180 SLGNSSGASA NAGSTHISSR EGVGTASGAE EDAPASSEQA SAQSEPSPAP PAQPQIYPWM 190 200 210 220 230 240 RKLHISHDNI GGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK 250 260 270 IWFQNRRMKW KKDNKLKSMS MAAAGGAFRP

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Uterus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC113284 mRNA. Translation: AAI13285.1.
IPI	IPI00711374.
RefSeq	NP_001070566.1. NM_001077098.1.
UniGene	Bt.11342.
3D structure databases
ProteinModelPortal	Q2HJ67.
SMR	Q2HJ67. Positions 174-255.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000016196.
Proteomic databases
PRIDE	Q2HJ67.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000016196; ENSBTAP00000016196; ENSBTAG00000012211.
GeneID	768039.
KEGG	bta:768039.
Organism-specific databases
CTD	3202.
Phylogenomic databases
eggNOG	NOG236516.
GeneTree	ENSGT00700000104189.
HOGENOM	HOG000231178.
HOVERGEN	HBG016849.
InParanoid	Q2HJ67.
KO	K09305.
OMA	YRDSASM.
OrthoDB	EOG49S677.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20918394.

Entry information

Entry name

HXA5_BOVIN

Accession

Primary (citable) accession number: Q2HJ67

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	March 21, 2006
Last modified:	April 3, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program