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Q2HJ67

- HXA5_BOVIN

UniProt

Q2HJ67 - HXA5_BOVIN

Protein

Homeobox protein Hox-A5

Gene

HOXA5

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi195 – 25460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. bronchiole development Source: Ensembl
    3. cell-cell signaling involved in mammary gland development Source: Ensembl
    4. cell migration Source: Ensembl
    5. embryonic skeletal system morphogenesis Source: Ensembl
    6. epithelial tube branching involved in lung morphogenesis Source: Ensembl
    7. intestinal epithelial cell maturation Source: Ensembl
    8. lung alveolus development Source: Ensembl
    9. lung-associated mesenchyme development Source: Ensembl
    10. lung goblet cell differentiation Source: Ensembl
    11. mammary gland alveolus development Source: Ensembl
    12. mammary gland epithelial cell differentiation Source: Ensembl
    13. mesenchymal-epithelial cell signaling Source: Ensembl
    14. multicellular organism growth Source: Ensembl
    15. negative regulation of angiogenesis Source: Ensembl
    16. negative regulation of erythrocyte differentiation Source: Ensembl
    17. positive regulation of apoptotic process Source: Ensembl
    18. positive regulation of myeloid cell differentiation Source: Ensembl
    19. positive regulation of receptor biosynthetic process Source: Ensembl
    20. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    21. regulation of mammary gland epithelial cell proliferation Source: Ensembl
    22. respiratory system process Source: Ensembl
    23. thyroid gland development Source: Ensembl
    24. trachea cartilage morphogenesis Source: Ensembl
    25. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A5
    Gene namesi
    Name:HOXA5
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 4

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Homeobox protein Hox-A5PRO_0000246003Add
    BLAST

    Proteomic databases

    PRIDEiQ2HJ67.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000016196.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2HJ67.
    SMRiQ2HJ67. Positions 174-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi176 – 1816Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG236516.
    GeneTreeiENSGT00750000117269.
    HOGENOMiHOG000231178.
    HOVERGENiHBG016849.
    InParanoidiQ2HJ67.
    KOiK09305.
    OMAiSVSEQYR.
    OrthoDBiEOG780RP4.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2HJ67-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN    50
    GMDLSVGRSG SGHFGSGERA RSYAAGASAA PAEPRYSQPA TSTHSPPPDP 100
    LPCSAVAPSP GSDSHHGGKN SLGNSSGASA NAGSTHISSR EGVGTASGAE 150
    EDAPASSEQA SAQSEPSPAP PAQPQIYPWM RKLHISHDNI GGPEGKRART 200
    AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK IWFQNRRMKW 250
    KKDNKLKSMS MAAAGGAFRP 270
    Length:270
    Mass (Da):29,253
    Last modified:March 21, 2006 - v1
    Checksum:iAF30B3A54EB2377A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC113284 mRNA. Translation: AAI13285.1.
    RefSeqiNP_001070566.1. NM_001077098.1.
    UniGeneiBt.11342.

    Genome annotation databases

    EnsembliENSBTAT00000016196; ENSBTAP00000016196; ENSBTAG00000012211.
    GeneIDi768039.
    KEGGibta:768039.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC113284 mRNA. Translation: AAI13285.1 .
    RefSeqi NP_001070566.1. NM_001077098.1.
    UniGenei Bt.11342.

    3D structure databases

    ProteinModelPortali Q2HJ67.
    SMRi Q2HJ67. Positions 174-255.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000016196.

    Proteomic databases

    PRIDEi Q2HJ67.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000016196 ; ENSBTAP00000016196 ; ENSBTAG00000012211 .
    GeneIDi 768039.
    KEGGi bta:768039.

    Organism-specific databases

    CTDi 3202.

    Phylogenomic databases

    eggNOGi NOG236516.
    GeneTreei ENSGT00750000117269.
    HOGENOMi HOG000231178.
    HOVERGENi HBG016849.
    InParanoidi Q2HJ67.
    KOi K09305.
    OMAi SVSEQYR.
    OrthoDBi EOG780RP4.
    TreeFami TF316310.

    Miscellaneous databases

    NextBioi 20918394.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Uterus.

    Entry informationi

    Entry nameiHXA5_BOVIN
    AccessioniPrimary (citable) accession number: Q2HJ67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3