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Protein

Homeobox protein Hox-A5

Gene

HOXA5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi195 – 25460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. bronchiole development Source: Ensembl
  3. cell-cell signaling involved in mammary gland development Source: Ensembl
  4. cell migration Source: Ensembl
  5. embryonic skeletal system morphogenesis Source: Ensembl
  6. epithelial tube branching involved in lung morphogenesis Source: Ensembl
  7. intestinal epithelial cell maturation Source: Ensembl
  8. lung alveolus development Source: Ensembl
  9. lung-associated mesenchyme development Source: Ensembl
  10. lung goblet cell differentiation Source: Ensembl
  11. mammary gland alveolus development Source: Ensembl
  12. mammary gland epithelial cell differentiation Source: Ensembl
  13. mesenchymal-epithelial cell signaling Source: Ensembl
  14. multicellular organism growth Source: Ensembl
  15. negative regulation of angiogenesis Source: Ensembl
  16. negative regulation of erythrocyte differentiation Source: Ensembl
  17. positive regulation of apoptotic process Source: Ensembl
  18. positive regulation of myeloid cell differentiation Source: Ensembl
  19. positive regulation of receptor biosynthetic process Source: Ensembl
  20. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  21. regulation of mammary gland epithelial cell proliferation Source: Ensembl
  22. respiratory system process Source: Ensembl
  23. thyroid gland development Source: Ensembl
  24. trachea cartilage morphogenesis Source: Ensembl
  25. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A5
Gene namesi
Name:HOXA5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 4

Subcellular locationi

  1. Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Homeobox protein Hox-A5PRO_0000246003Add
BLAST

Proteomic databases

PRIDEiQ2HJ67.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016196.

Structurei

3D structure databases

ProteinModelPortaliQ2HJ67.
SMRiQ2HJ67. Positions 174-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi176 – 1816Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG236516.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiQ2HJ67.
KOiK09305.
OMAiYRDSASM.
OrthoDBiEOG780RP4.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2HJ67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN
60 70 80 90 100
GMDLSVGRSG SGHFGSGERA RSYAAGASAA PAEPRYSQPA TSTHSPPPDP
110 120 130 140 150
LPCSAVAPSP GSDSHHGGKN SLGNSSGASA NAGSTHISSR EGVGTASGAE
160 170 180 190 200
EDAPASSEQA SAQSEPSPAP PAQPQIYPWM RKLHISHDNI GGPEGKRART
210 220 230 240 250
AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK IWFQNRRMKW
260 270
KKDNKLKSMS MAAAGGAFRP
Length:270
Mass (Da):29,253
Last modified:March 21, 2006 - v1
Checksum:iAF30B3A54EB2377A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113284 mRNA. Translation: AAI13285.1.
RefSeqiNP_001070566.1. NM_001077098.1.
UniGeneiBt.11342.

Genome annotation databases

EnsembliENSBTAT00000016196; ENSBTAP00000016196; ENSBTAG00000012211.
GeneIDi768039.
KEGGibta:768039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113284 mRNA. Translation: AAI13285.1.
RefSeqiNP_001070566.1. NM_001077098.1.
UniGeneiBt.11342.

3D structure databases

ProteinModelPortaliQ2HJ67.
SMRiQ2HJ67. Positions 174-255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016196.

Proteomic databases

PRIDEiQ2HJ67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016196; ENSBTAP00000016196; ENSBTAG00000012211.
GeneIDi768039.
KEGGibta:768039.

Organism-specific databases

CTDi3202.

Phylogenomic databases

eggNOGiNOG236516.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiQ2HJ67.
KOiK09305.
OMAiYRDSASM.
OrthoDBiEOG780RP4.
TreeFamiTF316310.

Miscellaneous databases

NextBioi20918394.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiHXA5_BOVIN
AccessioniPrimary (citable) accession number: Q2HJ67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 21, 2006
Last modified: January 7, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.