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Protein

Gap junction gamma-1 protein

Gene

GJC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-112303 Electric Transmission Across Gap Junctions
R-BTA-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-1 protein
Alternative name(s):
Gap junction alpha-7 protein
Gene namesi
Name:GJC1
Synonyms:GJA7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:29382 GJC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 45HelicalSequence analysisAdd BLAST23
Topological domaini46 – 75ExtracellularSequence analysisAdd BLAST30
Transmembranei76 – 95HelicalSequence analysisAdd BLAST20
Topological domaini96 – 175CytoplasmicSequence analysisAdd BLAST80
Transmembranei176 – 198HelicalSequence analysisAdd BLAST23
Topological domaini199 – 228ExtracellularSequence analysisAdd BLAST30
Transmembranei229 – 248HelicalSequence analysisAdd BLAST20
Topological domaini249 – 396CytoplasmicSequence analysisAdd BLAST148

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002448771 – 396Gap junction gamma-1 proteinAdd BLAST396

Proteomic databases

PaxDbiQ2HJ66
PRIDEiQ2HJ66

Expressioni

Gene expression databases

BgeeiENSBTAG00000004036

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005277

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFK3 Eukaryota
ENOG410Z7PN LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231126
HOVERGENiHBG009576
InParanoidiQ2HJ66
KOiK07616
OMAiIMYGVSC
OrthoDBiEOG091G08B8
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002265 Connexin45
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01136 CONNEXINA6
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2HJ66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK
60 70 80 90 100
FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA
110 120 130 140 150
KMEHGDADKK AARSKPYAMR WKQHRALEET EEDHEEDPMM YPEMELESEK
160 170 180 190 200
ENKDQNQSKP KHDGRRRIRE DGLMKIYVLQ LLARTVFEVG FLVGQYFLYG
210 220 230 240 250
FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG LCLLLNIWEM
260 270 280 290 300
LHLGFGTIRD SLNSKRRELE DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ
310 320 330 340 350
YTELSNAKIA YKQNKANIAQ EQQYGSHEDN LPPDLETLQR EIRMAQERLD
360 370 380 390
LAIQAYNHQN NPHGSREKKA KVGSKAGSNK SSASSKSGDG KTSVWI
Length:396
Mass (Da):45,553
Last modified:March 21, 2006 - v1
Checksum:iC3BE7424F9AFB489
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113285 mRNA Translation: AAI13286.1
RefSeqiNP_001039541.1, NM_001046076.1
XP_005220906.1, XM_005220849.3
XP_005220907.1, XM_005220850.3
XP_005220908.1, XM_005220851.3
XP_010814634.1, XM_010816332.2
XP_010814635.1, XM_010816333.2
XP_015314351.1, XM_015458865.1
UniGeneiBt.26012

Genome annotation databases

EnsembliENSBTAT00000005277; ENSBTAP00000005277; ENSBTAG00000004036
GeneIDi511119
KEGGibta:511119

Similar proteinsi

Entry informationi

Entry nameiCXG1_BOVIN
AccessioniPrimary (citable) accession number: Q2HJ66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health