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Protein

Gap junction gamma-1 protein

Gene

GJC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-112303. Electric Transmission Across Gap Junctions.
R-BTA-190861. Gap junction assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-1 protein
Alternative name(s):
Gap junction alpha-7 protein
Gene namesi
Name:GJC1
Synonyms:GJA7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence analysisAdd
BLAST
Transmembranei23 – 4523HelicalSequence analysisAdd
BLAST
Topological domaini46 – 7530ExtracellularSequence analysisAdd
BLAST
Transmembranei76 – 9520HelicalSequence analysisAdd
BLAST
Topological domaini96 – 17580CytoplasmicSequence analysisAdd
BLAST
Transmembranei176 – 19823HelicalSequence analysisAdd
BLAST
Topological domaini199 – 22830ExtracellularSequence analysisAdd
BLAST
Transmembranei229 – 24820HelicalSequence analysisAdd
BLAST
Topological domaini249 – 396148CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Gap junction gamma-1 proteinPRO_0000244877Add
BLAST

Proteomic databases

PaxDbiQ2HJ66.
PRIDEiQ2HJ66.

Expressioni

Gene expression databases

BgeeiENSBTAG00000004036.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005277.

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFK3. Eukaryota.
ENOG410Z7PN. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231126.
HOVERGENiHBG009576.
InParanoidiQ2HJ66.
KOiK07616.
OMAiRWKQHRG.
OrthoDBiEOG091G08B8.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002265. Connexin45.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01136. CONNEXINA6.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2HJ66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK
60 70 80 90 100
FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA
110 120 130 140 150
KMEHGDADKK AARSKPYAMR WKQHRALEET EEDHEEDPMM YPEMELESEK
160 170 180 190 200
ENKDQNQSKP KHDGRRRIRE DGLMKIYVLQ LLARTVFEVG FLVGQYFLYG
210 220 230 240 250
FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG LCLLLNIWEM
260 270 280 290 300
LHLGFGTIRD SLNSKRRELE DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ
310 320 330 340 350
YTELSNAKIA YKQNKANIAQ EQQYGSHEDN LPPDLETLQR EIRMAQERLD
360 370 380 390
LAIQAYNHQN NPHGSREKKA KVGSKAGSNK SSASSKSGDG KTSVWI
Length:396
Mass (Da):45,553
Last modified:March 21, 2006 - v1
Checksum:iC3BE7424F9AFB489
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113285 mRNA. Translation: AAI13286.1.
RefSeqiNP_001039541.1. NM_001046076.1.
XP_005220906.1. XM_005220849.3.
XP_005220907.1. XM_005220850.3.
XP_005220908.1. XM_005220851.3.
XP_010814634.1. XM_010816332.2.
XP_010814635.1. XM_010816333.2.
XP_015314351.1. XM_015458865.1.
UniGeneiBt.26012.

Genome annotation databases

EnsembliENSBTAT00000005277; ENSBTAP00000005277; ENSBTAG00000004036.
GeneIDi511119.
KEGGibta:511119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113285 mRNA. Translation: AAI13286.1.
RefSeqiNP_001039541.1. NM_001046076.1.
XP_005220906.1. XM_005220849.3.
XP_005220907.1. XM_005220850.3.
XP_005220908.1. XM_005220851.3.
XP_010814634.1. XM_010816332.2.
XP_010814635.1. XM_010816333.2.
XP_015314351.1. XM_015458865.1.
UniGeneiBt.26012.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005277.

Proteomic databases

PaxDbiQ2HJ66.
PRIDEiQ2HJ66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005277; ENSBTAP00000005277; ENSBTAG00000004036.
GeneIDi511119.
KEGGibta:511119.

Organism-specific databases

CTDi10052.

Phylogenomic databases

eggNOGiENOG410IFK3. Eukaryota.
ENOG410Z7PN. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231126.
HOVERGENiHBG009576.
InParanoidiQ2HJ66.
KOiK07616.
OMAiRWKQHRG.
OrthoDBiEOG091G08B8.
TreeFamiTF329606.

Enzyme and pathway databases

ReactomeiR-BTA-112303. Electric Transmission Across Gap Junctions.
R-BTA-190861. Gap junction assembly.

Gene expression databases

BgeeiENSBTAG00000004036.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002265. Connexin45.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01136. CONNEXINA6.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXG1_BOVIN
AccessioniPrimary (citable) accession number: Q2HJ66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 21, 2006
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.