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Q2HJ61 (LPP2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lipid phosphate phosphohydrolase 2
EC=3.1.3.4
Alternative name(s):
PAP2-gamma
Short name=PAP2-G
Phosphatidate phosphohydrolase type 2c
Phosphatidic acid phosphatase 2c
Short name=PAP-2c
Short name=PAP2c
Gene names
Name:PPAP2C
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P) By similarity.

Catalytic activity

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

Subunit structure

Homodimer By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionphosphatidate phosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287Lipid phosphate phosphohydrolase 2
PRO_0000286941

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane52 – 7221Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane162 – 18221Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane226 – 24621Helical; Potential

Amino acid modifications

Glycosylation1391N-linked (GlcNAc...) Potential
Glycosylation1551N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q2HJ61 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: C827568CC1C5C2D2

FASTA28732,328
        10         20         30         40         50         60 
MERRWVFVLL DVLCVLVAAL PCAILTFVNT PYKRGFYCGD DSIRYPYRPD TITHGLMAGV 

        70         80         90        100        110        120 
IITATVILVS AGEAYLVYTD RLYSRSDFNN YLAALYKVVG TFLFGAAVSQ SLTDLAKYMT 

       130        140        150        160        170        180 
GRLRPNFLAV CDPDWSRVNC SAYVQVEVCR GSSANVTESR LSFYSGHSSF GMYCMVFLAL 

       190        200        210        220        230        240 
YVQARLCWKW ARLLRPTVQF FLVAFALYVG YTRVSDHKHH WSDVLVGLLQ GALVASLTVR 

       250        260        270        280 
YISDFFKARP PQHCPEEEDL ERKPSLSLTL ALGETDCNHY GYPVSSS

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC113292 mRNA. Translation: AAI13293.1.
IPIIPI00714730.
RefSeqNP_001039355.1. NM_001045890.1.
UniGeneBt.52380.

3D structure databases

ProteinModelPortalQ2HJ61.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2HJ61.

Proteomic databases

PRIDEQ2HJ61.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000000955; ENSBTAP00000000955; ENSBTAG00000000717.
GeneID504545.
KEGGbta:504545.

Organism-specific databases

CTD8612.

Phylogenomic databases

eggNOGmaNOG09199.
GeneTreeENSGT00550000074203.
HOVERGENHBG002048.
InParanoidQ2HJ61.
OMACRGSPAN.
OrthoDBEOG43FGXK.
PhylomeDBQ2HJ61.

Family and domain databases

InterProIPR016118. P_Acid_Pase/Cl_peroxidase_N.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
Gene3DG3DSA:1.20.144.10. P_Acid_Pase/Cl_peroxidase_N. 1 hit.
KOK01080.
PfamPF01569. PAP2. 1 hit.
[Graphical view]
SMARTSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMSSF48317. AcPase_VanPerase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPP2_BOVIN
AccessionPrimary (citable) accession number: Q2HJ61
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 21, 2006
Last modified: November 16, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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