Reviewed, UniProtKB/Swiss-Prot Q2HJ61 (LPP2_BOVIN)

Names and origin

Protein names

Recommended name:
    Lipid phosphate phosphohydrolase 2
    EC=3.1.3.4
Alternative name(s):
    Phosphatidic acid phosphatase 2c
      Short name=PAP-2c
      Short name=PAP2c
    Phosphatidate phosphohydrolase type 2c
    PAP2-gamma
      Short name=PAP2-G

Gene names

Name:

PPAP2C

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P) By similarity.
Catalytic activity	A 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Subunit structure	Homodimer By similarity.
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 287	287	Lipid phosphate phosphohydrolase 2		PRO_0000286941
Regions
	Transmembrane	5 – 25	21	Potential
	Transmembrane	52 – 72	21	Potential
	Transmembrane	88 – 108	21	Potential
	Transmembrane	162 – 182	21	Potential
	Transmembrane	196 – 216	21	Potential
	Transmembrane	226 – 246	21	Potential
Amino acid modifications
	Glycosylation	139	1	N-linked (GlcNAc...) Potential
	Glycosylation	155	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2HJ61-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: C827568CC1C5C2D2	FASTA	287	32,328
	10 20 30 40 50 60 MERRWVFVLL DVLCVLVAAL PCAILTFVNT PYKRGFYCGD DSIRYPYRPD TITHGLMAGV 70 80 90 100 110 120 IITATVILVS AGEAYLVYTD RLYSRSDFNN YLAALYKVVG TFLFGAAVSQ SLTDLAKYMT 130 140 150 160 170 180 GRLRPNFLAV CDPDWSRVNC SAYVQVEVCR GSSANVTESR LSFYSGHSSF GMYCMVFLAL 190 200 210 220 230 240 YVQARLCWKW ARLLRPTVQF FLVAFALYVG YTRVSDHKHH WSDVLVGLLQ GALVASLTVR 250 260 270 280 YISDFFKARP PQHCPEEEDL ERKPSLSLTL ALGETDCNHY GYPVSSS

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Uterus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC113292 mRNA. Translation: AAI13293.1.
IPI	IPI00714730.
RefSeq	NP_001039355.1.
UniGene	Bt.52380
3D structure databases
SMR	Q2HJ61. Positions 94-250.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2HJ61.
Genome annotation databases
Ensembl	ENSBTAT00000000955; ENSBTAP00000000955; ENSBTAG00000000717; Bos taurus. [Genome view]
GeneID	504545.
KEGG	bta:504545.
Organism-specific databases
CTD	504545.
Phylogenomic databases
eggNOG	maNOG09199.
HOVERGEN	Q2HJ61.
InParanoid	Q2HJ61.
OMA	WKWARLL.
OrthoDB	EOG93R66R.
PhylomeDB	Q2HJ61.
Enzyme and pathway databases
BRENDA	3.1.3.4. 251.
Family and domain databases
InterPro	IPR016118. P_Acid_Pase/Cl_peroxidase_N. IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Gene3D	G3DSA:1.20.144.10. P_Acid_Pase/Cl_peroxidase_N. 1 hit.
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPP2_BOVIN

Accession

Primary (citable) accession number: Q2HJ61

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	March 21, 2006
Last modified:	January 19, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)