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Q2HJ58

- PRPS1_BOVIN

UniProt

Q2HJ58 - PRPS1_BOVIN

Protein

Ribose-phosphate pyrophosphokinase 1

Gene

PRPS1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

    Catalytic activityi

    ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by magnesium and inorganic phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi128 – 1281MagnesiumSequence Analysis
    Metal bindingi130 – 1301MagnesiumSequence Analysis
    Binding sitei130 – 1301ATPBy similarity
    Metal bindingi139 – 1391MagnesiumSequence Analysis
    Metal bindingi143 – 1431MagnesiumSequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi96 – 1016ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. kinase activity Source: UniProtKB-KW
    3. magnesium ion binding Source: InterPro
    4. protein homodimerization activity Source: UniProtKB
    5. ribose phosphate diphosphokinase activity Source: UniProtKB

    GO - Biological processi

    1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. hypoxanthine biosynthetic process Source: Ensembl
    3. nervous system development Source: Ensembl
    4. purine nucleotide biosynthetic process Source: Ensembl
    5. ribonucleoside monophosphate biosynthetic process Source: InterPro
    6. urate biosynthetic process Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_205661. 5-Phosphoribose 1-diphosphate biosynthesis.
    UniPathwayiUPA00087; UER00172.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribose-phosphate pyrophosphokinase 1 (EC:2.7.6.1)
    Alternative name(s):
    Phosphoribosyl pyrophosphate synthase I
    Short name:
    PRS-I
    Gene namesi
    Name:PRPS1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome X

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 318317Ribose-phosphate pyrophosphokinase 1PRO_0000244988Add
    BLAST

    Proteomic databases

    PaxDbiQ2HJ58.
    PRIDEiQ2HJ58.

    Interactioni

    Subunit structurei

    Homodimer. The active form is probably a hexamer composed of 3 homodimers By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ2HJ58.
    SMRiQ2HJ58. Positions 3-317.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni212 – 22716Binding of phosphoribosylpyrophosphateSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0462.
    GeneTreeiENSGT00550000074583.
    HOGENOMiHOG000210451.
    HOVERGENiHBG001520.
    InParanoidiQ2HJ58.
    KOiK00948.
    OMAiNISERNC.
    OrthoDBiEOG7G4QG5.
    TreeFamiTF106366.

    Family and domain databases

    Gene3Di3.40.50.2020. 2 hits.
    HAMAPiMF_00583_B. RibP_PPkinase_B.
    InterProiIPR000842. PRib_PP_synth_CS.
    IPR029099. Pribosyltran_N.
    IPR029057. PRTase-like.
    IPR005946. Rib-P_diPkinase.
    [Graphical view]
    PfamiPF14572. Pribosyl_synth. 1 hit.
    PF13793. Pribosyltran_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
    PROSITEiPS00114. PRPP_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2HJ58-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPNIKIFSGS SHQDLSQKIA DRLGLELGKV VTKKFSNQET CVEIGESVRG    50
    EDVYIVQSGC GEINDNLMEL LIMINACKIA SASRVTAVIP CFPYARQDKK 100
    DKSRAPISAK LVANMLSVAG ADHIITMDLH ASQIQGFFDI PVDNLYAEPA 150
    VLKWIRENIS EWRNCTIVSP DAGGAKRVTS IADRLNVDFA LIHKERKKAN 200
    EVDRMVLVGD VKDRVAILVD DMADTCGTIC HAADKLLSAG ATRVYAILTH 250
    GIFSGPAISR INNACFEAVV VTNTIPQEDK MKHCSKIQVI DISMILAEAI 300
    RRTHNGESVS YLFSHVPL 318
    Length:318
    Mass (Da):34,834
    Last modified:January 23, 2007 - v3
    Checksum:i46D017E969908BA0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC113300 mRNA. Translation: AAI13301.1.
    BC142427 mRNA. Translation: AAI42428.1.
    RefSeqiNP_001039654.1. NM_001046189.2.
    UniGeneiBt.63570.

    Genome annotation databases

    EnsembliENSBTAT00000026261; ENSBTAP00000026261; ENSBTAG00000019703.
    GeneIDi781227.
    KEGGibta:781227.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC113300 mRNA. Translation: AAI13301.1 .
    BC142427 mRNA. Translation: AAI42428.1 .
    RefSeqi NP_001039654.1. NM_001046189.2.
    UniGenei Bt.63570.

    3D structure databases

    ProteinModelPortali Q2HJ58.
    SMRi Q2HJ58. Positions 3-317.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q2HJ58.

    Proteomic databases

    PaxDbi Q2HJ58.
    PRIDEi Q2HJ58.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000026261 ; ENSBTAP00000026261 ; ENSBTAG00000019703 .
    GeneIDi 781227.
    KEGGi bta:781227.

    Organism-specific databases

    CTDi 5631.

    Phylogenomic databases

    eggNOGi COG0462.
    GeneTreei ENSGT00550000074583.
    HOGENOMi HOG000210451.
    HOVERGENi HBG001520.
    InParanoidi Q2HJ58.
    KOi K00948.
    OMAi NISERNC.
    OrthoDBi EOG7G4QG5.
    TreeFami TF106366.

    Enzyme and pathway databases

    UniPathwayi UPA00087 ; UER00172 .
    Reactomei REACT_205661. 5-Phosphoribose 1-diphosphate biosynthesis.

    Miscellaneous databases

    NextBioi 20924697.

    Family and domain databases

    Gene3Di 3.40.50.2020. 2 hits.
    HAMAPi MF_00583_B. RibP_PPkinase_B.
    InterProi IPR000842. PRib_PP_synth_CS.
    IPR029099. Pribosyltran_N.
    IPR029057. PRTase-like.
    IPR005946. Rib-P_diPkinase.
    [Graphical view ]
    Pfami PF14572. Pribosyl_synth. 1 hit.
    PF13793. Pribosyltran_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01251. ribP_PPkin. 1 hit.
    PROSITEi PS00114. PRPP_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal medulla and Uterus.

    Entry informationi

    Entry nameiPRPS1_BOVIN
    AccessioniPrimary (citable) accession number: Q2HJ58
    Secondary accession number(s): A5PKB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3