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Q2HJ58

- PRPS1_BOVIN

UniProt

Q2HJ58 - PRPS1_BOVIN

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Protein
Ribose-phosphate pyrophosphokinase 1
Gene
PRPS1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.UniRule annotation

Catalytic activityi

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Enzyme regulationi

Activated by magnesium and inorganic phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi128 – 1281Magnesium Reviewed prediction
Metal bindingi130 – 1301Magnesium Reviewed prediction
Binding sitei130 – 1301ATP By similarity
Metal bindingi139 – 1391Magnesium Reviewed prediction
Metal bindingi143 – 1431Magnesium Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi96 – 1016ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. kinase activity Source: UniProtKB-KW
  3. magnesium ion binding Source: InterPro
  4. protein homodimerization activity Source: UniProtKB
  5. ribose phosphate diphosphokinase activity Source: UniProtKB

GO - Biological processi

  1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. hypoxanthine biosynthetic process Source: Ensembl
  3. nervous system development Source: Ensembl
  4. purine nucleotide biosynthetic process Source: Ensembl
  5. ribonucleoside monophosphate biosynthetic process Source: InterPro
  6. urate biosynthetic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_205661. 5-Phosphoribose 1-diphosphate biosynthesis.
UniPathwayiUPA00087; UER00172.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-phosphate pyrophosphokinase 1 (EC:2.7.6.1)
Alternative name(s):
Phosphoribosyl pyrophosphate synthase I
Short name:
PRS-I
Gene namesi
Name:PRPS1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome X

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 318317Ribose-phosphate pyrophosphokinase 1UniRule annotation
PRO_0000244988Add
BLAST

Proteomic databases

PaxDbiQ2HJ58.
PRIDEiQ2HJ58.

Interactioni

Subunit structurei

Homodimer. The active form is probably a hexamer composed of 3 homodimers By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ2HJ58.
SMRiQ2HJ58. Positions 3-317.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni212 – 22716Binding of phosphoribosylpyrophosphate Reviewed prediction
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0462.
GeneTreeiENSGT00550000074583.
HOGENOMiHOG000210451.
HOVERGENiHBG001520.
InParanoidiQ2HJ58.
KOiK00948.
OMAiNISERNC.
OrthoDBiEOG7G4QG5.
TreeFamiTF106366.

Family and domain databases

Gene3Di3.40.50.2020. 2 hits.
HAMAPiMF_00583_B. RibP_PPkinase_B.
InterProiIPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
PROSITEiPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2HJ58-1 [UniParc]FASTAAdd to Basket

« Hide

MPNIKIFSGS SHQDLSQKIA DRLGLELGKV VTKKFSNQET CVEIGESVRG    50
EDVYIVQSGC GEINDNLMEL LIMINACKIA SASRVTAVIP CFPYARQDKK 100
DKSRAPISAK LVANMLSVAG ADHIITMDLH ASQIQGFFDI PVDNLYAEPA 150
VLKWIRENIS EWRNCTIVSP DAGGAKRVTS IADRLNVDFA LIHKERKKAN 200
EVDRMVLVGD VKDRVAILVD DMADTCGTIC HAADKLLSAG ATRVYAILTH 250
GIFSGPAISR INNACFEAVV VTNTIPQEDK MKHCSKIQVI DISMILAEAI 300
RRTHNGESVS YLFSHVPL 318
Length:318
Mass (Da):34,834
Last modified:January 23, 2007 - v3
Checksum:i46D017E969908BA0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC113300 mRNA. Translation: AAI13301.1.
BC142427 mRNA. Translation: AAI42428.1.
RefSeqiNP_001039654.1. NM_001046189.2.
UniGeneiBt.63570.

Genome annotation databases

EnsembliENSBTAT00000026261; ENSBTAP00000026261; ENSBTAG00000019703.
GeneIDi781227.
KEGGibta:781227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC113300 mRNA. Translation: AAI13301.1 .
BC142427 mRNA. Translation: AAI42428.1 .
RefSeqi NP_001039654.1. NM_001046189.2.
UniGenei Bt.63570.

3D structure databases

ProteinModelPortali Q2HJ58.
SMRi Q2HJ58. Positions 3-317.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q2HJ58.

Proteomic databases

PaxDbi Q2HJ58.
PRIDEi Q2HJ58.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000026261 ; ENSBTAP00000026261 ; ENSBTAG00000019703 .
GeneIDi 781227.
KEGGi bta:781227.

Organism-specific databases

CTDi 5631.

Phylogenomic databases

eggNOGi COG0462.
GeneTreei ENSGT00550000074583.
HOGENOMi HOG000210451.
HOVERGENi HBG001520.
InParanoidi Q2HJ58.
KOi K00948.
OMAi NISERNC.
OrthoDBi EOG7G4QG5.
TreeFami TF106366.

Enzyme and pathway databases

UniPathwayi UPA00087 ; UER00172 .
Reactomei REACT_205661. 5-Phosphoribose 1-diphosphate biosynthesis.

Miscellaneous databases

NextBioi 20924697.

Family and domain databases

Gene3Di 3.40.50.2020. 2 hits.
HAMAPi MF_00583_B. RibP_PPkinase_B.
InterProi IPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view ]
Pfami PF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01251. ribP_PPkin. 1 hit.
PROSITEi PS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal medulla and Uterus.

Entry informationi

Entry nameiPRPS1_BOVIN
AccessioniPrimary (citable) accession number: Q2HJ58
Secondary accession number(s): A5PKB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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