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Q2HJ58 (PRPS1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase 1

EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase I
Short name=PRS-I
Gene names
Name:PRPS1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. HAMAP-Rule MF_00583_B

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00583_B

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00583_B

Enzyme regulation

Activated by magnesium and inorganic phosphate. HAMAP-Rule MF_00583_B

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP-Rule MF_00583_B

Subunit structure

Homodimer. The active form is probably a hexamer composed of 3 homodimers By similarity.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 318317Ribose-phosphate pyrophosphokinase 1 HAMAP-Rule MF_00583_B
PRO_0000244988

Regions

Nucleotide binding96 – 1016ATP By similarity
Region212 – 22716Binding of phosphoribosylpyrophosphate Potential

Sites

Metal binding1281Magnesium Potential
Metal binding1301Magnesium Potential
Metal binding1391Magnesium Potential
Metal binding1431Magnesium Potential
Binding site1301ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2HJ58 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 46D017E969908BA0

FASTA31834,834
        10         20         30         40         50         60 
MPNIKIFSGS SHQDLSQKIA DRLGLELGKV VTKKFSNQET CVEIGESVRG EDVYIVQSGC 

        70         80         90        100        110        120 
GEINDNLMEL LIMINACKIA SASRVTAVIP CFPYARQDKK DKSRAPISAK LVANMLSVAG 

       130        140        150        160        170        180 
ADHIITMDLH ASQIQGFFDI PVDNLYAEPA VLKWIRENIS EWRNCTIVSP DAGGAKRVTS 

       190        200        210        220        230        240 
IADRLNVDFA LIHKERKKAN EVDRMVLVGD VKDRVAILVD DMADTCGTIC HAADKLLSAG 

       250        260        270        280        290        300 
ATRVYAILTH GIFSGPAISR INNACFEAVV VTNTIPQEDK MKHCSKIQVI DISMILAEAI 

       310 
RRTHNGESVS YLFSHVPL 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal medulla and Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC113300 mRNA. Translation: AAI13301.1.
BC142427 mRNA. Translation: AAI42428.1.
RefSeqNP_001039654.1. NM_001046189.2.
UniGeneBt.63570.

3D structure databases

ProteinModelPortalQ2HJ58.
SMRQ2HJ58. Positions 3-317.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ2HJ58.

Proteomic databases

PaxDbQ2HJ58.
PRIDEQ2HJ58.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000026261; ENSBTAP00000026261; ENSBTAG00000019703.
GeneID781227.
KEGGbta:781227.

Organism-specific databases

CTD5631.

Phylogenomic databases

eggNOGCOG0462.
GeneTreeENSGT00550000074583.
HOGENOMHOG000210451.
HOVERGENHBG001520.
InParanoidQ2HJ58.
KOK00948.
OMAASHIVTI.
OrthoDBEOG7G4QG5.
TreeFamTF106366.

Enzyme and pathway databases

UniPathwayUPA00087; UER00172.

Family and domain databases

HAMAPMF_00583_B. RibP_PPkinase_B.
InterProIPR000842. PRib_PP_synth_CS.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamPF14572. Pribosyl_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. ribP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20924697.

Entry information

Entry namePRPS1_BOVIN
AccessionPrimary (citable) accession number: Q2HJ58
Secondary accession number(s): A5PKB5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways