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Protein

Cytokine-inducible SH2-containing protein

Gene

CISH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation (By similarity). May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Growth regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine-inducible SH2-containing protein
Short name:
CIS
Gene namesi
Name:CISH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445271 – 254Cytokine-inducible SH2-containing proteinAdd BLAST254

Proteomic databases

PaxDbiQ2HJ53.
PRIDEiQ2HJ53.

Expressioni

Gene expression databases

BgeeiENSBTAG00000022622.

Interactioni

Subunit structurei

Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and tyrosine-phosphorylated EPO receptor (EPOR).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000030624.

Structurei

3D structure databases

ProteinModelPortaliQ2HJ53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 188SH2PROSITE-ProRule annotationAdd BLAST107
Domaini205 – 253SOCS boxPROSITE-ProRule annotationAdd BLAST49

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
GeneTreeiENSGT00760000119136.
HOGENOMiHOG000236320.
HOVERGENiHBG002457.
InParanoidiQ2HJ53.
KOiK04701.
OMAiQHYVTSC.
OrthoDBiEOG091G0J75.
TreeFamiTF321368.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR028425. CIS.
IPR000980. SH2.
IPR001496. SOCS_box.
[Graphical view]
PANTHERiPTHR24369:SF65. PTHR24369:SF65. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2HJ53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLCVQGLCP LLAVEQIGQR PLWAQSLELP QQVMQPLSAG AFLEEAVEES
60 70 80 90 100
PAQPEREPKV VDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP
110 120 130 140 150
EGTFLVRDST HPSYLFTLSV KTTRGPTNVR IEYADSSFRL DSNCLSRPRI
160 170 180 190 200
LAFPDVVSLV QHYVASCAAD TRSDSPDLAT TPALPTPKED APGDPALPAT
210 220 230 240 250
AVHLKLVQPF VRRSSTRSLQ HLCRLVINRL VVDVDCLPLP RRMADYLRQY

PFQL
Length:254
Mass (Da):28,397
Last modified:March 21, 2006 - v1
Checksum:iFC5870784F43639B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113307 mRNA. Translation: AAI13308.1.
RefSeqiNP_001040051.1. NM_001046586.1.
UniGeneiBt.4321.

Genome annotation databases

EnsembliENSBTAT00000030652; ENSBTAP00000030624; ENSBTAG00000022622.
GeneIDi616753.
KEGGibta:616753.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113307 mRNA. Translation: AAI13308.1.
RefSeqiNP_001040051.1. NM_001046586.1.
UniGeneiBt.4321.

3D structure databases

ProteinModelPortaliQ2HJ53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000030624.

Proteomic databases

PaxDbiQ2HJ53.
PRIDEiQ2HJ53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000030652; ENSBTAP00000030624; ENSBTAG00000022622.
GeneIDi616753.
KEGGibta:616753.

Organism-specific databases

CTDi1154.

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
GeneTreeiENSGT00760000119136.
HOGENOMiHOG000236320.
HOVERGENiHBG002457.
InParanoidiQ2HJ53.
KOiK04701.
OMAiQHYVTSC.
OrthoDBiEOG091G0J75.
TreeFamiTF321368.

Enzyme and pathway databases

UniPathwayiUPA00143.

Gene expression databases

BgeeiENSBTAG00000022622.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR028425. CIS.
IPR000980. SH2.
IPR001496. SOCS_box.
[Graphical view]
PANTHERiPTHR24369:SF65. PTHR24369:SF65. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCISH_BOVIN
AccessioniPrimary (citable) accession number: Q2HJ53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 21, 2006
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.