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Protein

Cytokine-inducible SH2-containing protein

Gene

CISH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation (By similarity). May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-BTA-8951664 Neddylation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine-inducible SH2-containing protein
Short name:
CIS
Gene namesi
Name:CISH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Organism-specific databases

VGNCiVGNC:27374 CISH

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445271 – 254Cytokine-inducible SH2-containing proteinAdd BLAST254

Proteomic databases

PaxDbiQ2HJ53
PRIDEiQ2HJ53

Expressioni

Gene expression databases

BgeeiENSBTAG00000022622

Interactioni

Subunit structurei

Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and tyrosine-phosphorylated EPO receptor (EPOR).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000030624

Structurei

3D structure databases

ProteinModelPortaliQ2HJ53
SMRiQ2HJ53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 188SH2PROSITE-ProRule annotationAdd BLAST107
Domaini205 – 253SOCS boxPROSITE-ProRule annotationAdd BLAST49

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000236320
HOVERGENiHBG002457
InParanoidiQ2HJ53
KOiK04701
OMAiQHYVTSC
OrthoDBiEOG091G0J75
TreeFamiTF321368

Family and domain databases

CDDicd10718 SH2_CIS, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR028425 CIS
IPR035887 CIS_SH2
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44649 PTHR44649, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF07525 SOCS_box, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q2HJ53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLCVQGLCP LLAVEQIGQR PLWAQSLELP QQVMQPLSAG AFLEEAVEES
60 70 80 90 100
PAQPEREPKV VDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP
110 120 130 140 150
EGTFLVRDST HPSYLFTLSV KTTRGPTNVR IEYADSSFRL DSNCLSRPRI
160 170 180 190 200
LAFPDVVSLV QHYVASCAAD TRSDSPDLAT TPALPTPKED APGDPALPAT
210 220 230 240 250
AVHLKLVQPF VRRSSTRSLQ HLCRLVINRL VVDVDCLPLP RRMADYLRQY

PFQL
Length:254
Mass (Da):28,397
Last modified:March 21, 2006 - v1
Checksum:iFC5870784F43639B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113307 mRNA Translation: AAI13308.1
RefSeqiNP_001040051.1, NM_001046586.1
UniGeneiBt.4321

Genome annotation databases

EnsembliENSBTAT00000030652; ENSBTAP00000030624; ENSBTAG00000022622
GeneIDi616753
KEGGibta:616753

Similar proteinsi

Entry informationi

Entry nameiCISH_BOVIN
AccessioniPrimary (citable) accession number: Q2HJ53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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