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Protein

Density-regulated protein

Gene

DENR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Density-regulated protein
Short name:
DRP
Gene namesi
Name:DENR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 198197Density-regulated proteinPRO_0000322640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei73 – 731PhosphoserineBy similarity
Modified residuei86 – 861PhosphothreonineBy similarity
Modified residuei189 – 1891PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ2HJ47.
PeptideAtlasiQ2HJ47.
PRIDEiQ2HJ47.

Interactioni

Subunit structurei

Interacts with MCTS1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000046224.

Structurei

3D structure databases

ProteinModelPortaliQ2HJ47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 18268SUI1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DENR family.Curated
Contains 1 SUI1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3239. Eukaryota.
COG0023. LUCA.
GeneTreeiENSGT00390000014349.
HOGENOMiHOG000237611.
HOVERGENiHBG005471.
InParanoidiQ2HJ47.
OMAiSGGHDCK.
OrthoDBiEOG7T4MMN.
TreeFamiTF105912.

Family and domain databases

Gene3Di3.30.780.10. 1 hit.
InterProiIPR005873. Drp1.
IPR001950. TIF_SUI1.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
SUPFAMiSSF55159. SSF55159. 2 hits.
TIGRFAMsiTIGR01159. DRP1. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2HJ47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADISESGG HDCRGDQRSN TKLDADYPLR VLYCGVCSLP TEYCEYMPDV
60 70 80 90 100
AKCRQWLEKN FPNEFAKLTV ENSPKQEAGI SEGQGTAGEE EEKKKQKRGG
110 120 130 140 150
RGQIKQKKKT VPQKVTIAKI PRAKKKYVTR VCGLATFEID LKEAQRFFAQ
160 170 180 190
KFSCGASVTG EDEIIIQGDF TDDIIDVIQE KWPEVDDDSI EDLGEVKK
Length:198
Mass (Da):22,217
Last modified:March 21, 2006 - v1
Checksum:iE1CCFEB236B09286
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113316 mRNA. Translation: AAI13317.1.
RefSeqiNP_001039993.1. NM_001046528.1.
XP_001252166.1. XM_001252165.6.
XP_015330995.1. XM_015475509.1.
UniGeneiBt.88754.

Genome annotation databases

EnsembliENSBTAT00000049318; ENSBTAP00000046224; ENSBTAG00000034850.
GeneIDi101905534.
614238.
KEGGibta:101905534.
bta:614238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113316 mRNA. Translation: AAI13317.1.
RefSeqiNP_001039993.1. NM_001046528.1.
XP_001252166.1. XM_001252165.6.
XP_015330995.1. XM_015475509.1.
UniGeneiBt.88754.

3D structure databases

ProteinModelPortaliQ2HJ47.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000046224.

Proteomic databases

PaxDbiQ2HJ47.
PeptideAtlasiQ2HJ47.
PRIDEiQ2HJ47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000049318; ENSBTAP00000046224; ENSBTAG00000034850.
GeneIDi101905534.
614238.
KEGGibta:101905534.
bta:614238.

Organism-specific databases

CTDi8562.

Phylogenomic databases

eggNOGiKOG3239. Eukaryota.
COG0023. LUCA.
GeneTreeiENSGT00390000014349.
HOGENOMiHOG000237611.
HOVERGENiHBG005471.
InParanoidiQ2HJ47.
OMAiSGGHDCK.
OrthoDBiEOG7T4MMN.
TreeFamiTF105912.

Family and domain databases

Gene3Di3.30.780.10. 1 hit.
InterProiIPR005873. Drp1.
IPR001950. TIF_SUI1.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
SUPFAMiSSF55159. SSF55159. 2 hits.
TIGRFAMsiTIGR01159. DRP1. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiDENR_BOVIN
AccessioniPrimary (citable) accession number: Q2HJ47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 21, 2006
Last modified: July 6, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.