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Protein

Density-regulated protein

Gene

DENR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Density-regulated protein
Short name:
DRP
Gene namesi
Name:DENR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003226402 – 198Density-regulated proteinAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei73PhosphoserineBy similarity1
Modified residuei86PhosphothreonineBy similarity1
Modified residuei189PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ2HJ47.
PeptideAtlasiQ2HJ47.
PRIDEiQ2HJ47.

Expressioni

Gene expression databases

BgeeiENSBTAG00000034850.

Interactioni

Subunit structurei

Interacts with MCTS1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000046224.

Structurei

3D structure databases

ProteinModelPortaliQ2HJ47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 182SUI1PROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Belongs to the DENR family.Curated
Contains 1 SUI1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3239. Eukaryota.
COG0023. LUCA.
GeneTreeiENSGT00390000014349.
HOGENOMiHOG000237611.
HOVERGENiHBG005471.
InParanoidiQ2HJ47.
OMAiSGGHDCK.
OrthoDBiEOG091G0R9X.
TreeFamiTF105912.

Family and domain databases

Gene3Di3.30.780.10. 1 hit.
InterProiIPR005873. Drp1.
IPR001950. SUI1.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
SUPFAMiSSF55159. SSF55159. 2 hits.
TIGRFAMsiTIGR01159. DRP1. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2HJ47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADISESGG HDCRGDQRSN TKLDADYPLR VLYCGVCSLP TEYCEYMPDV
60 70 80 90 100
AKCRQWLEKN FPNEFAKLTV ENSPKQEAGI SEGQGTAGEE EEKKKQKRGG
110 120 130 140 150
RGQIKQKKKT VPQKVTIAKI PRAKKKYVTR VCGLATFEID LKEAQRFFAQ
160 170 180 190
KFSCGASVTG EDEIIIQGDF TDDIIDVIQE KWPEVDDDSI EDLGEVKK
Length:198
Mass (Da):22,217
Last modified:March 21, 2006 - v1
Checksum:iE1CCFEB236B09286
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113316 mRNA. Translation: AAI13317.1.
RefSeqiNP_001039993.1. NM_001046528.1.
XP_001252166.1. XM_001252165.6.
XP_015330995.1. XM_015475509.1.
UniGeneiBt.88754.

Genome annotation databases

EnsembliENSBTAT00000049318; ENSBTAP00000046224; ENSBTAG00000034850.
GeneIDi101905534.
614238.
KEGGibta:101905534.
bta:614238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113316 mRNA. Translation: AAI13317.1.
RefSeqiNP_001039993.1. NM_001046528.1.
XP_001252166.1. XM_001252165.6.
XP_015330995.1. XM_015475509.1.
UniGeneiBt.88754.

3D structure databases

ProteinModelPortaliQ2HJ47.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000046224.

Proteomic databases

PaxDbiQ2HJ47.
PeptideAtlasiQ2HJ47.
PRIDEiQ2HJ47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000049318; ENSBTAP00000046224; ENSBTAG00000034850.
GeneIDi101905534.
614238.
KEGGibta:101905534.
bta:614238.

Organism-specific databases

CTDi8562.

Phylogenomic databases

eggNOGiKOG3239. Eukaryota.
COG0023. LUCA.
GeneTreeiENSGT00390000014349.
HOGENOMiHOG000237611.
HOVERGENiHBG005471.
InParanoidiQ2HJ47.
OMAiSGGHDCK.
OrthoDBiEOG091G0R9X.
TreeFamiTF105912.

Gene expression databases

BgeeiENSBTAG00000034850.

Family and domain databases

Gene3Di3.30.780.10. 1 hit.
InterProiIPR005873. Drp1.
IPR001950. SUI1.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
SUPFAMiSSF55159. SSF55159. 2 hits.
TIGRFAMsiTIGR01159. DRP1. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDENR_BOVIN
AccessioniPrimary (citable) accession number: Q2HJ47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 21, 2006
Last modified: November 30, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.