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Q2HJ44

- GLD2_BOVIN

UniProt

Q2HJ44 - GLD2_BOVIN

Protein

Poly(A) RNA polymerase GLD2

Gene

PAPD4

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation By similarity.By similarity

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi213 – 2131Magnesium or manganese; catalyticBy similarity
    Metal bindingi215 – 2151Magnesium or manganese; catalyticBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. polynucleotide adenylyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. histone mRNA catabolic process Source: UniProtKB
    2. mRNA processing Source: UniProtKB-KW
    3. RNA polyadenylation Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) RNA polymerase GLD2 (EC:2.7.7.19)
    Alternative name(s):
    PAP-associated domain-containing protein 4
    Gene namesi
    Name:PAPD4
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 10

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484Poly(A) RNA polymerase GLD2PRO_0000341548Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei62 – 621PhosphoserineBy similarity
    Modified residuei69 – 691PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ2HJ44.

    Interactioni

    Subunit structurei

    Interacts with CPEB1, CPEB2, CPSF1 and PABPC1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ2HJ44.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini386 – 44055PAP-associatedAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi76 – 9217Nuclear localization signalSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PAP-associated domain.Curated

    Phylogenomic databases

    eggNOGiCOG5260.
    GeneTreeiENSGT00550000074490.
    HOGENOMiHOG000088606.
    HOVERGENiHBG097533.
    InParanoidiQ2HJ44.
    KOiK14079.
    OMAiCVEFDLN.
    OrthoDBiEOG7DRJ2S.
    TreeFamiTF315661.

    Family and domain databases

    InterProiIPR002058. PAP_assoc.
    [Graphical view]
    PfamiPF03828. PAP_assoc. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q2HJ44-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFPNSILGRP PFTPNHQQHN NFFALSPSLY SHQQLIDAQF SFHNADLSRA    50
    VSLQQLTYGN VSPIQTSTSP LFRGRKRLSD EKNLPLDGKR QRFHSPHQEP 100
    TIVNHIVPLS DERRYSMSPL FHTHYVPDIV RCVPPFREIS ILEPREITLP 150
    EAKDKLSQQI LELFEACQQQ VSDLKKKELC RTELQREIQL LFPQSRLFLV 200
    GSSLNGFGTR SSDGDLCLVV KEEPCFFQVN QKTEARHILT LVHKHFCTRL 250
    SGYIERPQLI RAKVPIVKFR DKVSCVEFDL NVNNIVGIRN TFLLRTYAYL 300
    ENRVRPLVLV IKKWASHHDI NDASRGTLSS YSLVLMVLHY LQTLPEPILP 350
    SIQKIYPESF SPSIQLHLVH QAPCNVPPYL SKNESNLGDL LLGFLKYYAT 400
    EFDWNSQMIS VREAKAIPRP DGIEWRNKYI CVEEPFDGTN TARAVHEKQK 450
    FDMIKDQFLK SWHRLKNRKD LNSILPLRAA ILKR 484
    Length:484
    Mass (Da):56,051
    Last modified:March 21, 2006 - v1
    Checksum:iEA2345615C844818
    GO
    Isoform 2 (identifier: Q2HJ44-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         157-163: SQQILEL → NKRTLTW
         164-484: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:163
    Mass (Da):18,919
    Checksum:i5B86ED9719BCA532
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei157 – 1637SQQILEL → NKRTLTW in isoform 2. 1 PublicationVSP_034322
    Alternative sequencei164 – 484321Missing in isoform 2. 1 PublicationVSP_034323Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT025394 mRNA. Translation: ABF57350.1.
    BC113319 mRNA. Translation: AAI13320.1.
    RefSeqiNP_001039826.1. NM_001046361.1. [Q2HJ44-1]
    XP_005211397.1. XM_005211340.1. [Q2HJ44-1]
    XP_005211398.1. XM_005211341.1. [Q2HJ44-1]
    XP_005211399.1. XM_005211342.1. [Q2HJ44-1]
    UniGeneiBt.92095.

    Genome annotation databases

    EnsembliENSBTAT00000008885; ENSBTAP00000008885; ENSBTAG00000006751. [Q2HJ44-1]
    ENSBTAT00000048886; ENSBTAP00000045850; ENSBTAG00000006751. [Q2HJ44-2]
    GeneIDi533862.
    KEGGibta:533862.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT025394 mRNA. Translation: ABF57350.1 .
    BC113319 mRNA. Translation: AAI13320.1 .
    RefSeqi NP_001039826.1. NM_001046361.1. [Q2HJ44-1 ]
    XP_005211397.1. XM_005211340.1. [Q2HJ44-1 ]
    XP_005211398.1. XM_005211341.1. [Q2HJ44-1 ]
    XP_005211399.1. XM_005211342.1. [Q2HJ44-1 ]
    UniGenei Bt.92095.

    3D structure databases

    ProteinModelPortali Q2HJ44.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q2HJ44.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000008885 ; ENSBTAP00000008885 ; ENSBTAG00000006751 . [Q2HJ44-1 ]
    ENSBTAT00000048886 ; ENSBTAP00000045850 ; ENSBTAG00000006751 . [Q2HJ44-2 ]
    GeneIDi 533862.
    KEGGi bta:533862.

    Organism-specific databases

    CTDi 167153.

    Phylogenomic databases

    eggNOGi COG5260.
    GeneTreei ENSGT00550000074490.
    HOGENOMi HOG000088606.
    HOVERGENi HBG097533.
    InParanoidi Q2HJ44.
    KOi K14079.
    OMAi CVEFDLN.
    OrthoDBi EOG7DRJ2S.
    TreeFami TF315661.

    Miscellaneous databases

    NextBioi 20876175.

    Family and domain databases

    InterProi IPR002058. PAP_assoc.
    [Graphical view ]
    Pfami PF03828. PAP_assoc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: Hereford.
      Tissue: Uterus.

    Entry informationi

    Entry nameiGLD2_BOVIN
    AccessioniPrimary (citable) accession number: Q2HJ44
    Secondary accession number(s): Q1JPF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3