Reviewed,
UniProtKB/Swiss-Prot Q2HJ44 (GLD2_BOVIN)
Last modified
June 16, 2009.
Version 19.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Poly(A) RNA polymerase GLD2 EC=2.7.7.19 Alternative name(s): PAP-associated domain-containing protein 4 | ||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 484 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs By similarity. |
| Catalytic activity | ATP + RNA(n) = diphosphate + RNA(n+1). |
| Subunit structure | Interacts with CPEB1, CPEB2, CPSF1 and PABPC1 By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the DNA polymerase type-B-like family. GLD2 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | mRNA processing |
| Cellular component | Cytoplasm Nucleus |
| Coding sequence diversity | Alternative splicing |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Transferase |
| Gene Ontology (GO) | |
| Biological process | RNA polyadenylation Inferred from sequence or structural similarity. Source: UniProtKB mRNA processingInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW polynucleotide adenylyltransferase activityInferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q2HJ44-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q2HJ44-2) The sequence of this isoform differs from the canonical sequence as follows: 157-163: SQQILEL → NKRTLTW 164-484: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 484 | 484 | Poly(A) RNA polymerase GLD2 | PRO_0000341548 | |||||
Regions | |||||||||
| Motif | 76 – 92 | 17 | Nuclear localization signal Potential | ||||||
Sites | |||||||||
| Active site | 215 | 1 | By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 157 – 163 | 7 | SQQILEL → NKRTLTW in isoform 2. | VSP_034322 | |||||
| Alternative sequence | 164 – 484 | 321 | Missing in isoform 2. | VSP_034323 | |||||
Sequences
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References
| [1] | "Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). |
| [2] | NIH - Mammalian Gene Collection (MGC) project Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: Hereford. Tissue: Uterus. |
Cross-references
Sequence databases | |
|---|---|
| BT025394 mRNA. Translation: ABF57350.1. BC113319 mRNA. Translation: AAI13320.1. | |
| IPI | IPI00702849. IPI00843674. |
| RefSeq | NP_001039826.1. |
| UniGene | Bt.92095 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAG00000006751. Bos taurus. [Contig view] |
| GeneID | 533862. |
| KEGG | bta:533862. |
Phylogenomic databases | |
| HOVERGEN | Q2HJ44. |
| OMA | Q2HJ44. NQKTEAR. |
Family and domain databases | |
| InterPro | IPR002058. PAP_assoc. [Graphical view] |
| Pfam | PF03828. PAP_assoc. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GLD2_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q2HJ44 Secondary accession number(s): Q1JPF9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


