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Protein

Iron-sulfur clusters transporter ATM1, mitochondrial

Gene

ATM1

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei302Glutathione; via amide nitrogenBy similarity1
Binding sitei354ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi378 – 389ATPPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandATP-binding, Iron, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur clusters transporter ATM1, mitochondrial
Gene namesi
Name:ATM1
ORF Names:CHGG_00005
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
Proteomesi
  • UP000001056 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini? – 19Mitochondrial matrixSequence analysis
Transmembranei20 – 41HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini42 – 64Mitochondrial intermembraneBy similarityAdd BLAST23
Transmembranei65 – 88HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini89 – 137Mitochondrial matrixBy similarityAdd BLAST49
Transmembranei138 – 161HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini162Mitochondrial intermembraneBy similarity1
Transmembranei163 – 183HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini184 – 249Mitochondrial matrixBy similarityAdd BLAST66
Transmembranei250 – 268HelicalPROSITE-ProRule annotationAdd BLAST19
Topological domaini269 – 283Mitochondrial intermembraneBy similarityAdd BLAST15
Transmembranei284 – 305HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini306 – 603Mitochondrial matrixBy similarityAdd BLAST298

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000255442? – 603Iron-sulfur clusters transporter ATM1, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi306901.XP_001219226.1.

Structurei

3D structure databases

ProteinModelPortaliQ2HIE9.
SMRiQ2HIE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 310ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST291
Domaini345 – 581ABC transporterPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni189 – 193Glutathione bindingBy similarity5
Regioni252 – 255Glutathione bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0057. Eukaryota.
COG5265. LUCA.
InParanoidiQ2HIE9.
OrthoDBiEOG092C3H79.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR000836. PRibTrfase_dom.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2HIE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEMSRYLWP KDSWGDKLRV LLAVGLLVGG KVLNVQVPFF FREIVDSLNV
60 70 80 90 100
DIAATGGTVA TVAGTMIFAY GASRIGAVVS QELRNAVFSS VAQKAIRRVA
110 120 130 140 150
TRTFGHLLNL DLNFHLSKQT GGLTRAIDRG TKGISFLLTS MVFHIVPTAL
160 170 180 190 200
EISMVCGILT YQFGWEFAAV TALTMSAYTA FTIWTTAWRT KFRRQANAAD
210 220 230 240 250
NKASTVAVDS LINYEAVKYF NNEKYEIGRY DKALHQYEKS SIKVATSLAF
260 270 280 290 300
LNSGQNIIFS SALTIMMWLG AKGIVAGSLS VGDLVLINQL VFQLSVPLNF
310 320 330 340 350
LGSVYRELRQ SLLDMETLFN LQKVNLSIKE KPNAASLVLP KGGEIRFDNV
360 370 380 390 400
SFGYYPDRPI LNNLSVTIPA GKKVAVVGPS GCGKSTLLRL LFRSYDPQSG
410 420 430 440 450
RIFIDDQDIR DVSLDSLRRS IGVVPQDTPL FNDTVELNIR YGNLDASREK
460 470 480 490 500
VLEAARRAHI HDKIESWPHG YQTKVGERGL MISGGEKQRL AVSRLILKDP
510 520 530 540 550
PLLFFDEATS ALDTHTEQAL MSNINEVLKE KRRTSVFVAH RLRTIYDADV
560 570 580 590 600
IIVLKEGRVV EMGSHRELME GNGLYTELWM AQEMSMHDQS LGRSEREAPV

PVK
Length:603
Mass (Da):67,070
Last modified:March 21, 2006 - v1
Checksum:i10D87CC6264CC055
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408029 Genomic DNA. Translation: EAQ91770.1.
RefSeqiXP_001219226.1. XM_001219225.1.

Genome annotation databases

EnsemblFungiiEAQ91770; EAQ91770; CHGG_00005.
GeneIDi4386662.

Similar proteinsi

Entry informationi

Entry nameiATM1_CHAGB
AccessioniPrimary (citable) accession number: Q2HIE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 21, 2006
Last modified: April 12, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families