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Q2HFZ9 (SSU72_CHAGB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Short name=CTD phosphatase SSU72
EC=3.1.3.16
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene names
Name:SSU72
ORF Names:CHGG_00855
OrganismChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) [Complete proteome]
Taxonomic identifier306901 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1) By similarity.

Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Component of the cleavage and polyadenylation factor (CPF) complex By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the SSU72 phosphatase family.

Ontologies

Keywords
   Biological processmRNA processing
   Cellular componentNucleus
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257RNA polymerase II subunit A C-terminal domain phosphatase SSU72
PRO_0000255606

Sequences

Sequence LengthMass (Da)Tools
Q2HFZ9 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: C629C0EEBBDCD527

FASTA25728,393
        10         20         30         40         50         60 
METANGNAGS AATAQNGQQE DASGFKLKFC TVCASNQNRS MEGHLRLAQA NYPVISFGTG 

        70         80         90        100        110        120 
SLVRLPGPTI TQPNVYKFNE TSYDSIYREL EAKDPRLYRA NGLLNMLGRN RVIKWGPERW 

       130        140        150        160        170        180 
QDWQVGMPRV KHEKDQGSIG MEAGVPDIVI TCEERCWDAV VDDLLNRGSP LNRPVHVINI 

       190        200        210        220        230        240 
DIKDNHQDAS IGGGAMVDLA DSLNRAAMEE RDKVGAAVFD AGGAASRASF DERVPEVLGE 

       250 
WQERWPGLPS TWTLSWF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH408029 Genomic DNA. Translation: EAQ92620.1.
RefSeqXP_001220076.1. XM_001220075.1.

3D structure databases

ProteinModelPortalQ2HFZ9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4388085.

Phylogenomic databases

OrthoDBEOG7GTTG0.

Family and domain databases

InterProIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERPTHR20383. PTHR20383. 1 hit.
PfamPF04722. Ssu72. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSU72_CHAGB
AccessionPrimary (citable) accession number: Q2HFZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 21, 2006
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families