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Q2HFZ9

- SSU72_CHAGB

UniProt

Q2HFZ9 - SSU72_CHAGB

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Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene
SSU72, CHGG_00855
Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1) By similarity.
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
Short name:
CTD phosphatase SSU72
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene namesi
Name:SSU72
ORF Names:CHGG_00855
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
ProteomesiUP000001056: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257RNA polymerase II subunit A C-terminal domain phosphatase SSU72PRO_0000255606Add
BLAST

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ2HFZ9.

Family & Domainsi

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.

Phylogenomic databases

OrthoDBiEOG7GTTG0.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2HFZ9-1 [UniParc]FASTAAdd to Basket

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METANGNAGS AATAQNGQQE DASGFKLKFC TVCASNQNRS MEGHLRLAQA    50
NYPVISFGTG SLVRLPGPTI TQPNVYKFNE TSYDSIYREL EAKDPRLYRA 100
NGLLNMLGRN RVIKWGPERW QDWQVGMPRV KHEKDQGSIG MEAGVPDIVI 150
TCEERCWDAV VDDLLNRGSP LNRPVHVINI DIKDNHQDAS IGGGAMVDLA 200
DSLNRAAMEE RDKVGAAVFD AGGAASRASF DERVPEVLGE WQERWPGLPS 250
TWTLSWF 257
Length:257
Mass (Da):28,393
Last modified:March 21, 2006 - v1
Checksum:iC629C0EEBBDCD527
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408029 Genomic DNA. Translation: EAQ92620.1.
RefSeqiXP_001220076.1. XM_001220075.1.

Genome annotation databases

GeneIDi4388085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408029 Genomic DNA. Translation: EAQ92620.1 .
RefSeqi XP_001220076.1. XM_001220075.1.

3D structure databases

ProteinModelPortali Q2HFZ9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4388085.

Phylogenomic databases

OrthoDBi EOG7GTTG0.

Family and domain databases

InterProi IPR006811. RNA_pol_II_suA.
[Graphical view ]
PANTHERi PTHR20383. PTHR20383. 1 hit.
Pfami PF04722. Ssu72. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Entry informationi

Entry nameiSSU72_CHAGB
AccessioniPrimary (citable) accession number: Q2HFZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 21, 2006
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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