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Q2HFL8

- PMIP_CHAGB

UniProt

Q2HFL8 - PMIP_CHAGB

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi557 – 5571Zinc; catalyticPROSITE-ProRule annotation
    Active sitei558 – 5581PROSITE-ProRule annotation
    Metal bindingi561 – 5611Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi564 – 5641Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    ORF Names:CHGG_00986
    OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
    Taxonomic identifieri306901 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
    ProteomesiUP000001056: Unassembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3737MitochondrionSequence AnalysisAdd
    BLAST
    Chaini38 – 778741Mitochondrial intermediate peptidasePRO_0000338578Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ2HFL8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2HFL8-1 [UniParc]FASTAAdd to Basket

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    MIRTVTRPRQ WQRWVYSSCL LQRAVPPAAA RQQPRFTTSH KANHFGYHQP    50
    IAPVTHAPIT REDDFVLRSV FDYPQFWQDF TSVPGGIPVG LFRNSFLKEP 100
    RGMLTFAYVS LKKARAVVAK VLAASSVTEY RLIVRDLDRL SDILCRVLDM 150
    ADFVRVTHPD PEIQQNASKA WESVYEYMNE LNTMTGLHDQ LATAMANPDV 200
    TVVWSEEEKT VAEVLKLDFT KSAVSLPQKY RDRFVQLSSE ISAVGSAFVQ 250
    EMAPEQETVV LPSSDLRGMD PVRARDLTRR GKVYLPTLSG EAVMALRTVH 300
    DADARKHIFY ASRTASRRSV QMLEYLMRLR SELASLSGFE SYGHLALRDR 350
    MMAKSPEAVD QFLRALVESN RPKAMQEMAE LLAEKQKAYP QTNSLDPWDK 400
    DYYSDIIRRP LRVAGRQGDL LSSYFSLGVP LVGETWHPDV RRLDVVSDTD 450
    GHVAVLYCDL FTRPNKSPNP AHFTLRCSRE IFASEMEEVW EQTQQSNQKS 500
    MFGSPELAAT DGMTFSRHGD SIKQLPTIAL VCDFPQPSKH GDQPALLSFL 550
    QLETLFHEMG HAIHSVLART SFQTVAGTRC ATDLAELPST LMEFFAADAA 600
    VLGQFARHHE TNEPLPYRMV AQKARQTRRF EALDTENQIV TAMFDQALHS 650
    PRAGEPGFDP TAIFHALQRT HSCAPPDPPG TSWPGFFGHL SGYGSVYYSY 700
    LFDRVLAQRV WDVVFKAGER RAALSRENGE KLKQSLLKWG GARDPWKCLA 750
    EALDDDRLAE GGEEAMALVG SWGSTKPR 778
    Length:778
    Mass (Da):87,685
    Last modified:March 21, 2006 - v1
    Checksum:i77933C763AF2F3D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408029 Genomic DNA. Translation: EAQ92751.1.
    RefSeqiXP_001220207.1. XM_001220206.1.

    Genome annotation databases

    GeneIDi4386396.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408029 Genomic DNA. Translation: EAQ92751.1 .
    RefSeqi XP_001220207.1. XM_001220206.1.

    3D structure databases

    ProteinModelPortali Q2HFL8.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4386396.

    Phylogenomic databases

    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

    Entry informationi

    Entry nameiPMIP_CHAGB
    AccessioniPrimary (citable) accession number: Q2HFL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3