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Q2HFL8

- PMIP_CHAGB

UniProt

Q2HFL8 - PMIP_CHAGB

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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi557 – 5571Zinc; catalyticPROSITE-ProRule annotation
Active sitei558 – 5581PROSITE-ProRule annotation
Metal bindingi561 – 5611Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi564 – 5641Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:CHGG_00986
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
ProteomesiUP000001056: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3737MitochondrionSequence AnalysisAdd
BLAST
Chaini38 – 778741Mitochondrial intermediate peptidasePRO_0000338578Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ2HFL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiQ2HFL8.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2HFL8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIRTVTRPRQ WQRWVYSSCL LQRAVPPAAA RQQPRFTTSH KANHFGYHQP
60 70 80 90 100
IAPVTHAPIT REDDFVLRSV FDYPQFWQDF TSVPGGIPVG LFRNSFLKEP
110 120 130 140 150
RGMLTFAYVS LKKARAVVAK VLAASSVTEY RLIVRDLDRL SDILCRVLDM
160 170 180 190 200
ADFVRVTHPD PEIQQNASKA WESVYEYMNE LNTMTGLHDQ LATAMANPDV
210 220 230 240 250
TVVWSEEEKT VAEVLKLDFT KSAVSLPQKY RDRFVQLSSE ISAVGSAFVQ
260 270 280 290 300
EMAPEQETVV LPSSDLRGMD PVRARDLTRR GKVYLPTLSG EAVMALRTVH
310 320 330 340 350
DADARKHIFY ASRTASRRSV QMLEYLMRLR SELASLSGFE SYGHLALRDR
360 370 380 390 400
MMAKSPEAVD QFLRALVESN RPKAMQEMAE LLAEKQKAYP QTNSLDPWDK
410 420 430 440 450
DYYSDIIRRP LRVAGRQGDL LSSYFSLGVP LVGETWHPDV RRLDVVSDTD
460 470 480 490 500
GHVAVLYCDL FTRPNKSPNP AHFTLRCSRE IFASEMEEVW EQTQQSNQKS
510 520 530 540 550
MFGSPELAAT DGMTFSRHGD SIKQLPTIAL VCDFPQPSKH GDQPALLSFL
560 570 580 590 600
QLETLFHEMG HAIHSVLART SFQTVAGTRC ATDLAELPST LMEFFAADAA
610 620 630 640 650
VLGQFARHHE TNEPLPYRMV AQKARQTRRF EALDTENQIV TAMFDQALHS
660 670 680 690 700
PRAGEPGFDP TAIFHALQRT HSCAPPDPPG TSWPGFFGHL SGYGSVYYSY
710 720 730 740 750
LFDRVLAQRV WDVVFKAGER RAALSRENGE KLKQSLLKWG GARDPWKCLA
760 770
EALDDDRLAE GGEEAMALVG SWGSTKPR
Length:778
Mass (Da):87,685
Last modified:March 21, 2006 - v1
Checksum:i77933C763AF2F3D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408029 Genomic DNA. Translation: EAQ92751.1.
RefSeqiXP_001220207.1. XM_001220206.1.

Genome annotation databases

GeneIDi4386396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408029 Genomic DNA. Translation: EAQ92751.1 .
RefSeqi XP_001220207.1. XM_001220206.1.

3D structure databases

ProteinModelPortali Q2HFL8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4386396.

Phylogenomic databases

InParanoidi Q2HFL8.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Entry informationi

Entry nameiPMIP_CHAGB
AccessioniPrimary (citable) accession number: Q2HFL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 21, 2006
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3