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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi557Zinc; catalyticPROSITE-ProRule annotation1
Active sitei558PROSITE-ProRule annotation1
Metal bindingi561Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi564Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:CHGG_00986
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
Proteomesi
  • UP000001056 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 37MitochondrionSequence analysisAdd BLAST37
ChainiPRO_000033857838 – 778Mitochondrial intermediate peptidaseAdd BLAST741

Interactioni

Protein-protein interaction databases

STRINGi306901.XP_001220207.1

Structurei

3D structure databases

ProteinModelPortaliQ2HFL8
SMRiQ2HFL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2090 Eukaryota
COG0339 LUCA
InParanoidiQ2HFL8
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 1 hit
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 2 hits
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2HFL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRTVTRPRQ WQRWVYSSCL LQRAVPPAAA RQQPRFTTSH KANHFGYHQP
60 70 80 90 100
IAPVTHAPIT REDDFVLRSV FDYPQFWQDF TSVPGGIPVG LFRNSFLKEP
110 120 130 140 150
RGMLTFAYVS LKKARAVVAK VLAASSVTEY RLIVRDLDRL SDILCRVLDM
160 170 180 190 200
ADFVRVTHPD PEIQQNASKA WESVYEYMNE LNTMTGLHDQ LATAMANPDV
210 220 230 240 250
TVVWSEEEKT VAEVLKLDFT KSAVSLPQKY RDRFVQLSSE ISAVGSAFVQ
260 270 280 290 300
EMAPEQETVV LPSSDLRGMD PVRARDLTRR GKVYLPTLSG EAVMALRTVH
310 320 330 340 350
DADARKHIFY ASRTASRRSV QMLEYLMRLR SELASLSGFE SYGHLALRDR
360 370 380 390 400
MMAKSPEAVD QFLRALVESN RPKAMQEMAE LLAEKQKAYP QTNSLDPWDK
410 420 430 440 450
DYYSDIIRRP LRVAGRQGDL LSSYFSLGVP LVGETWHPDV RRLDVVSDTD
460 470 480 490 500
GHVAVLYCDL FTRPNKSPNP AHFTLRCSRE IFASEMEEVW EQTQQSNQKS
510 520 530 540 550
MFGSPELAAT DGMTFSRHGD SIKQLPTIAL VCDFPQPSKH GDQPALLSFL
560 570 580 590 600
QLETLFHEMG HAIHSVLART SFQTVAGTRC ATDLAELPST LMEFFAADAA
610 620 630 640 650
VLGQFARHHE TNEPLPYRMV AQKARQTRRF EALDTENQIV TAMFDQALHS
660 670 680 690 700
PRAGEPGFDP TAIFHALQRT HSCAPPDPPG TSWPGFFGHL SGYGSVYYSY
710 720 730 740 750
LFDRVLAQRV WDVVFKAGER RAALSRENGE KLKQSLLKWG GARDPWKCLA
760 770
EALDDDRLAE GGEEAMALVG SWGSTKPR
Length:778
Mass (Da):87,685
Last modified:March 21, 2006 - v1
Checksum:i77933C763AF2F3D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408029 Genomic DNA Translation: EAQ92751.1
RefSeqiXP_001220207.1, XM_001220206.1

Genome annotation databases

EnsemblFungiiEAQ92751; EAQ92751; CHGG_00986
GeneIDi4386396

Entry informationi

Entry nameiPMIP_CHAGB
AccessioniPrimary (citable) accession number: Q2HFL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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