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Protein

Mitochondrial thiamine pyrophosphate carrier 1

Gene

TPC1

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.By similarity

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial thiamine pyrophosphate carrier 1
Gene namesi
Name:TPC1
ORF Names:CHGG_00988
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
Proteomesi
  • UP000001056 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 35Helical; Name=1Sequence analysisAdd BLAST19
Transmembranei92 – 108Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei127 – 143Helical; Name=3Sequence analysisAdd BLAST17
Transmembranei184 – 200Helical; Name=4Sequence analysisAdd BLAST17
Transmembranei223 – 239Helical; Name=5Sequence analysisAdd BLAST17
Transmembranei287 – 304Helical; Name=6Sequence analysisAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003204621 – 325Mitochondrial thiamine pyrophosphate carrier 1Add BLAST325

Structurei

3D structure databases

ProteinModelPortaliQ2HFL6.
SMRiQ2HFL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 111Solcar 1Add BLAST100
Repeati122 – 209Solcar 2Add BLAST88
Repeati216 – 312Solcar 3Add BLAST97

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
InParanoidiQ2HFL6.
OrthoDBiEOG092C3KDM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 2 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q2HFL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKGDRLKD EGSRLQVTAA GATAGLVARF VIAPLDVVKI RLQLQTHSLS
60 70 80 90 100
DPLSHRDLHG GPIYKGTLPT LRHILRSEGI TGLWKGNVPA ELLYVCYSAI
110 120 130 140 150
QFTTYRTTTL LLHQTLGEGT LPPSAESFVA GAIGGGTATA ATYPLDPAAH
160 170 180 190 200
ALRRPGQRSR VCESVARRGP DWVVRRAPVG FFGVWDRAWA QIIPYMSFFF
210 220 230 240 250
ATYETLRPHL SELELPFSSS SAVARTMASV MAKSRTFPLD LVRKRIQVQS
260 270 280 290 300
PTRGRYVHKN IPEYYGGTVG ALRTILQREG LRGLYRGLTV SLLKAAPASA
310 320
VTMWTYERAL KFYSGVGEKG EEQRL
Length:325
Mass (Da):35,755
Last modified:February 26, 2008 - v2
Checksum:i5B63E70CA1E8295A
GO

Sequence cautioni

The sequence EAQ92753 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408029 Genomic DNA. Translation: EAQ92753.1. Sequence problems.
RefSeqiXP_001220209.1. XM_001220208.1.

Genome annotation databases

EnsemblFungiiEAQ92753; EAQ92753; CHGG_00988.
GeneIDi4386398.

Similar proteinsi

Entry informationi

Entry nameiTPC1_CHAGB
AccessioniPrimary (citable) accession number: Q2HFL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 5, 2017
This is version 55 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families