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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei773 – 7731Charge relay systemBy similarity
Active sitei850 – 8501Charge relay systemBy similarity
Active sitei883 – 8831Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:CHGG_01114
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
ProteomesiUP000001056 Componenti: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 110110CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei111 – 13121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini132 – 925794VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 925925Probable dipeptidyl-aminopeptidase BPRO_0000412141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi369 – 3691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi832 – 8321N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ2HF90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ2HF90.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2HF90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPYRDVPPV SSRTHSSNRD RSQSRSRMSH ESGSSVSTTS IVFDRISERV
60 70 80 90 100
AAGDLSEKQP RGDDNEDALK DEPDNDDLET GPFLGNASGN GNSPRHAQKK
110 120 130 140 150
GPGMDRGMRR ALLIAAGLLV SAWVAGLFVY IATKSYKPAS ATAHDPQATI
160 170 180 190 200
VRGSGKAVTL DQVMGSFWRP EVRSIQWIAG PEGEDGLLLE RDAAGKDYLV
210 220 230 240 250
VEDIRSQDAA AVDSSADAQA ADARTLMEKG SFEYGKRVYN AVKVAPSRDL
260 270 280 290 300
QRVLVATDVK SNWRHSSYAA YWIFDVKTQT ADPLVPGEPD ARIQLAQWNP
310 320 330 340 350
TGDAVAFTRD NNLYLRKVGS DNIIQVTKDG GSEVFNGVPD WVYEEEVFSG
360 370 380 390 400
SSATWWSEDG DYIAFLRTNE TGVPEFPIDY FLKRPSGTEP KPGEEAYPET
410 420 430 440 450
RKIKYPKAGA HNPVVELKFY DVVRGDVFSV DISGGFADDD RLITEVVWAG
460 470 480 490 500
KQILVKETNR VSDVMRVVLV DVAARSGKTV RTTDVKAIDG GWFEITHQTK
510 520 530 540 550
HIPADPSKGR EHDGYIDLII HGDGNHLAYF TPLDNPDPVM LTSGDWEVVD
560 570 580 590 600
SPYAVDLDKN VVYFMATKES SIQRHVYQVK LTGEDLTAVS DTSSEGYYAA
610 620 630 640 650
SFSIGGGYAL LTYQGPGIPW QKVISTPSNP RKYEHTVEEN KDLADNAKKH
660 670 680 690 700
ELPIKIYGTI NVDGVELNYV ERRPAHFDAS KKYPVLFQQY SGPGSQTVNK
710 720 730 740 750
KFTVDFQSYV AAGLGYICVT VDGRGTGYIG RKNRVIVRGN LGQWEAHDQI
760 770 780 790 800
AAAKIWAKKK YIDETRLAIW GWSFGGFNAL KTLEQDAGET FRYGMAVAPV
810 820 830 840 850
TDWRFYDSIY TERYMLTPQA NGHGYDTSAI YNTTALGQNV RFLLMHGLAD
860 870 880 890 900
DNVHFQSSLT LLDKLNLAGV ENYDVHVFPD SDHSIYFHNA NRIVYDKLTN
910 920
WLINAFNGEW IKVASPKPNG KRRAA
Length:925
Mass (Da):102,583
Last modified:March 21, 2006 - v1
Checksum:iA6C59C5AB4BE82DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408029 Genomic DNA. Translation: EAQ92879.1.
RefSeqiXP_001220335.1. XM_001220334.1.

Genome annotation databases

GeneIDi4388188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408029 Genomic DNA. Translation: EAQ92879.1.
RefSeqiXP_001220335.1. XM_001220334.1.

3D structure databases

ProteinModelPortaliQ2HF90.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS09.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4388188.

Phylogenomic databases

InParanoidiQ2HF90.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Entry informationi

Entry nameiDAPB_CHAGB
AccessioniPrimary (citable) accession number: Q2HF90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 21, 2006
Last modified: January 7, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.