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Q2HF90

- DAPB_CHAGB

UniProt

Q2HF90 - DAPB_CHAGB

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Protein

Probable dipeptidyl-aminopeptidase B

Gene
DAPB, CHGG_01114
Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei773 – 7731Charge relay system By similarity
Active sitei850 – 8501Charge relay system By similarity
Active sitei883 – 8831Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:CHGG_01114
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
ProteomesiUP000001056: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 110110Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei111 – 13121Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini132 – 925794Vacuolar Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 925925Probable dipeptidyl-aminopeptidase BPRO_0000412141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi369 – 3691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi832 – 8321N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ2HF90.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2HF90-1 [UniParc]FASTAAdd to Basket

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MTPYRDVPPV SSRTHSSNRD RSQSRSRMSH ESGSSVSTTS IVFDRISERV    50
AAGDLSEKQP RGDDNEDALK DEPDNDDLET GPFLGNASGN GNSPRHAQKK 100
GPGMDRGMRR ALLIAAGLLV SAWVAGLFVY IATKSYKPAS ATAHDPQATI 150
VRGSGKAVTL DQVMGSFWRP EVRSIQWIAG PEGEDGLLLE RDAAGKDYLV 200
VEDIRSQDAA AVDSSADAQA ADARTLMEKG SFEYGKRVYN AVKVAPSRDL 250
QRVLVATDVK SNWRHSSYAA YWIFDVKTQT ADPLVPGEPD ARIQLAQWNP 300
TGDAVAFTRD NNLYLRKVGS DNIIQVTKDG GSEVFNGVPD WVYEEEVFSG 350
SSATWWSEDG DYIAFLRTNE TGVPEFPIDY FLKRPSGTEP KPGEEAYPET 400
RKIKYPKAGA HNPVVELKFY DVVRGDVFSV DISGGFADDD RLITEVVWAG 450
KQILVKETNR VSDVMRVVLV DVAARSGKTV RTTDVKAIDG GWFEITHQTK 500
HIPADPSKGR EHDGYIDLII HGDGNHLAYF TPLDNPDPVM LTSGDWEVVD 550
SPYAVDLDKN VVYFMATKES SIQRHVYQVK LTGEDLTAVS DTSSEGYYAA 600
SFSIGGGYAL LTYQGPGIPW QKVISTPSNP RKYEHTVEEN KDLADNAKKH 650
ELPIKIYGTI NVDGVELNYV ERRPAHFDAS KKYPVLFQQY SGPGSQTVNK 700
KFTVDFQSYV AAGLGYICVT VDGRGTGYIG RKNRVIVRGN LGQWEAHDQI 750
AAAKIWAKKK YIDETRLAIW GWSFGGFNAL KTLEQDAGET FRYGMAVAPV 800
TDWRFYDSIY TERYMLTPQA NGHGYDTSAI YNTTALGQNV RFLLMHGLAD 850
DNVHFQSSLT LLDKLNLAGV ENYDVHVFPD SDHSIYFHNA NRIVYDKLTN 900
WLINAFNGEW IKVASPKPNG KRRAA 925
Length:925
Mass (Da):102,583
Last modified:March 21, 2006 - v1
Checksum:iA6C59C5AB4BE82DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408029 Genomic DNA. Translation: EAQ92879.1.
RefSeqiXP_001220335.1. XM_001220334.1.

Genome annotation databases

GeneIDi4388188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408029 Genomic DNA. Translation: EAQ92879.1 .
RefSeqi XP_001220335.1. XM_001220334.1.

3D structure databases

ProteinModelPortali Q2HF90.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4388188.

Phylogenomic databases

OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Entry informationi

Entry nameiDAPB_CHAGB
AccessioniPrimary (citable) accession number: Q2HF90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 21, 2006
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi