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Q2HF90 (DAPB_CHAGB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:CHGG_01114
OrganismChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) [Complete proteome]
Taxonomic identifier306901 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium

Protein attributes

Sequence length925 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 925925Probable dipeptidyl-aminopeptidase B
PRO_0000412141

Regions

Topological domain1 – 110110Cytoplasmic Potential
Transmembrane111 – 13121Helical; Signal-anchor for type II membrane protein; Potential
Topological domain132 – 925794Vacuolar Potential

Sites

Active site7731Charge relay system By similarity
Active site8501Charge relay system By similarity
Active site8831Charge relay system By similarity

Amino acid modifications

Glycosylation3691N-linked (GlcNAc...) Potential
Glycosylation8321N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q2HF90 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: A6C59C5AB4BE82DF

FASTA925102,583
        10         20         30         40         50         60 
MTPYRDVPPV SSRTHSSNRD RSQSRSRMSH ESGSSVSTTS IVFDRISERV AAGDLSEKQP 

        70         80         90        100        110        120 
RGDDNEDALK DEPDNDDLET GPFLGNASGN GNSPRHAQKK GPGMDRGMRR ALLIAAGLLV 

       130        140        150        160        170        180 
SAWVAGLFVY IATKSYKPAS ATAHDPQATI VRGSGKAVTL DQVMGSFWRP EVRSIQWIAG 

       190        200        210        220        230        240 
PEGEDGLLLE RDAAGKDYLV VEDIRSQDAA AVDSSADAQA ADARTLMEKG SFEYGKRVYN 

       250        260        270        280        290        300 
AVKVAPSRDL QRVLVATDVK SNWRHSSYAA YWIFDVKTQT ADPLVPGEPD ARIQLAQWNP 

       310        320        330        340        350        360 
TGDAVAFTRD NNLYLRKVGS DNIIQVTKDG GSEVFNGVPD WVYEEEVFSG SSATWWSEDG 

       370        380        390        400        410        420 
DYIAFLRTNE TGVPEFPIDY FLKRPSGTEP KPGEEAYPET RKIKYPKAGA HNPVVELKFY 

       430        440        450        460        470        480 
DVVRGDVFSV DISGGFADDD RLITEVVWAG KQILVKETNR VSDVMRVVLV DVAARSGKTV 

       490        500        510        520        530        540 
RTTDVKAIDG GWFEITHQTK HIPADPSKGR EHDGYIDLII HGDGNHLAYF TPLDNPDPVM 

       550        560        570        580        590        600 
LTSGDWEVVD SPYAVDLDKN VVYFMATKES SIQRHVYQVK LTGEDLTAVS DTSSEGYYAA 

       610        620        630        640        650        660 
SFSIGGGYAL LTYQGPGIPW QKVISTPSNP RKYEHTVEEN KDLADNAKKH ELPIKIYGTI 

       670        680        690        700        710        720 
NVDGVELNYV ERRPAHFDAS KKYPVLFQQY SGPGSQTVNK KFTVDFQSYV AAGLGYICVT 

       730        740        750        760        770        780 
VDGRGTGYIG RKNRVIVRGN LGQWEAHDQI AAAKIWAKKK YIDETRLAIW GWSFGGFNAL 

       790        800        810        820        830        840 
KTLEQDAGET FRYGMAVAPV TDWRFYDSIY TERYMLTPQA NGHGYDTSAI YNTTALGQNV 

       850        860        870        880        890        900 
RFLLMHGLAD DNVHFQSSLT LLDKLNLAGV ENYDVHVFPD SDHSIYFHNA NRIVYDKLTN 

       910        920 
WLINAFNGEW IKVASPKPNG KRRAA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH408029 Genomic DNA. Translation: EAQ92879.1.
RefSeqXP_001220335.1. XM_001220334.1.

3D structure databases

ProteinModelPortalQ2HF90.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4388188.

Phylogenomic databases

OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDAPB_CHAGB
AccessionPrimary (citable) accession number: Q2HF90
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 21, 2006
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries