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Q2HF90

- DAPB_CHAGB

UniProt

Q2HF90 - DAPB_CHAGB

Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei773 – 7731Charge relay systemBy similarity
    Active sitei850 – 8501Charge relay systemBy similarity
    Active sitei883 – 8831Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:CHGG_01114
    OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
    Taxonomic identifieri306901 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
    ProteomesiUP000001056: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 925925Probable dipeptidyl-aminopeptidase BPRO_0000412141Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi369 – 3691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi832 – 8321N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ2HF90.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 110110CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini132 – 925794VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei111 – 13121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2HF90-1 [UniParc]FASTAAdd to Basket

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    MTPYRDVPPV SSRTHSSNRD RSQSRSRMSH ESGSSVSTTS IVFDRISERV    50
    AAGDLSEKQP RGDDNEDALK DEPDNDDLET GPFLGNASGN GNSPRHAQKK 100
    GPGMDRGMRR ALLIAAGLLV SAWVAGLFVY IATKSYKPAS ATAHDPQATI 150
    VRGSGKAVTL DQVMGSFWRP EVRSIQWIAG PEGEDGLLLE RDAAGKDYLV 200
    VEDIRSQDAA AVDSSADAQA ADARTLMEKG SFEYGKRVYN AVKVAPSRDL 250
    QRVLVATDVK SNWRHSSYAA YWIFDVKTQT ADPLVPGEPD ARIQLAQWNP 300
    TGDAVAFTRD NNLYLRKVGS DNIIQVTKDG GSEVFNGVPD WVYEEEVFSG 350
    SSATWWSEDG DYIAFLRTNE TGVPEFPIDY FLKRPSGTEP KPGEEAYPET 400
    RKIKYPKAGA HNPVVELKFY DVVRGDVFSV DISGGFADDD RLITEVVWAG 450
    KQILVKETNR VSDVMRVVLV DVAARSGKTV RTTDVKAIDG GWFEITHQTK 500
    HIPADPSKGR EHDGYIDLII HGDGNHLAYF TPLDNPDPVM LTSGDWEVVD 550
    SPYAVDLDKN VVYFMATKES SIQRHVYQVK LTGEDLTAVS DTSSEGYYAA 600
    SFSIGGGYAL LTYQGPGIPW QKVISTPSNP RKYEHTVEEN KDLADNAKKH 650
    ELPIKIYGTI NVDGVELNYV ERRPAHFDAS KKYPVLFQQY SGPGSQTVNK 700
    KFTVDFQSYV AAGLGYICVT VDGRGTGYIG RKNRVIVRGN LGQWEAHDQI 750
    AAAKIWAKKK YIDETRLAIW GWSFGGFNAL KTLEQDAGET FRYGMAVAPV 800
    TDWRFYDSIY TERYMLTPQA NGHGYDTSAI YNTTALGQNV RFLLMHGLAD 850
    DNVHFQSSLT LLDKLNLAGV ENYDVHVFPD SDHSIYFHNA NRIVYDKLTN 900
    WLINAFNGEW IKVASPKPNG KRRAA 925
    Length:925
    Mass (Da):102,583
    Last modified:March 21, 2006 - v1
    Checksum:iA6C59C5AB4BE82DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408029 Genomic DNA. Translation: EAQ92879.1.
    RefSeqiXP_001220335.1. XM_001220334.1.

    Genome annotation databases

    GeneIDi4388188.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408029 Genomic DNA. Translation: EAQ92879.1 .
    RefSeqi XP_001220335.1. XM_001220334.1.

    3D structure databases

    ProteinModelPortali Q2HF90.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4388188.

    Phylogenomic databases

    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

    Entry informationi

    Entry nameiDAPB_CHAGB
    AccessioniPrimary (citable) accession number: Q2HF90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3