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Q2HD63 (3HAO_CHAGB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase

EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Biosynthesis of nicotinic acid protein 1
Gene names
Name:BNA1
ORF Names:CHGG_01841
OrganismChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) [Complete proteome]
Taxonomic identifier306901 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium

Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP-Rule MF_03019

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP-Rule MF_03019

Cofactor

Fe2+ ion By similarity. HAMAP-Rule MF_03019

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. HAMAP-Rule MF_03019

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_03019.

Sequence similarities

Belongs to the 3-HAO family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-hydroxyanthranilate 3,4-dioxygenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1861863-hydroxyanthranilate 3,4-dioxygenase HAMAP-Rule MF_03019
PRO_0000361985

Sites

Metal binding481Iron; catalytic By similarity
Metal binding541Iron; catalytic By similarity
Metal binding961Iron; catalytic By similarity
Metal binding1251Divalent metal cation By similarity
Metal binding1301Divalent metal cation By similarity
Metal binding1641Divalent metal cation By similarity
Metal binding1671Divalent metal cation By similarity
Binding site441Dioxygen By similarity
Binding site541Substrate By similarity
Binding site1001Substrate By similarity
Binding site1101Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2HD63 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 6A9F7228501838E1

FASTA18621,002
        10         20         30         40         50         60 
MIGPPVNLPK WLEENSHLLK PPINNYCVYN GDFTVMIVGG PNARTDYHIN TTPEWFYQHR 

        70         80         90        100        110        120 
GAMTLKIVDP TEGNNTFRDI VIREGDMFLL PANTPHNPVR FADTVGIVLE QKRPAGSLDR 

       130        140        150        160        170        180 
MRWYCQREGC GAVVKEAAFH CTDLGTQIKE AVEAFKADEE GRRCKQCGEV AEWCPKPGSI 


RDPNLE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH408029 Genomic DNA. Translation: EAQ93606.1.
RefSeqXP_001221062.1. XM_001221061.1.

3D structure databases

ProteinModelPortalQ2HD63.
SMRQ2HD63. Positions 5-167.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4386811.

Phylogenomic databases

OrthoDBEOG7QK0Q0.

Enzyme and pathway databases

UniPathwayUPA00253; UER00330.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
HAMAPMF_00825. 3_HAO.
InterProIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR15497. PTHR15497. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_CHAGB
AccessionPrimary (citable) accession number: Q2HD63
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 21, 2006
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways