Q2HA12 (AMPP2_CHAGB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase CHGG_02942
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

CHGG_02942

Organism

Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) [Complete proteome]

Taxonomic identifier

306901 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Chaetomiaceae › Chaetomium › Chaetomium globosum

Protein attributes

Sequence length	595 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 595	595	Probable Xaa-Pro aminopeptidase CHGG_02942		PRO_0000411831
Sites
	Metal binding	334	1	Manganese 2 By similarity
	Metal binding	345	1	Manganese 1 By similarity
	Metal binding	345	1	Manganese 2 By similarity
	Metal binding	541	1	Manganese 1 By similarity
	Metal binding	563	1	Manganese 1 By similarity
	Metal binding	563	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2HA12 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: A512A4CE40F6463E	FASTA	595	65,842
	10 20 30 40 50 60 MEFCDESYDL VNIDEFDALW VASRHGVAFG VPPCLLISDD DAIARSSIEL KSGPSSSNLS 70 80 90 100 110 120 PSTLSTEKTS SDSSGVICDP QLHETWREGL GKFPAKEHAR KVARELGADH GIIFLLGQDE 130 140 150 160 170 180 KYYEDSDMGP TFRQRRYFYY ITGADFPGCA VTYDILRDKL VLWIPRIEPR TVLWFGKVPT 190 200 210 220 230 240 PEECKAASDV DSVYYIDFLH EKQCPVFKRG QTIHVLHPDQ IPPELDHLGK FIRIDAVRLK 250 260 270 280 290 300 PAMDAARVIK TDYEIALIRR ANAVSSAAHK AVLRNIKRFT NEREIDALFR GYCIAHGAPI 310 320 330 340 350 360 QSYPVIAASG INASTLHYDD NNQSLKNRQL LILDAGAEVH CYASDITRTI PLPGSFTPLA 370 380 390 400 410 420 REIYRLVERM QDECIAQIKP GVRFSALHAH ACAVAVTGLL KLGILRGEEE EILARGTVAA 430 440 450 460 470 480 FFPHGLGHHV GLEVHDVSGT ERLLLNGGPG SGPGSGGGYG CGASTWRGYR LRRRVMTKRE 490 500 510 520 530 540 SLTPWEVAAL WEGAKPEKEK QQERWLLNNV PLDEVEAALT LASSSGARGQ KLAPGMVVTV 550 560 570 580 590 EPGIYFLPRV LEKYWNVGGV RIEDDILVTK KGYENLTTAP KGDEMMKCMG ESGLL

References

[1]

"Annotation of the Chaetomium globosum CBS 148.51 genome." The Broad Institute Genome Sequencing Platform Birren B.W., Lander E.S., Galagan J.E., Devon K., Nusbaum C., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K., Pushparaj V. , DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C.D., Yandava C., Zeng Q., Alvarado L., Oleary S., Untereiner W. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH408030 Genomic DNA. Translation: EAQ91007.1.
RefSeq	XP_001229458.1. XM_001229457.1.
3D structure databases
ProteinModelPortal	Q2HA12.
ModBase	Search...
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4389537.
Phylogenomic databases
OrthoDB	EOG4897VR.
Family and domain databases
Gene3D	3.90.230.10. 2 hits.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 2 hits.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_CHAGB

Accession

Primary (citable) accession number: Q2HA12

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	March 21, 2006
Last modified:	March 6, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program