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Q2H9G6

- CBPYA_CHAGB

UniProt

Q2H9G6 - CBPYA_CHAGB

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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei278 – 2781PROSITE-ProRule annotation
Active sitei470 – 4701PROSITE-ProRule annotation
Active sitei529 – 5291PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:CHGG_03138
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
ProteomesiUP000001056: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 137120By similarityPRO_0000407443Add
BLAST
Chaini138 – 554417Carboxypeptidase Y homolog APRO_0000407444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi191 ↔ 431By similarity
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi325 ↔ 339By similarity
Disulfide bondi349 ↔ 372By similarity
Disulfide bondi356 ↔ 365By similarity
Disulfide bondi394 ↔ 401By similarity
Glycosylationi518 – 5181N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ2H9G6.
SMRiQ2H9G6. Positions 137-549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiQ2H9G6.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2H9G6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIAASTVLF GAASAASFQQ QAQHVLSGGF GKAQEAMKPI SDAFTDAAGR
60 70 80 90 100
PFESFEDAFS GMTAETKALW EEIKLLVPDS AFKDLSWLSK PKPHHRRDDW
110 120 130 140 150
NHVVKGADVQ GMWVQDANGK SHRQVDGRLE EYNLRVKAVD PSKLNVDSVK
160 170 180 190 200
QYSGYLDDEA NDKHLFYWFF ESRNDPKNDP VILWLNGGPG CSSLTGLFLE
210 220 230 240 250
LGPSSIDKTL KVVNNDFSWN NNASVIFLDQ PVNVGYSYSG SSVSNTVAAG
260 270 280 290 300
KDVYALLTLF FHQFPEYAKQ DFHIAGESYA GHYIPVFASE ILAHKNRNIN
310 320 330 340 350
LKSVLIGNGL TDGLTQYEHY RPMACGEGGY PAVLGEAECR SMDNALPRCQ
360 370 380 390 400
SLINNCYESG SVWSCVPASI YCNNAMIGPY QRTGRNVYDI RGPCEDSSNL
410 420 430 440 450
CYSGLGYISD YLNQQSVMDA LGVEVSSYDS CNFDINRNFL FQGDWMQPFH
460 470 480 490 500
RLVPKILEEI PVLIYAGDAD YICNWLGNRA WTEALEWPGK KDFNAAKVKD
510 520 530 540 550
LKLSGAEKEY GKVKASGNFT FMQVYQAGHM VPMDQPENSL DFLNRWLNGE

WFAK
Length:554
Mass (Da):61,851
Last modified:March 21, 2006 - v1
Checksum:i7D613BD299241E48
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408030 Genomic DNA. Translation: EAQ91203.1.
RefSeqiXP_001229654.1. XM_001229653.1.

Genome annotation databases

GeneIDi4389770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408030 Genomic DNA. Translation: EAQ91203.1 .
RefSeqi XP_001229654.1. XM_001229653.1.

3D structure databases

ProteinModelPortali Q2H9G6.
SMRi Q2H9G6. Positions 137-549.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4389770.

Phylogenomic databases

InParanoidi Q2H9G6.
OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Entry informationi

Entry nameiCBPYA_CHAGB
AccessioniPrimary (citable) accession number: Q2H9G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 21, 2006
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3