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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei278PROSITE-ProRule annotation1
Active sitei470PROSITE-ProRule annotation1
Active sitei529PROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERichagb-q2h9g6. Carboxypeptidase_S10.
MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:CHGG_03138
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
Proteomesi
  • UP000001056 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040744318 – 137By similarityAdd BLAST120
ChainiPRO_0000407444138 – 554Carboxypeptidase Y homolog AAdd BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi191 ↔ 431By similarity
Glycosylationi222N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi325 ↔ 339By similarity
Disulfide bondi349 ↔ 372By similarity
Disulfide bondi356 ↔ 365By similarity
Disulfide bondi394 ↔ 401By similarity
Glycosylationi518N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi306901.XP_001229654.1.

Structurei

3D structure databases

ProteinModelPortaliQ2H9G6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
InParanoidiQ2H9G6.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR008442. Propeptide_carboxypepY.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2H9G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIAASTVLF GAASAASFQQ QAQHVLSGGF GKAQEAMKPI SDAFTDAAGR
60 70 80 90 100
PFESFEDAFS GMTAETKALW EEIKLLVPDS AFKDLSWLSK PKPHHRRDDW
110 120 130 140 150
NHVVKGADVQ GMWVQDANGK SHRQVDGRLE EYNLRVKAVD PSKLNVDSVK
160 170 180 190 200
QYSGYLDDEA NDKHLFYWFF ESRNDPKNDP VILWLNGGPG CSSLTGLFLE
210 220 230 240 250
LGPSSIDKTL KVVNNDFSWN NNASVIFLDQ PVNVGYSYSG SSVSNTVAAG
260 270 280 290 300
KDVYALLTLF FHQFPEYAKQ DFHIAGESYA GHYIPVFASE ILAHKNRNIN
310 320 330 340 350
LKSVLIGNGL TDGLTQYEHY RPMACGEGGY PAVLGEAECR SMDNALPRCQ
360 370 380 390 400
SLINNCYESG SVWSCVPASI YCNNAMIGPY QRTGRNVYDI RGPCEDSSNL
410 420 430 440 450
CYSGLGYISD YLNQQSVMDA LGVEVSSYDS CNFDINRNFL FQGDWMQPFH
460 470 480 490 500
RLVPKILEEI PVLIYAGDAD YICNWLGNRA WTEALEWPGK KDFNAAKVKD
510 520 530 540 550
LKLSGAEKEY GKVKASGNFT FMQVYQAGHM VPMDQPENSL DFLNRWLNGE

WFAK
Length:554
Mass (Da):61,851
Last modified:March 21, 2006 - v1
Checksum:i7D613BD299241E48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408030 Genomic DNA. Translation: EAQ91203.1.
RefSeqiXP_001229654.1. XM_001229653.1.

Genome annotation databases

EnsemblFungiiEAQ91203; EAQ91203; CHGG_03138.
GeneIDi4389770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408030 Genomic DNA. Translation: EAQ91203.1.
RefSeqiXP_001229654.1. XM_001229653.1.

3D structure databases

ProteinModelPortaliQ2H9G6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi306901.XP_001229654.1.

Protein family/group databases

ESTHERichagb-q2h9g6. Carboxypeptidase_S10.
MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAQ91203; EAQ91203; CHGG_03138.
GeneIDi4389770.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
InParanoidiQ2H9G6.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR008442. Propeptide_carboxypepY.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPYA_CHAGB
AccessioniPrimary (citable) accession number: Q2H9G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 21, 2006
Last modified: October 5, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.