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Q2H9G6

- CBPYA_CHAGB

UniProt

Q2H9G6 - CBPYA_CHAGB

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Protein

Carboxypeptidase Y homolog A

Gene
CPYA, CHGG_03138
Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei278 – 2781 By similarity
Active sitei470 – 4701 By similarity
Active sitei529 – 5291 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:CHGG_03138
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
ProteomesiUP000001056: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Propeptidei18 – 137120 By similarityPRO_0000407443Add
BLAST
Chaini138 – 554417Carboxypeptidase Y homolog APRO_0000407444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi191 ↔ 431 By similarity
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi325 ↔ 339 By similarity
Disulfide bondi349 ↔ 372 By similarity
Disulfide bondi356 ↔ 365 By similarity
Disulfide bondi394 ↔ 401 By similarity
Glycosylationi518 – 5181N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ2H9G6.
SMRiQ2H9G6. Positions 137-549.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2H9G6-1 [UniParc]FASTAAdd to Basket

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MRIAASTVLF GAASAASFQQ QAQHVLSGGF GKAQEAMKPI SDAFTDAAGR    50
PFESFEDAFS GMTAETKALW EEIKLLVPDS AFKDLSWLSK PKPHHRRDDW 100
NHVVKGADVQ GMWVQDANGK SHRQVDGRLE EYNLRVKAVD PSKLNVDSVK 150
QYSGYLDDEA NDKHLFYWFF ESRNDPKNDP VILWLNGGPG CSSLTGLFLE 200
LGPSSIDKTL KVVNNDFSWN NNASVIFLDQ PVNVGYSYSG SSVSNTVAAG 250
KDVYALLTLF FHQFPEYAKQ DFHIAGESYA GHYIPVFASE ILAHKNRNIN 300
LKSVLIGNGL TDGLTQYEHY RPMACGEGGY PAVLGEAECR SMDNALPRCQ 350
SLINNCYESG SVWSCVPASI YCNNAMIGPY QRTGRNVYDI RGPCEDSSNL 400
CYSGLGYISD YLNQQSVMDA LGVEVSSYDS CNFDINRNFL FQGDWMQPFH 450
RLVPKILEEI PVLIYAGDAD YICNWLGNRA WTEALEWPGK KDFNAAKVKD 500
LKLSGAEKEY GKVKASGNFT FMQVYQAGHM VPMDQPENSL DFLNRWLNGE 550
WFAK 554
Length:554
Mass (Da):61,851
Last modified:March 21, 2006 - v1
Checksum:i7D613BD299241E48
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408030 Genomic DNA. Translation: EAQ91203.1.
RefSeqiXP_001229654.1. XM_001229653.1.

Genome annotation databases

GeneIDi4389770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408030 Genomic DNA. Translation: EAQ91203.1 .
RefSeqi XP_001229654.1. XM_001229653.1.

3D structure databases

ProteinModelPortali Q2H9G6.
SMRi Q2H9G6. Positions 137-549.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4389770.

Phylogenomic databases

OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Entry informationi

Entry nameiCBPYA_CHAGB
AccessioniPrimary (citable) accession number: Q2H9G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 21, 2006
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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