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Protein

Catalase-peroxidase

Gene

katG

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei87 – 871Transition state stabilizerUniRule annotation
Active sitei91 – 911Proton acceptorUniRule annotation
Metal bindingi279 – 2791Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3408. CgCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
ORF Names:CHGG_05274
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
Proteomesi
  • UP000001056 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Catalase-peroxidasePRO_0000354105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki90 ↔ 238Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-264)UniRule annotation
Cross-linki238 ↔ 264Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-90)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi306901.XP_001221369.1.

Structurei

3D structure databases

ProteinModelPortaliQ2H7U1.
SMRiQ2H7U1. Positions 15-740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IEWS. Eukaryota.
COG0376. LUCA.
InParanoidiQ2H7U1.
OrthoDBiEOG7BKD32.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2H7U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGECPVNHAN VAGGGTRNND WWPNQLRLNI LRQHQPASSP YSKEFDYAAA
60 70 80 90 100
FKSLDYEALK KDITAVMTDS QDWWPADFGH YGGLFIRMAW HSAGTYRVFD
110 120 130 140 150
GRGGGSQGQQ RFAPLNSWPD NVSLDKARRL LWPVKQKYGD KISWADLLLL
160 170 180 190 200
TGNVALESMG FKTFGFAGGR PDTWEADESA YWGGEKTWLG NDVRYGQGNE
210 220 230 240 250
GVAGQGVVDG DESKKGHRDI HSRDLESPLA AAHMGLIYVN PEGPDGIPDP
260 270 280 290 300
VAAGRDIRTT FGRMAMNDEE TVALIAGGHT FGKTHGAAPA VNVSKEPEAA
310 320 330 340 350
PLEQQGLGWS NKHGTGKGPD TITSGLEVIW TKEPTKWTHN FFEYLFKFEW
360 370 380 390 400
ELTKSPAGAN QWVAKNTEPI IPDAFDPNKK HLPRMLTTDL ALRFDPEYEK
410 420 430 440 450
ISRRFLENPD QFADAFARAW FKLLHRDLGP RSRWLGPEIP SEVLIWEDPV
460 470 480 490 500
PAVNHPLVDE QDVTTLKRAI LATGVAPAKL ISTAWASAST FRGGDKRGGA
510 520 530 540 550
NGARIRLAPQ KDWKVNNPPQ LAEVLKALEG VQAQFNGASQ SKKVSLADLI
560 570 580 590 600
VLGGVAALEQ AAGVSVPFTP GRTDASQEQT EVESFAHLEP HVDGFRSYGR
610 620 630 640 650
GTSRVSTEQF LVDRAHLLTL TPPELAVLVG GLRVLGANYD GSSNGVFTTR
660 670 680 690 700
PGKLTNDYFV NLLDMATAWK SVDGEVFEGN DRKTGEKKWT GTRADLVFGA
710 720 730 740
HAELRAISEV YGSSSGQDKF VKDFVAAWSK VMNLDRYDLA QPGSSGPKL
Length:749
Mass (Da):82,096
Last modified:March 21, 2006 - v1
Checksum:iED0BA56EA1FB6617
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408031 Genomic DNA. Translation: EAQ88655.1.
RefSeqiXP_001221369.1. XM_001221368.1.

Genome annotation databases

EnsemblFungiiEAQ88655; EAQ88655; CHGG_05274.
GeneIDi4391274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408031 Genomic DNA. Translation: EAQ88655.1.
RefSeqiXP_001221369.1. XM_001221368.1.

3D structure databases

ProteinModelPortaliQ2H7U1.
SMRiQ2H7U1. Positions 15-740.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi306901.XP_001221369.1.

Protein family/group databases

PeroxiBasei3408. CgCP01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAQ88655; EAQ88655; CHGG_05274.
GeneIDi4391274.

Phylogenomic databases

eggNOGiENOG410IEWS. Eukaryota.
COG0376. LUCA.
InParanoidiQ2H7U1.
OrthoDBiEOG7BKD32.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Draft genome sequence of the cellulolytic fungus Chaetomium globosum."
    Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.
    Genome Announc. 3:E0002115-E0002115(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Entry informationi

Entry nameiKATG_CHAGB
AccessioniPrimary (citable) accession number: Q2H7U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: March 21, 2006
Last modified: July 6, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.